| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Consonance Capital Management LP | 3,460,323 | 66,750,000 | 8.52% | ||
| 2 | Broadfin Capital, LLC | 2,959,790 | 57,094,000 | 7.29% | ||
| 3 | PERCEPTIVE ADVISORS LLC | 2,579,380 | 49,756,000 | 6.35% | ||
| 4 | JENNISON ASSOCIATES LLC | 2,343,659 | 45,209,000 | 5.77% | ||
| 5 | FRANKLIN RESOURCES INC | 1,514,450 | 29,214,000 | 3.73% | ||
| 6 | GOLDMAN SACHS GROUP INC | 1,451,100 | 27,992,000 | 3.57% | Call | |
| 7 | BlackRock Fund Advisors | 1,280,086 | 24,693,000 | 3.15% | ||
| 8 | FMR LLC | 1,255,418 | 24,217,000 | 3.09% | ||
| 9 | GOLDMAN SACHS GROUP INC | 1,242,000 | 23,958,000 | 3.06% | Put | |
| 10 | STATE STREET CORP | 1,233,607 | 23,794,000 | 3.04% | ||
| 11 | EcoR1 Capital, LLC | 1,224,384 | 23,618,000 | 3.02% | ||
| 12 | VANGUARD GROUP INC | 1,170,451 | 22,578,000 | 2.88% | ||
| 13 | Lombard Odier Asset Management (USA) Corp | 1,144,720 | 22,082,000 | 2.82% | ||
| 14 | SENZAR ASSET MANAGEMENT, LLC | 1,058,882 | 20,425,834 | 2.61% | ||
| 15 | JENNISON ASSOCIATES LLC | 1,000,000 | 19,290,000 | 2.46% | Call | |
| 16 | Amici Capital, LLC | 942,130 | 18,174,000 | 2.32% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 828,680 | 15,985,000 | 2.04% | ||
| 18 | Invesco Ltd. | 756,398 | 14,591,000 | 1.86% | ||
| 19 | PRICE T ROWE ASSOCIATES INC /MD/ | 718,089 | 13,852,000 | 1.77% | ||
| 20 | Rock Springs Capital Management LP | 675,000 | 13,021,000 | 1.66% | ||
| 21 | DEUTSCHE BANK AG\ | 662,957 | 12,786,000 | 1.63% | ||
| 22 | BARCLAYS PLC | 590,900 | 11,227,000 | 1.43% | Put | |
| 23 | GOLDMAN SACHS GROUP INC | 520,182 | 10,034,000 | 1.28% | ||
| 24 | Bank of New York Mellon Corp | 506,143 | 9,763,000 | 1.25% | ||
| 25 | MILLENNIUM MANAGEMENT LLC | 483,299 | 9,323,000 | 1.19% | ||
| 26 | MACQUARIE GROUP LTD | 454,203 | 8,762,000 | 1.12% | ||
| 27 | TAMRO Capital Partners LLC | 440,868 | 8,504,000 | 1.09% | ||
| 28 | NORTHERN TRUST CORP | 395,914 | 7,637,000 | 0.98% | ||
| 29 | TURNER INVESTMENTS LLC | 384,760 | 7,422,000 | 0.95% | ||
| 30 | ACUTA CAPITAL PARTNERS, LLC | 370,000 | 7,137,000 | 0.91% | ||
| 31 | SCOPIA CAPITAL MANAGEMENT LP | 369,135 | 7,121,000 | 0.91% | ||
| 32 | Park West Asset Management LLC | 350,000 | 6,752,000 | 0.86% | ||
| 33 | Opaleye Management Inc. | 345,000 | 6,655,000 | 0.85% | ||
| 34 | Tekla Capital Management LLC | 329,949 | 6,365,000 | 0.81% | ||
| 35 | BNP Paribas Asset Management Holding S.A. | 328,294 | 6,333,000 | 0.81% | ||
| 36 | BARCLAYS PLC | 310,933 | 5,908,000 | 0.75% | ||
| 37 | OXFORD ASSET MANAGEMENT LLP | 243,448 | 4,746,000 | 0.61% | ||
| 38 | Spark Investment Management LLC | 239,500 | 4,619,000 | 0.59% | ||
| 39 | GEODE CAPITAL MANAGEMENT, LLC | 239,454 | 4,619,000 | 0.59% | ||
| 40 | TEACHERS ADVISORS, LLC | 202,536 | 3,907,000 | 0.50% | ||
| 41 | Ghost Tree Capital, LLC | 200,000 | 3,858,000 | 0.49% | ||
| 42 | WALL STREET ASSOCIATES | 198,695 | 3,833,000 | 0.49% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 187,300 | 3,613,000 | 0.46% | Call | |
| 44 | Telemetry Investments, L.L.C. | 180,000 | 3,472,000 | 0.44% | ||
| 45 | WADDELL & REED FINANCIAL INC | 154,971 | 2,989,000 | 0.38% | ||
| 46 | BARCLAYS PLC | 155,800 | 2,960,000 | 0.38% | Call | |
| 47 | CITADEL ADVISORS LLC | 149,915 | 2,892,000 | 0.37% | ||
| 48 | Connor, Clark & Lunn Investment Management Ltd. | 149,050 | 2,875,000 | 0.37% | ||
| 49 | SPHERA FUNDS MANAGEMENT LTD. | 135,000 | 2,604,000 | 0.33% | ||
| 50 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 126,860 | 2,448,000 | 0.31% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
