| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | QVT Financial LP | 2,287,583 | 47,908,000 | 16.75% | ||
| 2 | JENNISON ASSOCIATES LLC | 1,969,819 | 41,898,000 | 14.65% | ||
| 3 | Broadfin Capital, LLC | 1,609,696 | 34,126,000 | 11.93% | ||
| 4 | PUTNAM INVESTMENTS LLC | 1,413,562 | 30,066,000 | 10.51% | ||
| 5 | Opaleye Management Inc. | 1,153,230 | 24,448,000 | 8.55% | ||
| 6 | PERCEPTIVE ADVISORS LLC | 1,044,292 | 22,138,000 | 7.74% | ||
| 7 | BlackRock Fund Advisors | 527,333 | 11,179,000 | 3.91% | ||
| 8 | Lombard Odier Asset Management (USA) Corp | 450,000 | 9,540,000 | 3.34% | ||
| 9 | DEUTSCHE BANK AG\ | 369,676 | 7,836,000 | 2.74% | ||
| 10 | Visium Asset Management, LP | 305,500 | 6,498,000 | 2.27% | ||
| 11 | SIGMA CAPITAL MANAGEMENT LLC | 305,000 | 6,487,000 | 2.27% | ||
| 12 | VANGUARD GROUP INC | 275,082 | 5,851,000 | 2.05% | ||
| 13 | ASCEND CAPITAL, LLC | 264,801 | 5,613,000 | 1.96% | ||
| 14 | BAKER BROS. ADVISORS LP | 197,178 | 4,194,000 | 1.47% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 184,166 | 3,904,000 | 1.37% | ||
| 16 | STATE STREET CORP | 182,276 | 3,876,000 | 1.36% | ||
| 17 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 130,917 | 2,775,000 | 0.97% | ||
| 18 | JANE STREET GROUP, LLC | 119,356 | 2,531,000 | 0.89% | ||
| 19 | Catalyst Capital Advisors LLC | 84,500 | 1,797,000 | 0.63% | ||
| 20 | TIAA CREF INVESTMENT MANAGEMENT LLC | 71,017 | 1,511,000 | 0.53% | ||
| 21 | CREDIT SUISSE AG/ | 57,457 | 1,218,000 | 0.43% | ||
| 22 | BlackRock Investment Management, LLC | 54,252 | 1,150,000 | 0.40% | ||
| 23 | Bank of New York Mellon Corp | 51,790 | 1,098,000 | 0.38% | ||
| 24 | NORTHERN TRUST CORP | 43,915 | 931,000 | 0.33% | ||
| 25 | ClariVest Asset Management LLC | 39,297 | 837,000 | 0.29% | ||
| 26 | UBS AG | 37,966 | 805,000 | 0.28% | ||
| 27 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 34,600 | 736,000 | 0.26% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 30,664 | 652,000 | 0.23% | ||
| 29 | TEACHERS ADVISORS, LLC | 27,450 | 584,000 | 0.20% | ||
| 30 | CITADEL ADVISORS LLC | 26,718 | 568,000 | 0.20% | ||
| 31 | MILLENNIUM MANAGEMENT LLC | 25,700 | 545,000 | 0.19% | ||
| 32 | METROPOLITAN LIFE INSURANCE CO/NY | 20,202 | 430,000 | 0.15% | ||
| 33 | TIEDEMANN TRUST CO | 19,593 | 415,000 | 0.15% | ||
| 34 | RUSSELL FRANK CO/ | 24,200 | 341,000 | 0.12% | ||
| 35 | BlackRock Group LTD | 15,502 | 329,000 | 0.12% | ||
| 36 | D. E. Shaw & Co., Inc. | 10,135 | 216,000 | 0.08% | ||
| 37 | BLACKROCK ADVISORS LLC | 9,812 | 208,000 | 0.07% | ||
| 38 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 7,500 | 159,000 | 0.06% | ||
| 39 | BANK OF MONTREAL /CAN/ | 5,933 | 126,000 | 0.04% | ||
| 40 | Nationwide Fund Advisors | 5,831 | 124,000 | 0.04% | ||
| 41 | Tower Research Capital LLC (TRC) | 5,186 | 110,000 | 0.04% | ||
| 42 | SAC Capital Advisors LP | 3,932 | 84,000 | 0.03% | ||
| 43 | CITIGROUP INC | 1,999 | 43,000 | 0.02% | ||
| 44 | ALLIANCEBERNSTEIN L.P. | 1,810 | 38,000 | 0.01% | ||
| 45 | TradeLink Global Equity LLC | 900 | 19,000 | 0.01% | ||
| 46 | BlackRock Finance, Inc. | 524 | 11,000 | 0.00% | ||
| 47 | Stevens First Principles Investment Advisors | 500 | 11,000 | 0.00% | ||
| 48 | BARCLAYS PLC | 519 | 11,000 | 0.00% | ||
| 49 | CENTRAL TRUST Co | 300 | 6,000 | 0.00% | ||
| 50 | MORGAN STANLEY | 90 | 2,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
