| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JENNISON ASSOCIATES LLC | 3,243,887 | 77,724,000 | 9.74% | ||
| 2 | Consonance Capital Management LP | 3,107,710 | 74,461,000 | 9.33% | ||
| 3 | Broadfin Capital, LLC | 2,962,298 | 70,977,000 | 8.89% | ||
| 4 | PERCEPTIVE ADVISORS LLC | 2,784,980 | 66,728,000 | 8.36% | ||
| 5 | Lombard Odier Asset Management (USA) Corp | 2,002,933 | 47,990,000 | 6.01% | ||
| 6 | Amici Capital, LLC | 1,250,700 | 29,967,000 | 3.75% | ||
| 7 | FRANKLIN RESOURCES INC | 1,210,450 | 29,002,000 | 3.63% | ||
| 8 | BlackRock Fund Advisors | 1,091,984 | 26,164,000 | 3.28% | ||
| 9 | GOLDMAN SACHS GROUP INC | 1,068,300 | 25,596,000 | 3.21% | Call | |
| 10 | PUTNAM INVESTMENTS LLC | 1,043,352 | 24,998,000 | 3.13% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 940,402 | 22,532,000 | 2.82% | ||
| 12 | PRICE T ROWE ASSOCIATES INC /MD/ | 747,200 | 17,903,000 | 2.24% | ||
| 13 | VANGUARD GROUP INC | 721,133 | 17,279,000 | 2.16% | ||
| 14 | Rock Springs Capital Management LP | 700,000 | 16,772,000 | 2.10% | ||
| 15 | FMR LLC | 698,400 | 16,734,000 | 2.10% | ||
| 16 | DEUTSCHE BANK AG\ | 677,984 | 16,242,000 | 2.03% | ||
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 596,600 | 14,295,000 | 1.79% | Call | |
| 18 | WALL STREET ASSOCIATES | 560,695 | 13,434,000 | 1.68% | ||
| 19 | BlackRock Institutional Trust Company, N.A. | 507,866 | 12,168,000 | 1.52% | ||
| 20 | Opaleye Management Inc. | 500,000 | 11,980,000 | 1.50% | ||
| 21 | Park West Asset Management LLC | 487,144 | 11,672,000 | 1.46% | ||
| 22 | GOLDMAN SACHS GROUP INC | 487,062 | 11,670,000 | 1.46% | ||
| 23 | SENZAR ASSET MANAGEMENT, LLC | 478,900 | 11,474,000 | 1.44% | ||
| 24 | Broadfin Capital, LLC | 500,000 | 11,198,000 | 1.40% | Call | |
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 440,700 | 10,559,000 | 1.32% | Put | |
| 26 | Laurion Capital Management LP | 420,677 | 10,079,000 | 1.26% | ||
| 27 | EcoR1 Capital, LLC | 410,000 | 9,824,000 | 1.23% | ||
| 28 | STATE STREET CORP | 387,488 | 9,284,000 | 1.16% | ||
| 29 | QVT Financial LP | 308,989 | 7,403,000 | 0.93% | ||
| 30 | NORTHERN TRUST CORP | 229,057 | 5,489,000 | 0.69% | ||
| 31 | Connor, Clark & Lunn Investment Management Ltd. | 182,900 | 4,382,000 | 0.55% | ||
| 32 | TURNER INVESTMENTS LLC | 169,980 | 4,073,000 | 0.51% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 166,801 | 3,996,000 | 0.50% | ||
| 34 | DEERFIELD MANAGEMENT COMPANY, L.P. | 158,223 | 3,791,000 | 0.47% | ||
| 35 | NEXT CENTURY GROWTH INVESTORS LLC | 154,706 | 3,706,000 | 0.46% | ||
| 36 | AQR ARBITRAGE LLC | 149,500 | 3,582,000 | 0.45% | ||
| 37 | Visium Asset Management, LP | 137,696 | 3,299,000 | 0.41% | ||
| 38 | Alyeska Investment Group, L.P. | 125,000 | 2,995,000 | 0.38% | ||
| 39 | Bank of New York Mellon Corp | 123,343 | 2,955,000 | 0.37% | ||
| 40 | SPHERA FUNDS MANAGEMENT LTD. | 111,392 | 2,669,000 | 0.33% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 99,376 | 2,381,000 | 0.30% | ||
| 42 | BlackRock Investment Management, LLC | 79,825 | 1,913,000 | 0.24% | ||
| 43 | Telemetry Investments, L.L.C. | 79,600 | 1,907,000 | 0.24% | ||
| 44 | Invesco Ltd. | 69,716 | 1,670,000 | 0.21% | ||
| 45 | CREDIT SUISSE AG/ | 69,409 | 1,663,000 | 0.21% | ||
| 46 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 67,900 | 1,627,000 | 0.20% | ||
| 47 | Round Table Services, LLC | 60,000 | 1,438,000 | 0.18% | ||
| 48 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 54,824 | 1,314,000 | 0.16% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 50,091 | 1,200,000 | 0.15% | ||
| 50 | MONASHEE INVESTMENT MANAGEMENT LLC | 50,000 | 1,198,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
