| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Consonance Capital Management LP | 3,450,323 | 69,904,000 | 8.48% | ||
| 2 | PERCEPTIVE ADVISORS LLC | 2,647,080 | 53,629,000 | 6.50% | ||
| 3 | Broadfin Capital, LLC | 2,609,790 | 52,874,000 | 6.41% | ||
| 4 | JENNISON ASSOCIATES LLC | 2,277,360 | 46,139,000 | 5.59% | ||
| 5 | GOLDMAN SACHS GROUP INC | 1,948,200 | 39,471,000 | 4.79% | Call | |
| 6 | FRANKLIN RESOURCES INC | 1,557,150 | 31,548,000 | 3.83% | ||
| 7 | GOLDMAN SACHS GROUP INC | 1,460,200 | 29,584,000 | 3.59% | Put | |
| 8 | STATE STREET CORP | 1,398,986 | 28,342,000 | 3.44% | ||
| 9 | BlackRock Fund Advisors | 1,343,272 | 27,215,000 | 3.30% | ||
| 10 | Lombard Odier Asset Management (USA) Corp | 1,236,705 | 25,056,000 | 3.04% | ||
| 11 | VANGUARD GROUP INC | 1,151,299 | 23,325,000 | 2.83% | ||
| 12 | Amici Capital, LLC | 1,085,515 | 21,993,000 | 2.67% | ||
| 13 | EcoR1 Capital, LLC | 1,007,660 | 20,415,000 | 2.48% | ||
| 14 | JENNISON ASSOCIATES LLC | 1,000,000 | 20,260,000 | 2.46% | Call | |
| 15 | BlackRock Institutional Trust Company, N.A. | 759,305 | 15,384,000 | 1.87% | ||
| 16 | Invesco Ltd. | 724,404 | 14,676,000 | 1.78% | ||
| 17 | SENZAR ASSET MANAGEMENT, LLC | 722,100 | 14,629,746 | 1.77% | ||
| 18 | PRICE T ROWE ASSOCIATES INC /MD/ | 720,089 | 14,589,000 | 1.77% | ||
| 19 | Rock Springs Capital Management LP | 683,900 | 13,856,000 | 1.68% | ||
| 20 | DEUTSCHE BANK AG\ | 672,239 | 13,618,000 | 1.65% | ||
| 21 | TAMRO Capital Partners LLC | 651,228 | 13,194,000 | 1.60% | ||
| 22 | FMR LLC | 607,900 | 12,316,000 | 1.49% | ||
| 23 | PUTNAM INVESTMENTS LLC | 535,328 | 10,845,000 | 1.31% | ||
| 24 | GOLDMAN SACHS GROUP INC | 503,052 | 10,192,000 | 1.24% | ||
| 25 | Broadfin Capital, LLC | 500,000 | 10,130,000 | 1.23% | Call | |
| 26 | MILLENNIUM MANAGEMENT LLC | 462,134 | 9,363,000 | 1.14% | ||
| 27 | Bank of New York Mellon Corp | 424,873 | 8,607,000 | 1.04% | ||
| 28 | NORTHERN TRUST CORP | 373,441 | 7,566,000 | 0.92% | ||
| 29 | Opaleye Management Inc. | 370,000 | 7,496,000 | 0.91% | ||
| 30 | WELLS FARGO & COMPANY/MN | 344,169 | 6,972,000 | 0.85% | ||
| 31 | WALL STREET ASSOCIATES | 313,695 | 6,355,000 | 0.77% | ||
| 32 | BNP Paribas Asset Management Holding S.A. | 305,113 | 6,182,000 | 0.75% | ||
| 33 | QVT Financial LP | 296,570 | 6,009,000 | 0.73% | ||
| 34 | MACQUARIE GROUP LTD | 295,843 | 5,994,000 | 0.73% | ||
| 35 | Park West Asset Management LLC | 289,678 | 5,869,000 | 0.71% | ||
| 36 | TWO SIGMA INVESTMENTS, LP | 286,978 | 5,814,000 | 0.70% | ||
| 37 | MORGAN STANLEY | 270,535 | 5,481,000 | 0.66% | ||
| 38 | EVENTIDE ASSET MANAGEMENT, LLC | 240,600 | 4,875,000 | 0.59% | ||
| 39 | TURNER INVESTMENTS LLC | 238,040 | 4,823,000 | 0.58% | ||
| 40 | GEODE CAPITAL MANAGEMENT, LLC | 224,681 | 4,552,000 | 0.55% | ||
| 41 | TWO SIGMA ADVISERS, LP | 196,607 | 4,147,000 | 0.50% | ||
| 42 | WADDELL & REED FINANCIAL INC | 196,300 | 3,977,000 | 0.48% | ||
| 43 | Point72 Asset Management, L.P. | 194,000 | 3,930,000 | 0.48% | ||
| 44 | Spark Investment Management LLC | 193,400 | 3,914,000 | 0.47% | ||
| 45 | CASTLEARK MANAGEMENT LLC | 178,034 | 3,607,000 | 0.44% | ||
| 46 | EverPoint Asset Management, LLC | 175,000 | 3,546,000 | 0.43% | ||
| 47 | TEACHERS ADVISORS, LLC | 172,136 | 3,487,000 | 0.42% | ||
| 48 | SPHERA FUNDS MANAGEMENT LTD. | 150,000 | 3,039,000 | 0.37% | ||
| 49 | Telemetry Investments, L.L.C. | 148,000 | 2,998,000 | 0.36% | ||
| 50 | Connor, Clark & Lunn Investment Management Ltd. | 145,150 | 2,941,000 | 0.36% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
