| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | SCOPIA CAPITAL MANAGEMENT LP | 4,252,888 | 95,180,000 | 10.54% | ||
| 2 | Broadfin Capital, LLC | 3,469,271 | 77,642,000 | 8.60% | ||
| 3 | Consonance Capital Management LP | 3,084,947 | 69,041,000 | 7.65% | ||
| 4 | PERCEPTIVE ADVISORS LLC | 2,446,482 | 54,752,000 | 6.06% | ||
| 5 | JENNISON ASSOCIATES LLC | 2,123,487 | 47,524,000 | 5.26% | ||
| 6 | FMR LLC | 1,773,461 | 39,690,000 | 4.39% | ||
| 7 | BlackRock Fund Advisors | 1,415,218 | 31,673,000 | 3.51% | ||
| 8 | VANGUARD GROUP INC | 1,332,483 | 29,820,000 | 3.30% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 1,195,978 | 26,766,000 | 2.96% | ||
| 10 | Invesco Ltd. | 1,129,864 | 25,286,000 | 2.80% | ||
| 11 | FRANKLIN RESOURCES INC | 1,104,150 | 24,711,000 | 2.74% | ||
| 12 | STATE STREET CORP | 1,050,175 | 23,503,000 | 2.60% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 949,055 | 21,240,000 | 2.35% | ||
| 14 | PRICE T ROWE ASSOCIATES INC /MD/ | 848,870 | 18,998,000 | 2.10% | ||
| 15 | Lombard Odier Asset Management (USA) Corp | 844,474 | 18,899,000 | 2.09% | ||
| 16 | MACQUARIE GROUP LTD | 817,732 | 18,301,000 | 2.03% | ||
| 17 | DEUTSCHE BANK AG\ | 623,329 | 13,949,000 | 1.54% | ||
| 18 | EverPoint Asset Management, LLC | 600,000 | 13,428,000 | 1.49% | ||
| 19 | GOLDMAN SACHS GROUP INC | 540,238 | 12,090,000 | 1.34% | ||
| 20 | Rock Springs Capital Management LP | 522,000 | 11,682,000 | 1.29% | ||
| 21 | SENZAR ASSET MANAGEMENT, LLC | 470,789 | 10,536,258 | 1.17% | ||
| 22 | Bank of New York Mellon Corp | 414,507 | 9,276,000 | 1.03% | ||
| 23 | MORGAN STANLEY | 402,216 | 9,002,000 | 1.00% | ||
| 24 | NORTHERN TRUST CORP | 388,278 | 8,689,000 | 0.96% | ||
| 25 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 380,075 | 8,506,000 | 0.94% | ||
| 26 | Amici Capital, LLC | 330,030 | 7,386,000 | 0.82% | ||
| 27 | Tekla Capital Management LLC | 329,949 | 7,384,000 | 0.82% | ||
| 28 | TWO SIGMA INVESTMENTS, LP | 301,230 | 6,742,000 | 0.75% | ||
| 29 | GOLDMAN SACHS GROUP INC | 290,300 | 6,497,000 | 0.72% | Call | |
| 30 | DIMENSIONAL FUND ADVISORS LP | 285,049 | 6,379,000 | 0.71% | ||
| 31 | TEACHERS ADVISORS, LLC | 276,874 | 6,196,000 | 0.69% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 275,794 | 6,172,000 | 0.68% | ||
| 33 | Ghost Tree Capital, LLC | 250,000 | 5,595,000 | 0.62% | ||
| 34 | Numeric Investors LLC | 245,800 | 5,501,000 | 0.61% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 245,300 | 5,490,000 | 0.61% | Call | |
| 36 | MILLENNIUM MANAGEMENT LLC | 243,500 | 5,450,000 | 0.60% | Call | |
| 37 | Spark Investment Management LLC | 228,700 | 5,118,000 | 0.57% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 220,250 | 4,929,000 | 0.55% | ||
| 39 | BOSTON ADVISORS LLC | 218,325 | 4,886,000 | 0.54% | ||
| 40 | Signpost Capital Advisors, LP | 203,141 | 4,546,000 | 0.50% | ||
| 41 | WALL STREET ASSOCIATES | 198,695 | 4,447,000 | 0.49% | ||
| 42 | SPHERA FUNDS MANAGEMENT LTD. | 190,000 | 4,252,000 | 0.47% | ||
| 43 | AJO, LP | 167,524 | 3,749,000 | 0.42% | ||
| 44 | GW&K Investment Management, LLC | 160,861 | 3,600,000 | 0.40% | ||
| 45 | OXFORD ASSET MANAGEMENT LLP | 160,675 | 3,596,000 | 0.40% | ||
| 46 | Point72 Asset Management, L.P. | 150,800 | 3,375,000 | 0.37% | ||
| 47 | MAVERICK CAPITAL LTD | 148,661 | 3,327,000 | 0.37% | ||
| 48 | BlackRock Investment Management, LLC | 147,254 | 3,296,000 | 0.36% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 132,108 | 2,957,000 | 0.33% | ||
| 50 | AQR CAPITAL MANAGEMENT LLC | 120,453 | 2,696,000 | 0.30% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
