| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | SCOPIA CAPITAL MANAGEMENT LP | 3,811,821 | 67,889,000 | 9.29% | ||
| 2 | PERCEPTIVE ADVISORS LLC | 3,279,380 | 58,405,000 | 7.99% | ||
| 3 | Consonance Capital Management LP | 2,699,947 | 48,086,000 | 6.58% | ||
| 4 | Broadfin Capital, LLC | 2,662,591 | 47,421,000 | 6.49% | ||
| 5 | JENNISON ASSOCIATES LLC | 2,264,275 | 40,327,000 | 5.52% | ||
| 6 | FMR LLC | 1,997,470 | 35,575,000 | 4.87% | ||
| 7 | BlackRock Fund Advisors | 1,325,946 | 23,615,000 | 3.23% | ||
| 8 | VANGUARD GROUP INC | 1,255,576 | 22,362,000 | 3.06% | ||
| 9 | EcoR1 Capital, LLC | 1,225,084 | 21,819,000 | 2.99% | ||
| 10 | Invesco Ltd. | 1,170,083 | 20,840,000 | 2.85% | ||
| 11 | FRANKLIN RESOURCES INC | 1,104,150 | 19,665,000 | 2.69% | ||
| 12 | Lombard Odier Asset Management (USA) Corp | 1,082,572 | 19,281,000 | 2.64% | ||
| 13 | GOLDMAN SACHS GROUP INC | 990,500 | 17,641,000 | 2.41% | Put | |
| 14 | STATE STREET CORP | 975,423 | 17,372,000 | 2.38% | ||
| 15 | MACQUARIE GROUP LTD | 929,316 | 16,551,000 | 2.26% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 905,395 | 16,125,000 | 2.21% | ||
| 17 | DEUTSCHE BANK AG\ | 882,077 | 15,708,000 | 2.15% | ||
| 18 | GOLDMAN SACHS GROUP INC | 864,000 | 15,388,000 | 2.11% | ||
| 19 | Park West Asset Management LLC | 800,000 | 14,248,000 | 1.95% | ||
| 20 | MILLENNIUM MANAGEMENT LLC | 776,294 | 13,826,000 | 1.89% | ||
| 21 | PRICE T ROWE ASSOCIATES INC /MD/ | 708,689 | 12,622,000 | 1.73% | ||
| 22 | Amici Capital, LLC | 638,030 | 11,363,000 | 1.55% | ||
| 23 | CITADEL ADVISORS LLC | 582,825 | 10,380,000 | 1.42% | ||
| 24 | EverPoint Asset Management, LLC | 550,000 | 9,796,000 | 1.34% | ||
| 25 | Bank of New York Mellon Corp | 522,706 | 9,310,000 | 1.27% | ||
| 26 | Rock Springs Capital Management LP | 521,400 | 9,286,000 | 1.27% | ||
| 27 | NORTHERN TRUST CORP | 379,439 | 6,758,000 | 0.92% | ||
| 28 | Tekla Capital Management LLC | 329,949 | 5,876,000 | 0.80% | ||
| 29 | SENZAR ASSET MANAGEMENT, LLC | 329,489 | 5,868,199 | 0.80% | ||
| 30 | Spark Investment Management LLC | 305,300 | 5,437,000 | 0.74% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 274,100 | 4,882,000 | 0.67% | Call | |
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 270,805 | 4,823,000 | 0.66% | ||
| 33 | TEACHERS ADVISORS, LLC | 234,444 | 4,175,000 | 0.57% | ||
| 34 | OXFORD ASSET MANAGEMENT LLP | 216,084 | 3,848,000 | 0.53% | ||
| 35 | WALL STREET ASSOCIATES | 198,695 | 3,539,000 | 0.48% | ||
| 36 | UBS Group AG | 180,000 | 3,206,000 | 0.44% | Put | |
| 37 | Point72 Asset Management, L.P. | 174,800 | 3,113,000 | 0.43% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 166,900 | 2,972,000 | 0.41% | Put | |
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 160,757 | 2,863,000 | 0.39% | ||
| 40 | SPHERA FUNDS MANAGEMENT LTD. | 150,000 | 2,672,000 | 0.37% | ||
| 41 | BlackRock Investment Management, LLC | 147,822 | 2,633,000 | 0.36% | ||
| 42 | EMERALD ACQUISITION LTD. | 130,936 | 2,332,000 | 0.32% | ||
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 120,921 | 2,154,000 | 0.29% | ||
| 44 | Lombard Odier Asset Management (USA) Corp | 100,000 | 1,781,000 | 0.24% | Call | |
| 45 | ACUTA CAPITAL PARTNERS, LLC | 98,788 | 1,759,000 | 0.24% | ||
| 46 | J. Goldman & Co LP | 98,500 | 1,754,000 | 0.24% | ||
| 47 | Jefferies Group LLC | 97,300 | 1,733,000 | 0.24% | Call | |
| 48 | GW&K Investment Management, LLC | 95,987 | 1,710,000 | 0.23% | ||
| 49 | TURNER INVESTMENTS LLC | 90,354 | 1,609,000 | 0.22% | ||
| 50 | MARSHALL WACE, LLP | 90,194 | 1,606,000 | 0.22% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
