| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Consonance Capital Management LP | 3,400,323 | 112,721,000 | 9.86% | ||
| 2 | JENNISON ASSOCIATES LLC | 2,967,503 | 98,373,000 | 8.61% | ||
| 3 | PERCEPTIVE ADVISORS LLC | 2,820,875 | 91,650,000 | 8.02% | ||
| 4 | Broadfin Capital, LLC | 2,162,928 | 71,701,000 | 6.27% | ||
| 5 | FRANKLIN RESOURCES INC | 1,468,250 | 48,672,000 | 4.26% | ||
| 6 | Lombard Odier Asset Management (USA) Corp | 1,381,949 | 45,812,000 | 4.01% | ||
| 7 | STATE STREET CORP | 1,316,705 | 43,650,000 | 3.82% | ||
| 8 | BlackRock Fund Advisors | 1,287,202 | 42,671,000 | 3.73% | ||
| 9 | Amici Capital, LLC | 1,132,700 | 37,549,000 | 3.28% | ||
| 10 | VANGUARD GROUP INC | 1,037,597 | 34,396,000 | 3.01% | ||
| 11 | GOLDMAN SACHS GROUP INC | 1,033,300 | 34,254,000 | 3.00% | Call | |
| 12 | MILLENNIUM MANAGEMENT LLC | 829,574 | 27,500,000 | 2.41% | ||
| 13 | DEUTSCHE BANK AG\ | 804,733 | 26,675,000 | 2.33% | ||
| 14 | PRICE T ROWE ASSOCIATES INC /MD/ | 747,200 | 24,770,000 | 2.17% | ||
| 15 | PUTNAM INVESTMENTS LLC | 717,513 | 23,785,000 | 2.08% | ||
| 16 | FMR LLC | 698,550 | 23,157,000 | 2.03% | ||
| 17 | Rock Springs Capital Management LP | 675,000 | 22,376,000 | 1.96% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 667,129 | 22,115,000 | 1.93% | ||
| 19 | WALL STREET ASSOCIATES | 550,795 | 18,259,000 | 1.60% | ||
| 20 | Opaleye Management Inc. | 460,000 | 15,249,000 | 1.33% | ||
| 21 | Bank of New York Mellon Corp | 454,735 | 15,075,000 | 1.32% | ||
| 22 | EcoR1 Capital, LLC | 341,650 | 11,326,000 | 0.99% | ||
| 23 | Park West Asset Management LLC | 328,753 | 10,898,000 | 0.95% | ||
| 24 | WELLS FARGO & COMPANY/MN | 319,425 | 10,588,000 | 0.93% | ||
| 25 | NORTHERN TRUST CORP | 304,942 | 10,109,000 | 0.88% | ||
| 26 | TAMRO Capital Partners LLC | 253,159 | 8,392,000 | 0.73% | ||
| 27 | CASTLEARK MANAGEMENT LLC | 243,650 | 8,077,000 | 0.71% | ||
| 28 | Point72 Asset Management, L.P. | 243,300 | 8,065,000 | 0.71% | ||
| 29 | BNP Paribas Asset Management Holding S.A. | 241,493 | 8,005,000 | 0.70% | ||
| 30 | Invesco Ltd. | 239,423 | 7,937,000 | 0.69% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 229,200 | 7,598,000 | 0.66% | Call | |
| 32 | Laurion Capital Management LP | 227,898 | 7,555,000 | 0.66% | ||
| 33 | MORGAN STANLEY | 222,124 | 7,363,000 | 0.64% | ||
| 34 | GEODE CAPITAL MANAGEMENT, LLC | 221,308 | 7,336,000 | 0.64% | ||
| 35 | MACQUARIE GROUP LTD | 210,803 | 6,988,000 | 0.61% | ||
| 36 | SENZAR ASSET MANAGEMENT, LLC | 209,500 | 6,945,000 | 0.61% | ||
| 37 | TEACHERS ADVISORS, LLC | 171,391 | 5,682,000 | 0.50% | ||
| 38 | NEXT CENTURY GROWTH INVESTORS LLC | 170,372 | 5,647,000 | 0.49% | ||
| 39 | EVENTIDE ASSET MANAGEMENT, LLC | 165,100 | 5,473,000 | 0.48% | ||
| 40 | LORD, ABBETT & CO. LLC | 164,434 | 5,451,000 | 0.48% | ||
| 41 | Connor, Clark & Lunn Investment Management Ltd. | 153,350 | 5,084,000 | 0.44% | ||
| 42 | Telemetry Investments, L.L.C. | 150,500 | 4,989,000 | 0.44% | ||
| 43 | AQR CAPITAL MANAGEMENT LLC | 143,635 | 4,762,000 | 0.42% | ||
| 44 | TURNER INVESTMENTS LLC | 143,240 | 4,748,000 | 0.42% | ||
| 45 | Numeric Investors LLC | 141,043 | 4,676,000 | 0.41% | ||
| 46 | TIAA CREF INVESTMENT MANAGEMENT LLC | 137,028 | 4,542,000 | 0.40% | ||
| 47 | BlackRock Investment Management, LLC | 118,538 | 3,930,000 | 0.34% | ||
| 48 | EverPoint Asset Management, LLC | 115,000 | 3,812,000 | 0.33% | ||
| 49 | CITADEL ADVISORS LLC | 113,681 | 3,769,000 | 0.33% | ||
| 50 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 102,308 | 3,392,000 | 0.30% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
