| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | SCOPIA CAPITAL MANAGEMENT LP | 3,598,222 | 49,152,000 | 9.06% | ||
| 2 | PERCEPTIVE ADVISORS LLC | 2,999,380 | 40,971,000 | 7.56% | ||
| 3 | Broadfin Capital, LLC | 2,959,790 | 40,431,000 | 7.46% | ||
| 4 | Consonance Capital Management LP | 2,729,947 | 37,291,000 | 6.88% | ||
| 5 | JENNISON ASSOCIATES LLC | 2,265,108 | 30,941,000 | 5.71% | ||
| 6 | BlackRock Fund Advisors | 1,302,989 | 17,799,000 | 3.28% | ||
| 7 | Lombard Odier Asset Management (USA) Corp | 1,279,723 | 17,481,000 | 3.22% | ||
| 8 | FRANKLIN RESOURCES INC | 1,267,950 | 17,320,000 | 3.19% | ||
| 9 | FMR LLC | 1,230,318 | 16,806,000 | 3.10% | ||
| 10 | EcoR1 Capital, LLC | 1,225,084 | 16,735,000 | 3.09% | ||
| 11 | GOLDMAN SACHS GROUP INC | 1,209,700 | 16,525,000 | 3.05% | Put | |
| 12 | VANGUARD GROUP INC | 1,186,479 | 16,207,000 | 2.99% | ||
| 13 | STATE STREET CORP | 1,130,386 | 15,438,000 | 2.85% | ||
| 14 | SENZAR ASSET MANAGEMENT, LLC | 1,114,592 | 15,225,327 | 2.81% | ||
| 15 | Amici Capital, LLC | 918,138 | 12,542,000 | 2.31% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 889,481 | 12,150,000 | 2.24% | ||
| 17 | GOLDMAN SACHS GROUP INC | 822,427 | 11,234,000 | 2.07% | ||
| 18 | Invesco Ltd. | 763,826 | 10,434,000 | 1.92% | ||
| 19 | PRICE T ROWE ASSOCIATES INC /MD/ | 723,789 | 9,887,000 | 1.82% | ||
| 20 | DEUTSCHE BANK AG\ | 561,494 | 7,668,000 | 1.41% | ||
| 21 | Bank of New York Mellon Corp | 538,894 | 7,362,000 | 1.36% | ||
| 22 | Rock Springs Capital Management LP | 521,400 | 7,122,000 | 1.31% | ||
| 23 | MACQUARIE GROUP LTD | 521,035 | 7,117,000 | 1.31% | ||
| 24 | Park West Asset Management LLC | 480,589 | 6,565,000 | 1.21% | ||
| 25 | NORTHERN TRUST CORP | 393,891 | 5,380,000 | 0.99% | ||
| 26 | Spark Investment Management LLC | 393,300 | 5,372,000 | 0.99% | ||
| 27 | MILLENNIUM MANAGEMENT LLC | 342,830 | 4,683,000 | 0.86% | ||
| 28 | Amici Capital, LLC | 340,400 | 4,650,000 | 0.86% | Call | |
| 29 | Tekla Capital Management LLC | 329,949 | 4,507,000 | 0.83% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 262,729 | 3,588,000 | 0.66% | ||
| 31 | TEACHERS ADVISORS, LLC | 231,492 | 3,162,000 | 0.58% | ||
| 32 | OXFORD ASSET MANAGEMENT LLP | 207,762 | 2,838,000 | 0.52% | ||
| 33 | ACUTA CAPITAL PARTNERS, LLC | 200,000 | 2,732,000 | 0.50% | ||
| 34 | WALL STREET ASSOCIATES | 198,695 | 2,714,000 | 0.50% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 194,600 | 2,658,000 | 0.49% | Call | |
| 36 | Telemetry Investments, L.L.C. | 164,153 | 2,242,000 | 0.41% | ||
| 37 | CITADEL ADVISORS LLC | 162,552 | 2,221,000 | 0.41% | ||
| 38 | SABBY MANAGEMENT, LLC | 156,774 | 2,142,000 | 0.40% | ||
| 39 | Opaleye Management Inc. | 150,000 | 2,049,000 | 0.38% | ||
| 40 | Jefferies Group LLC | 150,000 | 2,049,000 | 0.38% | Put | |
| 41 | TURNER INVESTMENTS LLC | 142,864 | 1,952,000 | 0.36% | ||
| 42 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 141,800 | 1,937,000 | 0.36% | Put | |
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 132,300 | 1,807,000 | 0.33% | Put | |
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 126,641 | 1,730,000 | 0.32% | ||
| 45 | CLOVIS CAPITAL MANAGEMENT LP | 122,794 | 1,677,000 | 0.31% | ||
| 46 | BlackRock Investment Management, LLC | 119,703 | 1,635,000 | 0.30% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 118,881 | 1,624,000 | 0.30% | ||
| 48 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 118,198 | 1,614,000 | 0.30% | ||
| 49 | Connor, Clark & Lunn Investment Management Ltd. | 109,750 | 1,499,000 | 0.28% | ||
| 50 | TWO SIGMA INVESTMENTS, LP | 103,217 | 1,410,000 | 0.26% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
