| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JENNISON ASSOCIATES LLC | 3,147,293 | 38,523,000 | 14.34% | ||
| 2 | Broadfin Capital, LLC | 2,658,854 | 32,544,000 | 12.11% | ||
| 3 | Consonance Capital Management LP | 2,551,535 | 31,231,000 | 11.62% | ||
| 4 | PERCEPTIVE ADVISORS LLC | 1,940,725 | 23,754,000 | 8.84% | ||
| 5 | Lombard Odier Asset Management (USA) Corp | 1,750,000 | 21,420,000 | 7.97% | ||
| 6 | QVT Financial LP | 1,267,710 | 15,166,000 | 5.64% | ||
| 7 | Opaleye Management Inc. | 920,000 | 11,261,000 | 4.19% | ||
| 8 | BlackRock Fund Advisors | 911,454 | 11,156,000 | 4.15% | ||
| 9 | PUTNAM INVESTMENTS LLC | 848,775 | 10,389,000 | 3.87% | ||
| 10 | Amici Capital, LLC | 707,000 | 8,654,000 | 3.22% | ||
| 11 | VANGUARD GROUP INC | 639,682 | 7,829,000 | 2.91% | ||
| 12 | SENZAR ASSET MANAGEMENT, LLC | 635,700 | 7,781,000 | 2.90% | ||
| 13 | DEUTSCHE BANK AG\ | 387,423 | 4,741,000 | 1.76% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 315,905 | 3,867,000 | 1.44% | ||
| 15 | STATE STREET CORP | 291,746 | 3,572,000 | 1.33% | ||
| 16 | Round Table Services, LLC | 275,852 | 3,376,000 | 1.26% | ||
| 17 | Visium Asset Management, LP | 256,408 | 3,139,000 | 1.17% | ||
| 18 | TURNER INVESTMENTS LLC | 229,580 | 2,810,000 | 1.05% | ||
| 19 | NORTHERN TRUST CORP | 212,585 | 2,602,000 | 0.97% | ||
| 20 | GOLDMAN SACHS GROUP INC | 208,799 | 2,556,000 | 0.95% | ||
| 21 | Laurion Capital Management LP | 187,179 | 2,291,000 | 0.85% | ||
| 22 | GOLDMAN SACHS GROUP INC | 150,000 | 1,836,000 | 0.68% | Call | |
| 23 | Connor, Clark & Lunn Investment Management Ltd. | 139,600 | 1,709,000 | 0.64% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 129,032 | 1,579,000 | 0.59% | ||
| 25 | Bank of New York Mellon Corp | 101,026 | 1,236,000 | 0.46% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 97,800 | 1,197,000 | 0.45% | Call | |
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 89,768 | 1,099,000 | 0.41% | ||
| 28 | WALL STREET ASSOCIATES | 85,500 | 1,047,000 | 0.39% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 70,141 | 859,000 | 0.32% | ||
| 30 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 67,900 | 831,000 | 0.31% | ||
| 31 | BlackRock Investment Management, LLC | 60,742 | 743,000 | 0.28% | ||
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 52,388 | 642,000 | 0.24% | ||
| 33 | D. E. Shaw & Co., Inc. | 45,600 | 558,000 | 0.21% | ||
| 34 | AQR CAPITAL MANAGEMENT LLC | 40,600 | 497,000 | 0.18% | ||
| 35 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 39,291 | 481,000 | 0.18% | ||
| 36 | Cubist Systematic Strategies, LLC | 36,762 | 450,000 | 0.17% | ||
| 37 | ARMISTICE CAPITAL, LLC | 34,874 | 427,000 | 0.16% | ||
| 38 | ASCEND CAPITAL, LLC | 31,850 | 391,000 | 0.15% | ||
| 39 | CREDIT SUISSE AG/ | 31,083 | 381,000 | 0.14% | ||
| 40 | TEACHERS ADVISORS, LLC | 28,618 | 350,000 | 0.13% | ||
| 41 | MORGAN STANLEY | 23,495 | 287,000 | 0.11% | ||
| 42 | CITADEL ADVISORS LLC | 22,425 | 274,000 | 0.10% | ||
| 43 | ProShare Advisors LLC | 22,252 | 272,000 | 0.10% | ||
| 44 | METROPOLITAN LIFE INSURANCE CO/NY | 20,202 | 247,000 | 0.09% | ||
| 45 | DIMENSIONAL FUND ADVISORS LP | 19,961 | 244,000 | 0.09% | ||
| 46 | Telemetry Investments, L.L.C. | 18,500 | 226,000 | 0.08% | ||
| 47 | RHUMBLINE ADVISERS | 17,663 | 216,000 | 0.08% | ||
| 48 | JW Asset Management, LLC | 16,459 | 202,000 | 0.08% | ||
| 49 | Nationwide Fund Advisors | 15,895 | 195,000 | 0.07% | ||
| 50 | VOYA INVESTMENT MANAGEMENT LLC | 15,292 | 187,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
