| 1 |
VIVO CAPITAL, LLC |
5,573,319 |
17,333,000 |
27.57% |
|
|
| 2 |
Nantahala Capital Management, LLC |
5,014,509 |
15,595,000 |
24.80% |
|
|
| 3 |
FMR LLC |
2,095,715 |
6,517,000 |
10.36% |
|
|
| 4 |
Opaleye Management Inc. |
1,178,500 |
3,665,000 |
5.83% |
|
|
| 5 |
BlackRock Institutional Trust Company, N.A. |
1,124,338 |
3,497,000 |
5.56% |
|
|
| 6 |
BAILLIE GIFFORD & CO |
985,133 |
3,064,000 |
4.87% |
|
|
| 7 |
VANGUARD GROUP INC |
820,019 |
2,551,000 |
4.06% |
|
|
| 8 |
RENAISSANCE TECHNOLOGIES LLC |
807,000 |
2,510,000 |
3.99% |
|
|
| 9 |
Granite Investment Partners, LLC |
359,629 |
1,118,000 |
1.78% |
|
|
| 10 |
Informed Momentum Co LLC |
308,232 |
959,000 |
1.53% |
|
|
| 11 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
265,500 |
826,000 |
1.31% |
|
|
| 12 |
Spark Investment Management LLC |
156,798 |
487,000 |
0.77% |
|
|
| 13 |
ESSEX INVESTMENT MANAGEMENT CO LLC |
148,630 |
462,000 |
0.73% |
|
|
| 14 |
GEODE CAPITAL MANAGEMENT, LLC |
139,587 |
434,000 |
0.69% |
|
|
| 15 |
UBS Group AG |
93,750 |
292,000 |
0.46% |
|
|
| 16 |
OXFORD ASSET MANAGEMENT LLP |
89,815 |
279,000 |
0.44% |
|
|
| 17 |
GSA CAPITAL PARTNERS LLP |
89,723 |
279,000 |
0.44% |
|
|
| 18 |
BlackRock Fund Advisors |
82,817 |
258,000 |
0.41% |
|
|
| 19 |
DIMENSIONAL FUND ADVISORS LP |
81,295 |
253,000 |
0.40% |
|
|
| 20 |
AXA S.A. |
65,052 |
202,000 |
0.32% |
|
|
| 21 |
GOLDMAN SACHS GROUP INC |
58,399 |
182,000 |
0.29% |
|
|
| 22 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
55,520 |
173,000 |
0.28% |
|
|
| 23 |
Bank of New York Mellon Corp |
55,181 |
172,000 |
0.27% |
|
|
| 24 |
MORGAN STANLEY |
51,925 |
161,000 |
0.26% |
|
|
| 25 |
NORTHERN TRUST CORP |
50,279 |
156,000 |
0.25% |
|
|
| 26 |
ALAMBIC INVESTMENT MANAGEMENT, L.P. |
49,512 |
154,000 |
0.24% |
|
|
| 27 |
CREDIT SUISSE AG/ |
47,772 |
149,000 |
0.24% |
|
|
| 28 |
MILLENNIUM MANAGEMENT LLC |
47,495 |
148,000 |
0.24% |
|
|
| 29 |
MENTA CAPITAL LLC |
41,378 |
129,000 |
0.21% |
|
|
| 30 |
JPMORGAN CHASE & CO |
38,026 |
118,000 |
0.19% |
|
|
| 31 |
Segantii Capital Management Ltd |
30,300 |
95,000 |
0.15% |
|
|
| 32 |
BANK OF AMERICA CORP /DE/ |
24,463 |
76,000 |
0.12% |
|
|
| 33 |
BlueCrest Capital Management Ltd |
21,577 |
67,000 |
0.11% |
|
|
| 34 |
DEUTSCHE BANK AG\ |
20,933 |
64,000 |
0.10% |
|
|
| 35 |
PDT Partners, LLC |
19,031 |
59,000 |
0.09% |
|
|
| 36 |
FRANKLIN STREET ADVISORS INC /NC |
19,100 |
59,000 |
0.09% |
|
|
| 37 |
SG Americas Securities, LLC |
15,900 |
49,000 |
0.08% |
|
|
| 38 |
Verition Fund Management LLC |
15,615 |
49,000 |
0.08% |
|
|
| 39 |
Tower Research Capital LLC (TRC) |
13,219 |
41,000 |
0.07% |
|
|
| 40 |
A.R.T. Advisors, LLC |
12,467 |
38,000 |
0.06% |
|
|
| 41 |
Jefferies Group LLC |
11,800 |
37,000 |
0.06% |
|
|
| 42 |
Connor, Clark & Lunn Investment Management Ltd. |
11,044 |
34,000 |
0.05% |
|
|
| 43 |
STIFEL FINANCIAL CORP |
10,000 |
31,000 |
0.05% |
|
|
| 44 |
BlackRock Investment Management, LLC |
5,702 |
18,000 |
0.03% |
|
|
| 45 |
WELLS FARGO & COMPANY/MN |
5,788 |
18,000 |
0.03% |
|
|
| 46 |
MUFG Americas Holdings Corp |
2,217 |
7,000 |
0.01% |
|
|
| 47 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
2,041 |
6,000 |
0.01% |
|
|
| 48 |
MAGEE THOMSON INVESTMENT PARTNERS LLC |
942 |
4,000 |
0.01% |
|
|
| 49 |
Financial Architects, Inc |
1,000 |
3,000 |
0.00% |
|
|
| 50 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
167 |
1,000 |
0.00% |
|
|
