| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,718,364 | 160,283,000 | 22.52% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,271,727 | 111,141,000 | 15.62% | ||
| 3 | Polaris Venture Management Co IV LLC | 2,803,645 | 95,240,000 | 13.38% | ||
| 4 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,520,666 | 51,657,000 | 7.26% | ||
| 5 | QVT Financial LP | 1,154,058 | 39,203,000 | 5.51% | ||
| 6 | VANGUARD GROUP INC | 686,528 | 23,322,000 | 3.28% | ||
| 7 | FRANKLIN RESOURCES INC | 657,377 | 22,331,000 | 3.14% | ||
| 8 | SECTORAL ASSET MANAGEMENT INC | 589,053 | 20,010,000 | 2.81% | ||
| 9 | STATE STREET CORP | 552,445 | 18,769,000 | 2.64% | ||
| 10 | JPMORGAN CHASE & CO | 478,306 | 16,249,000 | 2.28% | ||
| 11 | LOOMIS SAYLES & CO L P | 411,781 | 13,988,000 | 1.97% | ||
| 12 | BlackRock Fund Advisors | 362,428 | 12,312,000 | 1.73% | ||
| 13 | PERCEPTIVE ADVISORS LLC | 300,000 | 10,191,000 | 1.43% | ||
| 14 | Invesco Ltd. | 283,027 | 9,614,000 | 1.35% | ||
| 15 | BLACKROCK ADVISORS LLC | 236,743 | 8,042,000 | 1.13% | ||
| 16 | Cormorant Asset Management, LP | 200,000 | 6,794,000 | 0.95% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 182,121 | 6,187,000 | 0.87% | ||
| 18 | Deer VII & Co. Ltd. | 175,075 | 5,947,000 | 0.84% | ||
| 19 | ORBIMED ADVISORS LLC | 171,800 | 5,836,000 | 0.82% | ||
| 20 | DRIEHAUS CAPITAL MANAGEMENT LLC | 164,282 | 5,581,000 | 0.78% | ||
| 21 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 120,800 | 4,104,000 | 0.58% | ||
| 22 | LORD, ABBETT & CO. LLC | 120,683 | 4,100,000 | 0.58% | ||
| 23 | Iguana Healthcare Management, LLC | 110,000 | 3,737,000 | 0.53% | ||
| 24 | NORTHERN TRUST CORP | 100,961 | 3,430,000 | 0.48% | ||
| 25 | WALL STREET ASSOCIATES | 93,100 | 3,163,000 | 0.44% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 73,515 | 2,497,000 | 0.35% | ||
| 27 | TEACHERS ADVISORS, LLC | 69,697 | 2,368,000 | 0.33% | ||
| 28 | VOYA INVESTMENT MANAGEMENT LLC | 69,417 | 2,358,000 | 0.33% | ||
| 29 | EVENTIDE ASSET MANAGEMENT, LLC | 62,100 | 2,110,000 | 0.30% | ||
| 30 | Bank of New York Mellon Corp | 60,652 | 2,061,000 | 0.29% | ||
| 31 | DEUTSCHE BANK AG\ | 58,947 | 2,001,000 | 0.28% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 57,054 | 1,938,000 | 0.27% | ||
| 33 | BlackRock Investment Management, LLC | 56,822 | 1,930,000 | 0.27% | ||
| 34 | TD ASSET MANAGEMENT INC | 55,800 | 1,896,000 | 0.27% | ||
| 35 | Foresite Capital Management I, LLC | 55,767 | 1,894,000 | 0.27% | ||
| 36 | BlackRock Group LTD | 54,100 | 1,838,000 | 0.26% | ||
| 37 | JENNISON ASSOCIATES LLC | 49,788 | 1,691,000 | 0.24% | ||
| 38 | PDT Partners, LLC | 49,761 | 1,690,000 | 0.24% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 44,000 | 1,495,000 | 0.21% | Call | |
| 40 | CREDIT SUISSE AG/ | 39,856 | 1,354,000 | 0.19% | ||
| 41 | PRINCIPAL FINANCIAL GROUP INC | 39,800 | 1,352,000 | 0.19% | ||
| 42 | PICTET ASSET MANAGEMENT LTD | 38,500 | 1,308,000 | 0.18% | ||
| 43 | GUGGENHEIM CAPITAL LLC | 37,552 | 1,276,000 | 0.18% | ||
| 44 | PEAK6 Group LLC | 32,500 | 1,104,000 | 0.16% | Call | |
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 30,000 | 1,019,000 | 0.14% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 29,039 | 987,000 | 0.14% | ||
| 47 | BAKER BROS. ADVISORS LP | 28,765 | 977,000 | 0.14% | ||
| 48 | ALLIANCEBERNSTEIN L.P. | 25,500 | 866,000 | 0.12% | ||
| 49 | MILLENNIUM MANAGEMENT LLC | 23,051 | 783,000 | 0.11% | ||
| 50 | MORGAN STANLEY | 22,823 | 775,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
