| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,769,562 | 144,232,000 | 22.48% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,235,055 | 97,828,000 | 15.25% | ||
| 3 | Polaris Venture Management Co IV LLC | 2,803,645 | 84,782,000 | 13.21% | ||
| 4 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,747,406 | 52,842,000 | 8.24% | ||
| 5 | QVT Financial LP | 1,193,258 | 36,084,000 | 5.62% | ||
| 6 | VANGUARD GROUP INC | 735,327 | 22,236,000 | 3.47% | ||
| 7 | SECTORAL ASSET MANAGEMENT INC | 726,424 | 21,967,000 | 3.42% | ||
| 8 | FRANKLIN RESOURCES INC | 544,577 | 16,468,000 | 2.57% | ||
| 9 | JPMORGAN CHASE & CO | 534,884 | 16,175,000 | 2.52% | ||
| 10 | PERCEPTIVE ADVISORS LLC | 445,000 | 13,457,000 | 2.10% | ||
| 11 | LOOMIS SAYLES & CO L P | 401,170 | 12,131,000 | 1.89% | ||
| 12 | Cormorant Asset Management, LP | 400,000 | 12,096,000 | 1.89% | ||
| 13 | BlackRock Fund Advisors | 355,415 | 10,748,000 | 1.68% | ||
| 14 | CITADEL ADVISORS LLC | 345,411 | 10,445,000 | 1.63% | ||
| 15 | STATE STREET CORP | 215,192 | 6,507,000 | 1.01% | ||
| 16 | BLACKROCK ADVISORS LLC | 212,537 | 6,427,000 | 1.00% | ||
| 17 | Deer VII & Co. Ltd. | 175,075 | 5,294,000 | 0.83% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 170,396 | 5,153,000 | 0.80% | ||
| 19 | NORTHERN TRUST CORP | 166,660 | 5,039,000 | 0.79% | ||
| 20 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 115,700 | 3,499,000 | 0.55% | ||
| 21 | SPHERA FUNDS MANAGEMENT LTD. | 100,000 | 3,024,000 | 0.47% | ||
| 22 | DRIEHAUS CAPITAL MANAGEMENT LLC | 99,541 | 3,010,000 | 0.47% | ||
| 23 | DEUTSCHE BANK AG\ | 94,841 | 2,866,000 | 0.45% | ||
| 24 | LORD, ABBETT & CO. LLC | 85,667 | 2,591,000 | 0.40% | ||
| 25 | WALL STREET ASSOCIATES | 83,200 | 2,516,000 | 0.39% | ||
| 26 | OAK RIDGE INVESTMENTS LLC | 73,351 | 2,218,000 | 0.35% | ||
| 27 | TEACHERS ADVISORS, LLC | 69,697 | 2,108,000 | 0.33% | ||
| 28 | Bank of New York Mellon Corp | 67,660 | 2,046,000 | 0.32% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 65,400 | 1,977,000 | 0.31% | ||
| 30 | EVENTIDE ASSET MANAGEMENT, LLC | 62,100 | 1,878,000 | 0.29% | ||
| 31 | TIAA CREF INVESTMENT MANAGEMENT LLC | 60,188 | 1,820,000 | 0.28% | ||
| 32 | BlackRock Investment Management, LLC | 57,014 | 1,724,000 | 0.27% | ||
| 33 | Foresite Capital Management I, LLC | 55,767 | 1,686,000 | 0.26% | ||
| 34 | TD ASSET MANAGEMENT INC | 55,400 | 1,675,000 | 0.26% | ||
| 35 | ALLIANCEBERNSTEIN L.P. | 54,797 | 1,657,000 | 0.26% | ||
| 36 | BlackRock Group LTD | 54,626 | 1,652,000 | 0.26% | ||
| 37 | JENNISON ASSOCIATES LLC | 49,863 | 1,508,000 | 0.24% | ||
| 38 | Numeric Investors LLC | 49,687 | 1,503,000 | 0.23% | ||
| 39 | PICTET ASSET MANAGEMENT LTD | 45,600 | 1,379,000 | 0.21% | ||
| 40 | THRIVENT FINANCIAL FOR LUTHERANS | 40,300 | 1,219,000 | 0.19% | ||
| 41 | PRINCIPAL FINANCIAL GROUP INC | 39,800 | 1,204,000 | 0.19% | ||
| 42 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 35,400 | 1,070,000 | 0.17% | Put | |
| 43 | GUGGENHEIM CAPITAL LLC | 35,038 | 1,060,000 | 0.17% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 35,000 | 1,058,000 | 0.16% | Call | |
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 30,372 | 918,000 | 0.14% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 29,345 | 888,000 | 0.14% | ||
| 47 | BAKER BROS. ADVISORS LP | 28,765 | 870,000 | 0.14% | ||
| 48 | SMITH ASSET MANAGEMENT GROUP LP | 27,400 | 828,000 | 0.13% | ||
| 49 | CREDIT SUISSE AG/ | 26,214 | 793,000 | 0.12% | ||
| 50 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 25,300 | 765,000 | 0.12% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
