| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,987,985 | 243,214,000 | 19.61% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,929,479 | 142,841,000 | 11.52% | ||
| 3 | OAK RIDGE INVESTMENTS LLC | 1,522,967 | 74,259,000 | 5.99% | ||
| 4 | Polaris Venture Management Co IV LLC | 1,480,060 | 72,168,000 | 5.82% | ||
| 5 | VANGUARD GROUP INC | 1,264,386 | 61,651,000 | 4.97% | ||
| 6 | SECTORAL ASSET MANAGEMENT INC | 1,121,264 | 54,673,000 | 4.41% | ||
| 7 | BlackRock Fund Advisors | 920,917 | 44,904,000 | 3.62% | ||
| 8 | JPMORGAN CHASE & CO | 838,760 | 40,898,000 | 3.30% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 702,177 | 34,238,000 | 2.76% | ||
| 10 | Granahan Investment Management, LLC | 656,391 | 32,006,000 | 2.58% | ||
| 11 | QVT Financial LP | 640,300 | 31,221,000 | 2.52% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 555,680 | 27,095,000 | 2.19% | ||
| 13 | STATE STREET CORP | 516,603 | 25,196,000 | 2.03% | ||
| 14 | BLACKROCK ADVISORS LLC | 508,816 | 24,810,000 | 2.00% | ||
| 15 | FRANKLIN RESOURCES INC | 495,200 | 24,146,000 | 1.95% | ||
| 16 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 387,500 | 18,895,000 | 1.52% | ||
| 17 | BROWN ADVISORY INC | 283,353 | 13,817,000 | 1.11% | ||
| 18 | PERCEPTIVE ADVISORS LLC | 276,036 | 13,460,000 | 1.09% | ||
| 19 | NORTHERN TRUST CORP | 252,526 | 12,314,000 | 0.99% | ||
| 20 | CITADEL ADVISORS LLC | 221,702 | 10,810,000 | 0.87% | ||
| 21 | DEERFIELD MANAGEMENT COMPANY, L.P. | 213,491 | 10,410,000 | 0.84% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 212,225 | 10,348,000 | 0.83% | ||
| 23 | CLOUGH CAPITAL PARTNERS L P | 207,897 | 10,137,000 | 0.82% | ||
| 24 | Cormorant Asset Management, LP | 200,000 | 9,752,000 | 0.79% | ||
| 25 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 173,224 | 8,447,000 | 0.68% | ||
| 26 | DEUTSCHE BANK AG\ | 168,175 | 8,198,000 | 0.66% | ||
| 27 | LORD, ABBETT & CO. LLC | 151,240 | 7,374,000 | 0.59% | ||
| 28 | GOLDMAN SACHS GROUP INC | 150,000 | 7,314,000 | 0.59% | Put | |
| 29 | GOLDMAN SACHS GROUP INC | 150,000 | 7,314,000 | 0.59% | Call | |
| 30 | Iguana Healthcare Management, LLC | 150,000 | 7,314,000 | 0.59% | ||
| 31 | Foresite Capital Management II, LLC | 137,458 | 6,702,000 | 0.54% | ||
| 32 | PUTNAM INVESTMENTS LLC | 125,000 | 6,095,000 | 0.49% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 124,300 | 6,061,000 | 0.49% | Put | |
| 34 | EVENTIDE ASSET MANAGEMENT, LLC | 123,500 | 6,022,000 | 0.49% | ||
| 35 | Candriam S.C.A. | 120,000 | 5,851,000 | 0.47% | ||
| 36 | BlackRock Group LTD | 116,888 | 5,699,000 | 0.46% | ||
| 37 | TFS CAPITAL LLC | 110,801 | 5,403,000 | 0.44% | ||
| 38 | Bank of New York Mellon Corp | 107,145 | 5,225,000 | 0.42% | ||
| 39 | BlackRock Investment Management, LLC | 104,579 | 5,099,000 | 0.41% | ||
| 40 | FORESITE CAPITAL MANAGEMENT III, LLC | 100,000 | 4,876,000 | 0.39% | Put | |
| 41 | PRINCIPAL FINANCIAL GROUP INC | 99,600 | 4,856,000 | 0.39% | ||
| 42 | CREDIT SUISSE AG/ | 92,360 | 4,503,000 | 0.36% | ||
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 91,329 | 4,454,000 | 0.36% | ||
| 44 | PICTET ASSET MANAGEMENT LTD | 86,100 | 4,198,000 | 0.34% | ||
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 69,324 | 3,380,000 | 0.27% | ||
| 46 | PRUDENTIAL FINANCIAL INC | 68,700 | 3,350,000 | 0.27% | ||
| 47 | TD ASSET MANAGEMENT INC | 63,100 | 3,077,000 | 0.25% | ||
| 48 | SPHERA FUNDS MANAGEMENT LTD. | 60,000 | 2,926,000 | 0.24% | ||
| 49 | VERDE SERVICOS INTERNACIONAIS S.A. | 81,176 | 2,794,000 | 0.23% | ||
| 50 | BANK OF AMERICA CORP /DE/ | 50,329 | 2,454,000 | 0.20% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
