| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,896,648 | 186,366,000 | 19.54% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,174,335 | 120,815,000 | 12.67% | ||
| 3 | Polaris Venture Management Co IV LLC | 2,396,389 | 91,207,000 | 9.56% | ||
| 4 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,200,000 | 45,672,000 | 4.79% | ||
| 5 | OAK RIDGE INVESTMENTS LLC | 1,162,325 | 44,238,000 | 4.64% | ||
| 6 | BlackRock Fund Advisors | 824,732 | 31,389,000 | 3.29% | ||
| 7 | VANGUARD GROUP INC | 790,376 | 30,082,000 | 3.15% | ||
| 8 | QVT Financial LP | 761,661 | 28,989,000 | 3.04% | ||
| 9 | JPMORGAN CHASE & CO | 708,240 | 26,955,000 | 2.83% | ||
| 10 | SECTORAL ASSET MANAGEMENT INC | 599,184 | 22,805,000 | 2.39% | ||
| 11 | AGTC Partners, L.P. | 530,919 | 20,207,000 | 2.12% | ||
| 12 | FRANKLIN RESOURCES INC | 524,277 | 19,954,000 | 2.09% | ||
| 13 | CLOUGH CAPITAL PARTNERS L P | 512,430 | 19,503,000 | 2.05% | ||
| 14 | CITADEL ADVISORS LLC | 484,500 | 18,440,000 | 1.93% | ||
| 15 | PointState Capital LP | 475,000 | 18,079,000 | 1.90% | ||
| 16 | Granahan Investment Management, LLC | 469,776 | 17,880,000 | 1.87% | ||
| 17 | BLACKROCK ADVISORS LLC | 467,976 | 17,811,000 | 1.87% | ||
| 18 | LORD, ABBETT & CO. LLC | 380,669 | 14,488,000 | 1.52% | ||
| 19 | LOOMIS SAYLES & CO L P | 357,413 | 13,603,000 | 1.43% | ||
| 20 | PERCEPTIVE ADVISORS LLC | 336,036 | 12,790,000 | 1.34% | ||
| 21 | BlackRock Institutional Trust Company, N.A. | 292,281 | 11,124,000 | 1.17% | ||
| 22 | BROWN ADVISORY INC | 267,204 | 10,169,000 | 1.07% | ||
| 23 | STATE STREET CORP | 245,460 | 9,343,000 | 0.98% | ||
| 24 | Iguana Healthcare Management, LLC | 175,000 | 6,661,000 | 0.70% | ||
| 25 | Cormorant Asset Management, LP | 170,000 | 6,470,000 | 0.68% | ||
| 26 | NORTHERN TRUST CORP | 163,958 | 6,240,000 | 0.65% | ||
| 27 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 110,700 | 4,213,000 | 0.44% | ||
| 28 | CREDIT SUISSE AG/ | 108,524 | 4,130,000 | 0.43% | ||
| 29 | BlackRock Group LTD | 100,053 | 3,808,000 | 0.40% | ||
| 30 | DEUTSCHE BANK AG\ | 97,485 | 3,709,000 | 0.39% | ||
| 31 | Foresite Capital Management I, LLC | 93,781 | 3,569,000 | 0.37% | ||
| 32 | EVENTIDE ASSET MANAGEMENT, LLC | 87,100 | 3,315,000 | 0.35% | ||
| 33 | Pentwater Capital Management LP | 82,000 | 3,121,000 | 0.33% | ||
| 34 | WALL STREET ASSOCIATES | 79,000 | 3,007,000 | 0.32% | ||
| 35 | BlackRock Investment Management, LLC | 73,586 | 2,801,000 | 0.29% | ||
| 36 | Bank of New York Mellon Corp | 72,032 | 2,741,000 | 0.29% | ||
| 37 | TEACHERS ADVISORS, LLC | 69,597 | 2,649,000 | 0.28% | ||
| 38 | GEODE CAPITAL MANAGEMENT, LLC | 69,242 | 2,635,000 | 0.28% | ||
| 39 | Candriam S.C.A. | 68,000 | 2,589,000 | 0.27% | ||
| 40 | TD ASSET MANAGEMENT INC | 63,400 | 2,413,000 | 0.25% | ||
| 41 | PRINCIPAL FINANCIAL GROUP INC | 63,000 | 2,398,000 | 0.25% | ||
| 42 | ALLIANCEBERNSTEIN L.P. | 60,890 | 2,317,000 | 0.24% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 60,600 | 2,306,000 | 0.24% | Put | |
| 44 | HIGHLAND CAPITAL MANAGEMENT LP | 60,000 | 2,284,000 | 0.24% | ||
| 45 | DRIEHAUS CAPITAL MANAGEMENT LLC | 57,715 | 2,197,000 | 0.23% | ||
| 46 | TIAA CREF INVESTMENT MANAGEMENT LLC | 57,406 | 2,185,000 | 0.23% | ||
| 47 | Jefferies Group LLC | 49,700 | 1,892,000 | 0.20% | Put | |
| 48 | Jefferies Group LLC | 49,700 | 1,892,000 | 0.20% | Call | |
| 49 | MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 43,453 | 1,654,000 | 0.17% | ||
| 50 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 39,237 | 1,494,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
