| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,567,185 | 189,173,000 | 18.43% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,144,199 | 106,840,000 | 10.41% | ||
| 3 | VANGUARD GROUP INC | 1,646,234 | 55,939,000 | 5.45% | ||
| 4 | Polaris Venture Management Co IV LLC | 1,480,060 | 50,292,000 | 4.90% | ||
| 5 | OAK RIDGE INVESTMENTS LLC | 1,341,831 | 45,596,000 | 4.44% | ||
| 6 | BlackRock Fund Advisors | 1,128,078 | 38,332,000 | 3.73% | ||
| 7 | JPMORGAN CHASE & CO | 799,699 | 27,173,000 | 2.65% | ||
| 8 | Granahan Investment Management, LLC | 759,619 | 25,812,000 | 2.51% | ||
| 9 | STATE STREET CORP | 740,403 | 25,163,000 | 2.45% | ||
| 10 | PICTET ASSET MANAGEMENT LTD | 727,427 | 24,885,000 | 2.42% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 730,806 | 24,833,000 | 2.42% | ||
| 12 | EAGLE ASSET MANAGEMENT INC | 723,829 | 24,595,000 | 2.40% | ||
| 13 | QVT Financial LP | 702,410 | 23,868,000 | 2.32% | ||
| 14 | Novo Holdings A/S | 685,863 | 23,306,000 | 2.27% | ||
| 15 | BLACKROCK ADVISORS LLC | 648,917 | 22,050,000 | 2.15% | ||
| 16 | PERCEPTIVE ADVISORS LLC | 603,036 | 20,491,000 | 2.00% | ||
| 17 | SECTORAL ASSET MANAGEMENT INC | 522,294 | 17,748,000 | 1.73% | ||
| 18 | FRANKLIN RESOURCES INC | 494,777 | 16,813,000 | 1.64% | ||
| 19 | WESTFIELD CAPITAL MANAGEMENT CO LP | 494,200 | 16,793,000 | 1.64% | ||
| 20 | EVENTIDE ASSET MANAGEMENT, LLC | 428,900 | 14,574,000 | 1.42% | ||
| 21 | GOLDMAN SACHS GROUP INC | 416,874 | 14,165,000 | 1.38% | ||
| 22 | CREDIT SUISSE AG/ | 389,653 | 13,240,000 | 1.29% | ||
| 23 | DEUTSCHE BANK AG\ | 373,247 | 12,680,000 | 1.24% | ||
| 24 | EcoR1 Capital, LLC | 371,381 | 12,620,000 | 1.23% | ||
| 25 | NORTHERN TRUST CORP | 314,990 | 10,704,000 | 1.04% | ||
| 26 | BROWN ADVISORY INC | 297,266 | 10,100,000 | 0.98% | ||
| 27 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 287,500 | 9,769,000 | 0.95% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 246,359 | 8,371,000 | 0.82% | ||
| 29 | BlackRock Group LTD | 191,044 | 6,492,000 | 0.63% | ||
| 30 | NORGES BANK | 189,916 | 6,453,000 | 0.63% | ||
| 31 | CITADEL ADVISORS LLC | 169,640 | 5,764,000 | 0.56% | ||
| 32 | Century Capital Management, LLC | 151,523 | 5,149,000 | 0.50% | ||
| 33 | LORD, ABBETT & CO. LLC | 144,933 | 4,925,000 | 0.48% | ||
| 34 | Bank of New York Mellon Corp | 137,689 | 4,679,000 | 0.46% | ||
| 35 | BlackRock Investment Management, LLC | 134,458 | 4,569,000 | 0.45% | ||
| 36 | Cormorant Asset Management, LP | 127,451 | 4,331,000 | 0.42% | ||
| 37 | PUTNAM INVESTMENTS LLC | 125,000 | 4,248,000 | 0.41% | ||
| 38 | VERDE SERVICOS INTERNACIONAIS S.A. | 123,065 | 4,181,000 | 0.41% | ||
| 39 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 112,057 | 3,808,000 | 0.37% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 100,192 | 3,405,000 | 0.33% | ||
| 41 | GOLDMAN SACHS GROUP INC | 100,000 | 3,398,000 | 0.33% | Put | |
| 42 | Artal Group S.A. | 100,000 | 3,398,000 | 0.33% | ||
| 43 | NEXTHERA CAPITAL LP | 99,000 | 3,364,000 | 0.33% | ||
| 44 | PRINCIPAL FINANCIAL GROUP INC | 97,100 | 3,299,000 | 0.32% | ||
| 45 | OXFORD ASSET MANAGEMENT LLP | 86,261 | 2,931,000 | 0.29% | ||
| 46 | PRUDENTIAL FINANCIAL INC | 81,500 | 2,770,000 | 0.27% | ||
| 47 | Candriam S.C.A. | 80,000 | 2,719,000 | 0.26% | ||
| 48 | TD ASSET MANAGEMENT INC | 62,000 | 2,107,000 | 0.21% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 57,469 | 1,953,000 | 0.19% | ||
| 50 | TFS CAPITAL LLC | 57,148 | 1,942,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
