| 1 |
Polaris Venture Management Co IV LLC |
3,317,136 |
114,441,000 |
19.39% |
|
|
| 2 |
FMR LLC |
2,602,777 |
89,796,000 |
15.21% |
|
|
| 3 |
ORBIMED ADVISORS LLC |
1,867,800 |
64,439,000 |
10.92% |
|
|
| 4 |
PRICE T ROWE ASSOCIATES INC /MD/ |
1,843,843 |
63,613,000 |
10.78% |
|
|
| 5 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
1,342,197 |
46,306,000 |
7.85% |
|
|
| 6 |
Deer VII & Co. Ltd. |
1,105,964 |
38,156,000 |
6.46% |
|
|
| 7 |
FRANKLIN RESOURCES INC |
728,577 |
25,136,000 |
4.26% |
|
|
| 8 |
QVT Financial LP |
556,574 |
18,811,000 |
3.19% |
|
|
| 9 |
JPMORGAN CHASE & CO |
505,954 |
17,456,000 |
2.96% |
|
|
| 10 |
VANGUARD GROUP INC |
386,708 |
13,342,000 |
2.26% |
|
|
| 11 |
LOOMIS SAYLES & CO L P |
288,374 |
9,949,000 |
1.69% |
|
|
| 12 |
Invesco Ltd. |
241,500 |
8,332,000 |
1.41% |
|
|
| 13 |
BLACKROCK ADVISORS LLC |
228,919 |
7,898,000 |
1.34% |
|
|
| 14 |
BlackRock Fund Advisors |
200,099 |
6,903,000 |
1.17% |
|
|
| 15 |
DRIEHAUS CAPITAL MANAGEMENT LLC |
124,001 |
4,278,000 |
0.72% |
|
|
| 16 |
D. E. Shaw & Co., Inc. |
123,801 |
4,271,000 |
0.72% |
|
|
| 17 |
LORD, ABBETT & CO. LLC |
110,365 |
3,808,000 |
0.65% |
|
|
| 18 |
STATE STREET CORP |
107,479 |
3,705,000 |
0.63% |
|
|
| 19 |
AQR CAPITAL MANAGEMENT LLC |
105,000 |
3,623,000 |
0.61% |
|
|
| 20 |
WALL STREET ASSOCIATES |
92,800 |
3,202,000 |
0.54% |
|
|
| 21 |
NORTHERN TRUST CORP |
86,615 |
2,989,000 |
0.51% |
|
|
| 22 |
BlackRock Institutional Trust Company, N.A. |
81,000 |
2,795,000 |
0.47% |
|
|
| 23 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
72,583 |
2,504,000 |
0.42% |
|
|
| 24 |
VOYA INVESTMENT MANAGEMENT LLC |
67,866 |
2,341,000 |
0.40% |
|
|
| 25 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
64,600 |
2,229,000 |
0.38% |
|
|
| 26 |
ASCEND CAPITAL, LLC |
63,000 |
2,173,000 |
0.37% |
|
|
| 27 |
TEACHERS ADVISORS, LLC |
57,698 |
1,991,000 |
0.34% |
|
|
| 28 |
JENNISON ASSOCIATES LLC |
55,553 |
1,917,000 |
0.32% |
|
|
| 29 |
BlackRock Group LTD |
54,907 |
1,895,000 |
0.32% |
|
|
| 30 |
GEODE CAPITAL MANAGEMENT, LLC |
50,333 |
1,736,000 |
0.29% |
|
|
| 31 |
PRINCIPAL FINANCIAL GROUP INC |
39,800 |
1,373,000 |
0.23% |
|
|
| 32 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
37,141 |
1,281,000 |
0.22% |
|
|
| 33 |
Bank of New York Mellon Corp |
32,795 |
1,132,000 |
0.19% |
|
|
| 34 |
TD ASSET MANAGEMENT INC |
31,200 |
1,076,000 |
0.18% |
|
|
| 35 |
Granite Point Capital Management, L.P. |
28,800 |
994,000 |
0.17% |
|
|
| 36 |
BAKER BROS. ADVISORS LP |
28,765 |
992,000 |
0.17% |
|
|
| 37 |
Board of Trustees of The Leland Stanford Junior University |
27,154 |
937,000 |
0.16% |
|
|
| 38 |
TWO SIGMA INVESTMENTS, LP |
23,164 |
799,000 |
0.14% |
|
|
| 39 |
MORGAN STANLEY |
22,985 |
793,000 |
0.13% |
|
|
| 40 |
Absolute Return Capital, LLC |
22,462 |
775,000 |
0.13% |
|
|
| 41 |
Foresite Capital Management I, LLC |
20,892 |
721,000 |
0.12% |
|
|
| 42 |
BlackRock Investment Management, LLC |
20,406 |
704,000 |
0.12% |
|
|
| 43 |
SPHERA FUNDS MANAGEMENT LTD. |
20,000 |
690,000 |
0.12% |
|
|
| 44 |
State of New Jersey Common Pension Fund A |
18,000 |
621,000 |
0.11% |
|
|
| 45 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
17,135 |
592,000 |
0.10% |
|
|
| 46 |
Spark Investment Management LLC |
16,500 |
569,000 |
0.10% |
|
|
| 47 |
PDT Partners, LLC |
16,299 |
562,000 |
0.10% |
|
|
| 48 |
TFS CAPITAL LLC |
15,852 |
547,000 |
0.09% |
|
|
| 49 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
14,325 |
494,000 |
0.08% |
|
|
| 50 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
12,900 |
445,000 |
0.08% |
|
|
