| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,958,861 | 123,476,000 | 19.83% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,125,001 | 77,813,000 | 12.50% | ||
| 3 | OAK RIDGE INVESTMENTS LLC | 1,525,181 | 37,976,000 | 6.10% | ||
| 4 | Polaris Venture Management Co IV LLC | 1,480,060 | 36,853,000 | 5.92% | ||
| 5 | VANGUARD GROUP INC | 1,237,665 | 30,818,000 | 4.95% | ||
| 6 | BlackRock Fund Advisors | 981,351 | 24,436,000 | 3.92% | ||
| 7 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 919,055 | 22,884,000 | 3.67% | ||
| 8 | QVT Financial LP | 861,813 | 21,459,000 | 3.45% | ||
| 9 | JPMORGAN CHASE & CO | 680,737 | 16,951,000 | 2.72% | ||
| 10 | SECTORAL ASSET MANAGEMENT INC | 612,184 | 15,243,000 | 2.45% | ||
| 11 | AGTC Partners, L.P. | 530,919 | 13,220,000 | 2.12% | ||
| 12 | FRANKLIN RESOURCES INC | 527,877 | 13,144,000 | 2.11% | ||
| 13 | ALPS ADVISORS INC | 51,747 | 12,885,000 | 2.07% | ||
| 14 | BLACKROCK ADVISORS LLC | 509,489 | 12,687,000 | 2.04% | ||
| 15 | Granahan Investment Management, LLC | 490,436 | 12,212,000 | 1.96% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 462,710 | 11,521,000 | 1.85% | ||
| 17 | STATE STREET CORP | 334,854 | 8,335,000 | 1.34% | ||
| 18 | CITADEL ADVISORS LLC | 313,315 | 7,801,000 | 1.25% | ||
| 19 | PERCEPTIVE ADVISORS LLC | 276,036 | 6,873,000 | 1.10% | ||
| 20 | BROWN ADVISORY INC | 266,983 | 6,647,000 | 1.07% | ||
| 21 | NORTHERN TRUST CORP | 240,919 | 5,999,000 | 0.96% | ||
| 22 | CLOUGH CAPITAL PARTNERS L P | 210,597 | 5,244,000 | 0.84% | ||
| 23 | Cormorant Asset Management, LP | 200,000 | 4,980,000 | 0.80% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 199,744 | 4,973,000 | 0.80% | ||
| 25 | Foresite Capital Management II, LLC | 198,717 | 4,948,000 | 0.79% | ||
| 26 | Foresite Capital Management I, LLC | 162,070 | 4,036,000 | 0.65% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 149,900 | 3,733,000 | 0.60% | Put | |
| 28 | MILLENNIUM MANAGEMENT LLC | 148,693 | 3,702,000 | 0.59% | ||
| 29 | PUTNAM INVESTMENTS LLC | 125,472 | 3,124,000 | 0.50% | ||
| 30 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 120,897 | 3,010,000 | 0.48% | ||
| 31 | BlackRock Group LTD | 116,042 | 2,890,000 | 0.46% | ||
| 32 | Iguana Healthcare Management, LLC | 110,000 | 2,739,000 | 0.44% | ||
| 33 | BlackRock Investment Management, LLC | 104,324 | 2,598,000 | 0.42% | ||
| 34 | DEUTSCHE BANK AG\ | 102,595 | 2,553,000 | 0.41% | ||
| 35 | Candriam S.C.A. | 100,800 | 2,510,000 | 0.40% | ||
| 36 | SPHERA FUNDS MANAGEMENT LTD. | 100,000 | 2,490,000 | 0.40% | ||
| 37 | Pentwater Capital Management LP | 96,771 | 2,410,000 | 0.39% | ||
| 38 | Bank of New York Mellon Corp | 96,530 | 2,404,000 | 0.39% | ||
| 39 | PRINCIPAL FINANCIAL GROUP INC | 94,800 | 2,361,000 | 0.38% | ||
| 40 | TFS CAPITAL LLC | 90,957 | 2,265,000 | 0.36% | ||
| 41 | CREDIT SUISSE AG/ | 90,422 | 2,252,000 | 0.36% | ||
| 42 | EVENTIDE ASSET MANAGEMENT, LLC | 87,100 | 2,169,000 | 0.35% | ||
| 43 | LORD, ABBETT & CO. LLC | 78,425 | 1,953,000 | 0.31% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 76,092 | 1,895,000 | 0.30% | ||
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 71,333 | 1,776,000 | 0.29% | ||
| 46 | TD ASSET MANAGEMENT INC | 62,600 | 1,559,000 | 0.25% | ||
| 47 | PICTET ASSET MANAGEMENT LTD | 61,700 | 1,536,000 | 0.25% | ||
| 48 | TURNER INVESTMENTS LLC | 57,240 | 1,425,000 | 0.23% | ||
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 57,200 | 1,424,000 | 0.23% | Call | |
| 50 | Telemetry Investments, L.L.C. | 54,700 | 1,362,000 | 0.22% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
