| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,635,185 | 203,937,000 | 17.14% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,284,766 | 118,876,000 | 9.99% | ||
| 3 | VANGUARD GROUP INC | 1,684,253 | 60,954,000 | 5.12% | ||
| 4 | Polaris Venture Management Co IV LLC | 1,480,060 | 53,563,000 | 4.50% | ||
| 5 | OAK RIDGE INVESTMENTS LLC | 1,226,468 | 44,386,000 | 3.73% | ||
| 6 | BlackRock Fund Advisors | 1,197,052 | 43,321,000 | 3.64% | ||
| 7 | Novo Holdings A/S | 903,833 | 32,710,000 | 2.75% | ||
| 8 | STATE STREET CORP | 886,955 | 32,098,000 | 2.70% | ||
| 9 | GOLDMAN SACHS GROUP INC | 835,383 | 30,233,000 | 2.54% | ||
| 10 | Granahan Investment Management, LLC | 817,149 | 29,573,000 | 2.48% | ||
| 11 | MORGAN STANLEY | 811,749 | 29,378,000 | 2.47% | ||
| 12 | EAGLE ASSET MANAGEMENT INC | 806,975 | 29,204,000 | 2.45% | ||
| 13 | JPMORGAN CHASE & CO | 801,745 | 29,015,000 | 2.44% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 757,640 | 27,419,000 | 2.30% | ||
| 15 | Laurion Capital Management LP | 690,000 | 24,971,000 | 2.10% | ||
| 16 | BLACKROCK ADVISORS LLC | 652,195 | 23,603,000 | 1.98% | ||
| 17 | QVT Financial LP | 636,764 | 23,044,000 | 1.94% | ||
| 18 | PERCEPTIVE ADVISORS LLC | 589,890 | 21,348,000 | 1.79% | ||
| 19 | FRANKLIN RESOURCES INC | 494,777 | 17,906,000 | 1.50% | ||
| 20 | SECTORAL ASSET MANAGEMENT INC | 481,765 | 17,435,000 | 1.46% | ||
| 21 | WESTFIELD CAPITAL MANAGEMENT CO LP | 479,885 | 17,367,000 | 1.46% | ||
| 22 | PICTET ASSET MANAGEMENT LTD | 470,106 | 17,013,000 | 1.43% | ||
| 23 | EVENTIDE ASSET MANAGEMENT, LLC | 428,900 | 15,522,000 | 1.30% | ||
| 24 | BROWN ADVISORY INC | 323,772 | 11,717,000 | 0.98% | ||
| 25 | DEUTSCHE BANK AG\ | 319,033 | 11,543,000 | 0.97% | ||
| 26 | RA CAPITAL MANAGEMENT, L.P. | 318,565 | 11,529,000 | 0.97% | ||
| 27 | NORTHERN TRUST CORP | 313,796 | 11,356,000 | 0.95% | ||
| 28 | CITADEL ADVISORS LLC | 310,573 | 11,240,000 | 0.94% | ||
| 29 | NORGES BANK | 322,652 | 11,153,000 | 0.94% | ||
| 30 | HILLHOUSE INVESTMENT MANAGEMENT, LTD. | 300,000 | 10,857,000 | 0.91% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 260,382 | 9,423,000 | 0.79% | ||
| 32 | MILLENNIUM MANAGEMENT LLC | 224,314 | 8,118,000 | 0.68% | ||
| 33 | NEXTHERA CAPITAL LP | 217,817 | 7,883,000 | 0.66% | ||
| 34 | CREDIT SUISSE AG/ | 206,619 | 7,478,000 | 0.63% | ||
| 35 | BlackRock Group LTD | 188,731 | 6,830,000 | 0.57% | ||
| 36 | Artal Group S.A. | 175,000 | 6,333,000 | 0.53% | ||
| 37 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 169,500 | 6,134,000 | 0.52% | ||
| 38 | LORD, ABBETT & CO. LLC | 163,045 | 5,901,000 | 0.50% | ||
| 39 | PUTNAM INVESTMENTS LLC | 139,053 | 5,033,000 | 0.42% | ||
| 40 | BlackRock Investment Management, LLC | 134,664 | 4,873,000 | 0.41% | ||
| 41 | Century Capital Management, LLC | 132,712 | 4,803,000 | 0.40% | ||
| 42 | Bank of New York Mellon Corp | 131,861 | 4,772,000 | 0.40% | ||
| 43 | Cormorant Asset Management, LP | 127,451 | 4,612,000 | 0.39% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 117,797 | 4,264,000 | 0.36% | ||
| 45 | PRINCIPAL FINANCIAL GROUP INC | 103,090 | 3,731,000 | 0.31% | ||
| 46 | VERDE SERVICOS INTERNACIONAIS S.A. | 108,632 | 3,691,000 | 0.31% | ||
| 47 | Candriam S.C.A. | 94,000 | 3,402,000 | 0.29% | ||
| 48 | OXFORD ASSET MANAGEMENT LLP | 92,215 | 3,337,000 | 0.28% | ||
| 49 | TIAA CREF INVESTMENT MANAGEMENT LLC | 83,696 | 3,029,000 | 0.25% | ||
| 50 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 79,080 | 2,862,000 | 0.24% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
