| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,837,978 | 188,488,000 | 19.46% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,411,375 | 132,907,000 | 13.72% | ||
| 3 | Polaris Venture Management Co IV LLC | 2,580,291 | 100,528,000 | 10.38% | ||
| 4 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,772,406 | 69,053,000 | 7.13% | ||
| 5 | QVT Financial LP | 962,217 | 37,488,000 | 3.87% | ||
| 6 | BlackRock Fund Advisors | 791,349 | 30,831,000 | 3.18% | ||
| 7 | VANGUARD GROUP INC | 774,869 | 30,189,000 | 3.12% | ||
| 8 | SECTORAL ASSET MANAGEMENT INC | 713,995 | 27,817,000 | 2.87% | ||
| 9 | OAK RIDGE INVESTMENTS LLC | 684,936 | 26,685,000 | 2.76% | ||
| 10 | JPMORGAN CHASE & CO | 665,547 | 25,931,000 | 2.68% | ||
| 11 | AGTC Partners, L.P. | 530,919 | 20,685,000 | 2.14% | ||
| 12 | FRANKLIN RESOURCES INC | 524,277 | 20,426,000 | 2.11% | ||
| 13 | BLACKROCK ADVISORS LLC | 441,625 | 17,205,000 | 1.78% | ||
| 14 | CLOUGH CAPITAL PARTNERS L P | 414,597 | 16,153,000 | 1.67% | ||
| 15 | CITADEL ADVISORS LLC | 392,668 | 15,298,000 | 1.58% | ||
| 16 | LOOMIS SAYLES & CO L P | 381,805 | 14,875,000 | 1.54% | ||
| 17 | PERCEPTIVE ADVISORS LLC | 317,636 | 12,375,000 | 1.28% | ||
| 18 | Granahan Investment Management, LLC | 305,988 | 11,921,000 | 1.23% | ||
| 19 | Cormorant Asset Management, LP | 250,000 | 9,740,000 | 1.01% | ||
| 20 | LORD, ABBETT & CO. LLC | 245,902 | 9,580,000 | 0.99% | ||
| 21 | STATE STREET CORP | 234,277 | 9,128,000 | 0.94% | ||
| 22 | Iguana Healthcare Management, LLC | 215,000 | 8,376,000 | 0.86% | ||
| 23 | BlackRock Institutional Trust Company, N.A. | 206,920 | 8,062,000 | 0.83% | ||
| 24 | DRIEHAUS CAPITAL MANAGEMENT LLC | 196,387 | 7,651,000 | 0.79% | ||
| 25 | NORTHERN TRUST CORP | 164,793 | 6,420,000 | 0.66% | ||
| 26 | BROWN ADVISORY INC | 161,940 | 6,309,000 | 0.65% | ||
| 27 | PICTET ASSET MANAGEMENT LTD | 116,204 | 4,527,000 | 0.47% | ||
| 28 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 113,400 | 4,418,000 | 0.46% | ||
| 29 | CREDIT SUISSE AG/ | 100,243 | 3,907,000 | 0.40% | ||
| 30 | BlackRock Group LTD | 89,301 | 3,479,000 | 0.36% | ||
| 31 | DEUTSCHE BANK AG\ | 86,661 | 3,374,000 | 0.35% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 84,500 | 3,292,000 | 0.34% | Call | |
| 33 | WALL STREET ASSOCIATES | 82,700 | 3,222,000 | 0.33% | ||
| 34 | Pentwater Capital Management LP | 80,000 | 3,117,000 | 0.32% | ||
| 35 | BlackRock Investment Management, LLC | 71,103 | 2,770,000 | 0.29% | ||
| 36 | Bank of New York Mellon Corp | 70,021 | 2,729,000 | 0.28% | ||
| 37 | TEACHERS ADVISORS, LLC | 69,597 | 2,711,000 | 0.28% | ||
| 38 | GEODE CAPITAL MANAGEMENT, LLC | 67,351 | 2,623,000 | 0.27% | ||
| 39 | EVENTIDE ASSET MANAGEMENT, LLC | 62,100 | 2,419,000 | 0.25% | ||
| 40 | ALLIANCEBERNSTEIN L.P. | 60,890 | 2,372,000 | 0.24% | ||
| 41 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 60,800 | 2,368,000 | 0.24% | Call | |
| 42 | TIAA CREF INVESTMENT MANAGEMENT LLC | 57,406 | 2,237,000 | 0.23% | ||
| 43 | TD ASSET MANAGEMENT INC | 56,900 | 2,217,000 | 0.23% | ||
| 44 | Foresite Capital Management I, LLC | 55,767 | 2,173,000 | 0.22% | ||
| 45 | Candriam S.C.A. | 55,000 | 2,143,000 | 0.22% | ||
| 46 | Jefferies Group LLC | 54,800 | 2,135,000 | 0.22% | Call | |
| 47 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 51,800 | 2,018,000 | 0.21% | Put | |
| 48 | HARBOURVEST PARTNERS LLC | 51,163 | 1,993,000 | 0.21% | ||
| 49 | HIGHLAND CAPITAL MANAGEMENT LP | 49,800 | 1,940,000 | 0.20% | ||
| 50 | Jefferies Group LLC | 49,700 | 1,936,000 | 0.20% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
