| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,921,795 | 155,726,000 | 19.72% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,147,643 | 99,591,000 | 12.61% | ||
| 3 | Polaris Venture Management Co IV LLC | 1,887,319 | 59,715,000 | 7.56% | ||
| 4 | OAK RIDGE INVESTMENTS LLC | 1,405,239 | 44,462,000 | 5.63% | ||
| 5 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,175,000 | 37,177,000 | 4.71% | ||
| 6 | BlackRock Fund Advisors | 940,872 | 29,769,000 | 3.77% | ||
| 7 | VANGUARD GROUP INC | 863,497 | 27,322,000 | 3.46% | ||
| 8 | QVT Financial LP | 775,249 | 24,529,000 | 3.11% | ||
| 9 | JPMORGAN CHASE & CO | 687,071 | 21,739,000 | 2.75% | ||
| 10 | SECTORAL ASSET MANAGEMENT INC | 652,084 | 20,632,000 | 2.61% | ||
| 11 | CLOUGH CAPITAL PARTNERS L P | 546,650 | 17,296,000 | 2.19% | ||
| 12 | FRANKLIN RESOURCES INC | 534,577 | 16,914,000 | 2.14% | ||
| 13 | AGTC Partners, L.P. | 530,919 | 16,798,000 | 2.13% | ||
| 14 | BLACKROCK ADVISORS LLC | 496,517 | 15,710,000 | 1.99% | ||
| 15 | Granahan Investment Management, LLC | 469,036 | 14,840,000 | 1.88% | ||
| 16 | CITADEL ADVISORS LLC | 387,438 | 12,259,000 | 1.55% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 312,530 | 9,888,000 | 1.25% | ||
| 18 | STATE STREET CORP | 283,638 | 8,973,000 | 1.14% | ||
| 19 | PERCEPTIVE ADVISORS LLC | 276,036 | 8,734,000 | 1.11% | ||
| 20 | BROWN ADVISORY INC | 249,181 | 7,884,000 | 1.00% | ||
| 21 | Pentwater Capital Management LP | 212,000 | 6,708,000 | 0.85% | ||
| 22 | Cormorant Asset Management, LP | 200,000 | 6,328,000 | 0.80% | ||
| 23 | NORTHERN TRUST CORP | 174,614 | 5,524,000 | 0.70% | ||
| 24 | LORD, ABBETT & CO. LLC | 163,697 | 5,180,000 | 0.66% | ||
| 25 | Foresite Capital Management I, LLC | 162,070 | 5,128,000 | 0.65% | ||
| 26 | Iguana Healthcare Management, LLC | 150,000 | 4,746,000 | 0.60% | ||
| 27 | PUTNAM INVESTMENTS LLC | 125,472 | 3,970,000 | 0.50% | ||
| 28 | TFS CAPITAL LLC | 118,728 | 3,757,000 | 0.48% | ||
| 29 | CREDIT SUISSE AG/ | 117,795 | 3,727,000 | 0.47% | ||
| 30 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 115,792 | 3,663,000 | 0.46% | ||
| 31 | DEUTSCHE BANK AG\ | 115,116 | 3,641,000 | 0.46% | ||
| 32 | BlackRock Group LTD | 110,328 | 3,491,000 | 0.44% | ||
| 33 | ALLIANCEBERNSTEIN L.P. | 106,240 | 3,361,000 | 0.43% | ||
| 34 | BlackRock Investment Management, LLC | 104,163 | 3,296,000 | 0.42% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 102,800 | 3,253,000 | 0.41% | Put | |
| 36 | Candriam S.C.A. | 100,000 | 3,164,000 | 0.40% | ||
| 37 | SPHERA FUNDS MANAGEMENT LTD. | 100,000 | 3,164,000 | 0.40% | ||
| 38 | PRINCIPAL FINANCIAL GROUP INC | 94,400 | 2,987,000 | 0.38% | ||
| 39 | Bank of New York Mellon Corp | 93,359 | 2,954,000 | 0.37% | ||
| 40 | EVENTIDE ASSET MANAGEMENT, LLC | 87,100 | 2,756,000 | 0.35% | ||
| 41 | TEACHERS ADVISORS, LLC | 78,040 | 2,469,000 | 0.31% | ||
| 42 | GEODE CAPITAL MANAGEMENT, LLC | 77,600 | 2,455,000 | 0.31% | ||
| 43 | WALL STREET ASSOCIATES | 76,000 | 2,405,000 | 0.30% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 73,059 | 2,312,000 | 0.29% | ||
| 45 | MILLENNIUM MANAGEMENT LLC | 71,865 | 2,274,000 | 0.29% | ||
| 46 | RENAISSANCE TECHNOLOGIES LLC | 64,300 | 2,034,000 | 0.26% | ||
| 47 | TD ASSET MANAGEMENT INC | 61,900 | 1,959,000 | 0.25% | ||
| 48 | TURNER INVESTMENTS LLC | 57,740 | 1,827,000 | 0.23% | ||
| 49 | Telemetry Investments, L.L.C. | 54,000 | 1,709,000 | 0.22% | ||
| 50 | HIGHLAND CAPITAL MANAGEMENT LP | 53,500 | 1,693,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
