| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,560,161 | 146,733,000 | 18.79% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,947,139 | 77,775,000 | 9.96% | ||
| 3 | OAK RIDGE INVESTMENTS LLC | 1,505,649 | 39,734,000 | 5.09% | ||
| 4 | Polaris Venture Management Co IV LLC | 1,480,060 | 39,059,000 | 5.00% | ||
| 5 | VANGUARD GROUP INC | 1,464,859 | 38,659,000 | 4.95% | ||
| 6 | SECTORAL ASSET MANAGEMENT INC | 1,437,235 | 37,929,000 | 4.86% | ||
| 7 | BlackRock Fund Advisors | 1,070,110 | 28,240,000 | 3.62% | ||
| 8 | STATE STREET CORP | 853,062 | 22,514,000 | 2.88% | ||
| 9 | PERCEPTIVE ADVISORS LLC | 803,036 | 21,192,000 | 2.71% | ||
| 10 | JPMORGAN CHASE & CO | 793,834 | 20,949,000 | 2.68% | ||
| 11 | EAGLE ASSET MANAGEMENT INC | 776,456 | 20,490,000 | 2.62% | ||
| 12 | Granahan Investment Management, LLC | 722,469 | 19,066,000 | 2.44% | ||
| 13 | QVT Financial LP | 702,410 | 18,537,000 | 2.37% | ||
| 14 | BLACKROCK ADVISORS LLC | 675,209 | 17,819,000 | 2.28% | ||
| 15 | Novo Holdings A/S | 673,063 | 17,762,000 | 2.27% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 646,645 | 17,065,000 | 2.19% | ||
| 17 | FRANKLIN RESOURCES INC | 494,777 | 13,057,000 | 1.67% | ||
| 18 | EVENTIDE ASSET MANAGEMENT, LLC | 423,500 | 11,176,000 | 1.43% | ||
| 19 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 387,500 | 10,226,000 | 1.31% | ||
| 20 | DEERFIELD MANAGEMENT COMPANY, L.P. | 353,491 | 9,329,000 | 1.19% | ||
| 21 | DEUTSCHE BANK AG\ | 310,622 | 8,195,000 | 1.05% | ||
| 22 | NORTHERN TRUST CORP | 288,289 | 7,607,000 | 0.97% | ||
| 23 | BROWN ADVISORY INC | 284,188 | 7,501,000 | 0.96% | ||
| 24 | EcoR1 Capital, LLC | 270,289 | 7,133,000 | 0.91% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 237,228 | 6,260,000 | 0.80% | ||
| 26 | GOLDMAN SACHS GROUP INC | 217,327 | 5,735,000 | 0.73% | ||
| 27 | Cormorant Asset Management, LP | 200,000 | 5,278,000 | 0.68% | ||
| 28 | GOLDMAN SACHS GROUP INC | 195,000 | 5,146,000 | 0.66% | Put | |
| 29 | BlackRock Group LTD | 191,173 | 5,045,000 | 0.65% | ||
| 30 | Foresite Capital Management II, LLC | 174,089 | 4,594,000 | 0.59% | ||
| 31 | CREDIT SUISSE AG/ | 140,878 | 3,720,000 | 0.48% | ||
| 32 | Bank of New York Mellon Corp | 131,723 | 3,478,000 | 0.45% | ||
| 33 | VERDE SERVICOS INTERNACIONAIS S.A. | 126,726 | 3,344,000 | 0.43% | ||
| 34 | LORD, ABBETT & CO. LLC | 125,464 | 3,311,000 | 0.42% | ||
| 35 | PUTNAM INVESTMENTS LLC | 125,000 | 3,299,000 | 0.42% | ||
| 36 | BlackRock Investment Management, LLC | 117,762 | 3,108,000 | 0.40% | ||
| 37 | Candriam S.C.A. | 115,000 | 3,018,000 | 0.39% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 106,423 | 2,809,000 | 0.36% | ||
| 39 | PRINCIPAL FINANCIAL GROUP INC | 99,600 | 2,628,000 | 0.34% | ||
| 40 | FORESITE CAPITAL MANAGEMENT III, LLC | 94,403 | 2,491,000 | 0.32% | ||
| 41 | TFS CAPITAL LLC | 91,943 | 2,426,000 | 0.31% | ||
| 42 | PRUDENTIAL FINANCIAL INC | 90,200 | 2,380,000 | 0.30% | ||
| 43 | TIAA CREF INVESTMENT MANAGEMENT LLC | 89,587 | 2,364,000 | 0.30% | ||
| 44 | MORGAN STANLEY | 86,107 | 2,273,000 | 0.29% | ||
| 45 | PICTET ASSET MANAGEMENT LTD | 86,100 | 2,182,000 | 0.28% | ||
| 46 | Iguana Healthcare Management, LLC | 75,000 | 1,979,000 | 0.25% | ||
| 47 | CLOUGH CAPITAL PARTNERS L P | 67,997 | 1,794,000 | 0.23% | ||
| 48 | TD ASSET MANAGEMENT INC | 61,100 | 1,612,000 | 0.21% | ||
| 49 | Alyeska Investment Group, L.P. | 60,000 | 1,583,000 | 0.20% | ||
| 50 | PDT Partners, LLC | 58,465 | 1,543,000 | 0.20% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
