| # | % | |||||
|---|---|---|---|---|---|---|
| 101 | DIMENSIONAL FUND ADVISORS LP | 36,774 | 4,120,000 | 0.13% | ||
| 102 | WILLIAMS JONES & ASSOCIATES LLC | 37,685 | 4,222,000 | 0.13% | ||
| 103 | CADENCE CAPITAL MANAGEMENT LLC | 39,020 | 4,372,000 | 0.14% | ||
| 104 | Crosspoint Capital Strategies, LLC | 39,770 | 4,456,000 | 0.14% | ||
| 105 | CREDIT SUISSE AG/ | 39,947 | 4,474,000 | 0.14% | ||
| 106 | Tekla Capital Management LLC | 46,200 | 5,176,000 | 0.16% | ||
| 107 | TIAA CREF INVESTMENT MANAGEMENT LLC | 48,151 | 5,395,000 | 0.17% | ||
| 108 | A.R.T. Advisors, LLC | 55,377 | 6,204,000 | 0.20% | ||
| 109 | QVT Financial LP | 56,048 | 6,280,000 | 0.20% | ||
| 110 | BlackRock Investment Management, LLC | 62,710 | 7,026,000 | 0.22% | ||
| 111 | Capital International, Inc./CA/ | 66,600 | 7,462,000 | 0.24% | ||
| 112 | AXA S.A. | 66,603 | 7,462,000 | 0.24% | ||
| 113 | GEODE CAPITAL MANAGEMENT, LLC | 70,502 | 7,899,000 | 0.25% | ||
| 114 | GUGGENHEIM CAPITAL LLC | 71,647 | 8,027,000 | 0.25% | ||
| 115 | Bank of New York Mellon Corp | 81,037 | 9,079,000 | 0.29% | ||
| 116 | BlackRock Group LTD | 87,757 | 9,832,000 | 0.31% | ||
| 117 | Capital International Sarl | 89,300 | 10,005,000 | 0.32% | ||
| 118 | Artal Group S.A. | 90,000 | 10,084,000 | 0.32% | ||
| 119 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 98,747 | 11,064,000 | 0.35% | ||
| 120 | Artisan Partners Limited Partnership | 99,573 | 11,156,000 | 0.35% | ||
| 121 | GILDER GAGNON HOWE & CO LLC | 103,316 | 11,576,000 | 0.37% | ||
| 122 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 107,300 | 12,022,000 | 0.38% | Call | |
| 123 | PRICE T ROWE ASSOCIATES INC /MD/ | 107,580 | 12,053,000 | 0.38% | ||
| 124 | Opaleye Management Inc. | 113,500 | 12,717,000 | 0.40% | ||
| 125 | COLUMBUS CIRCLE INVESTORS | 122,547 | 13,730,000 | 0.43% | ||
| 126 | JANUS HENDERSON INVESTORS US LLC | 131,520 | 14,736,000 | 0.47% | ||
| 127 | CAPITAL INTERNATIONAL LTD /CA/ | 138,200 | 15,484,000 | 0.49% | ||
| 128 | UBS Group AG | 148,464 | 16,634,000 | 0.53% | ||
| 129 | JENNISON ASSOCIATES LLC | 156,277 | 17,509,000 | 0.55% | ||
| 130 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 158,100 | 17,714,000 | 0.56% | Put | |
| 131 | BAKER BROS. ADVISORS LP | 163,393 | 18,307,000 | 0.58% | ||
| 132 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 164,500 | 18,431,000 | 0.58% | ||
| 133 | NORTHERN TRUST CORP | 164,820 | 18,466,000 | 0.58% | ||
| 134 | DEUTSCHE BANK AG\ | 174,752 | 19,576,000 | 0.62% | ||
| 135 | JPMORGAN CHASE & CO | 189,820 | 21,267,000 | 0.67% | ||
| 136 | FEDERATED HERMES, INC. | 191,700 | 21,478,000 | 0.68% | ||
| 137 | MORGAN STANLEY | 231,236 | 25,908,000 | 0.82% | ||
| 138 | ALLIANCEBERNSTEIN L.P. | 252,214 | 28,258,000 | 0.89% | ||
| 139 | EVENTIDE ASSET MANAGEMENT, LLC | 258,200 | 28,929,000 | 0.92% | ||
| 140 | Clearbridge Investments, LLC | 276,030 | 30,926,000 | 0.98% | ||
| 141 | BlackRock Institutional Trust Company, N.A. | 287,122 | 32,169,000 | 1.02% | ||
| 142 | LORD, ABBETT & CO. LLC | 301,517 | 33,782,000 | 1.07% | ||
| 143 | STATE STREET CORP | 373,383 | 41,830,000 | 1.32% | ||
| 144 | BLACKROCK ADVISORS LLC | 382,619 | 42,868,000 | 1.36% | ||
| 145 | CAPITAL GUARDIAN TRUST CO | 686,575 | 79,588,000 | 2.52% | ||
| 146 | BlackRock Fund Advisors | 785,222 | 87,976,000 | 2.78% | ||
| 147 | Capital International Investors | 856,400 | 95,951,000 | 3.04% | ||
| 148 | VANGUARD GROUP INC | 1,291,702 | 144,722,000 | 4.58% | ||
| 149 | BB BIOTECH AG | 1,864,921 | 208,946,000 | 6.61% | ||
| 150 | Flagship Ventures 2007 General Partner LLC | 1,930,369 | 216,278,000 | 6.84% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
