| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,331,747 | 369,774,000 | 15.27% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 5,893,596 | 344,186,000 | 14.21% | ||
| 3 | BB BIOTECH AG | 2,839,528 | 165,828,000 | 6.85% | ||
| 4 | Capital International Investors | 2,804,527 | 163,784,000 | 6.76% | ||
| 5 | VANGUARD GROUP INC | 2,597,391 | 151,688,000 | 6.26% | ||
| 6 | BlackRock Finance, Inc. | 2,167,074 | 126,556,000 | 5.23% | ||
| 7 | Clearbridge Investments, LLC | 1,538,912 | 89,872,000 | 3.71% | ||
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,402,174 | 81,887,000 | 3.38% | ||
| 9 | STATE STREET CORP | 1,205,746 | 70,417,000 | 2.91% | ||
| 10 | FLAGSHIP VENTURES MANAGEMENT, INC. | 965,369 | 56,378,000 | 2.33% | ||
| 11 | CAPITAL GUARDIAN TRUST CO | 934,879 | 54,597,000 | 2.25% | ||
| 12 | Redmile Group, LLC | 902,578 | 52,711,000 | 2.18% | ||
| 13 | BALYASNY ASSET MANAGEMENT L.P. | 869,122 | 50,757,000 | 2.10% | ||
| 14 | Artal Group S.A. | 750,000 | 43,800,000 | 1.81% | ||
| 15 | Capital World Investors | 663,000 | 38,719,000 | 1.60% | ||
| 16 | GOLDMAN SACHS GROUP INC | 649,124 | 37,909,000 | 1.57% | ||
| 17 | FIRST TRUST ADVISORS LP | 639,579 | 37,351,000 | 1.54% | ||
| 18 | NORGES BANK | 628,027 | 36,676,000 | 1.51% | ||
| 19 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 610,086 | 35,629,000 | 1.47% | ||
| 20 | JANUS HENDERSON INVESTORS US LLC | 375,084 | 21,904,000 | 0.90% | ||
| 21 | CAPITAL INTERNATIONAL LTD /CA/ | 346,937 | 20,261,000 | 0.84% | ||
| 22 | Invesco Ltd. | 321,030 | 18,748,000 | 0.77% | ||
| 23 | EVENTIDE ASSET MANAGEMENT, LLC | 300,800 | 17,567,000 | 0.73% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 263,899 | 15,410,000 | 0.64% | ||
| 25 | BROWN ADVISORY INC | 263,542 | 15,391,000 | 0.64% | ||
| 26 | CASDIN CAPITAL, LLC | 237,500 | 13,870,000 | 0.57% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 217,700 | 12,714,000 | 0.53% | Put | |
| 28 | NORTHERN TRUST CORP | 177,242 | 10,350,000 | 0.43% | ||
| 29 | CREDIT SUISSE AG/ | 172,465 | 10,072,000 | 0.42% | ||
| 30 | JENNISON ASSOCIATES LLC | 169,799 | 9,916,000 | 0.41% | ||
| 31 | DEUTSCHE BANK AG\ | 166,080 | 9,696,000 | 0.40% | ||
| 32 | BNP Paribas Asset Management Holding S.A. | 159,970 | 9,342,000 | 0.39% | ||
| 33 | Capital International Sarl | 153,100 | 8,941,000 | 0.37% | ||
| 34 | LORD, ABBETT & CO. LLC | 147,074 | 8,589,000 | 0.35% | ||
| 35 | Opaleye Management Inc. | 130,000 | 7,592,000 | 0.31% | ||
| 36 | BAKER BROS. ADVISORS LP | 128,666 | 7,514,000 | 0.31% | ||
| 37 | Bank of New York Mellon Corp | 126,715 | 7,400,000 | 0.31% | ||
| 38 | ArrowMark Colorado Holdings LLC | 126,062 | 7,362,000 | 0.30% | ||
| 39 | Ghost Tree Capital, LLC | 125,000 | 7,300,000 | 0.30% | ||
| 40 | Hood River Capital Management LLC | 116,218 | 6,787,000 | 0.28% | ||
| 41 | CLARIUS GROUP, LLC | 109,230 | 6,379,000 | 0.26% | ||
| 42 | Artal Group S.A. | 100,000 | 5,840,000 | 0.24% | Call | |
| 43 | TIAA CREF INVESTMENT MANAGEMENT LLC | 89,235 | 5,211,000 | 0.22% | ||
| 44 | CAPITAL FUND MANAGEMENT S.A. | 88,185 | 5,150,000 | 0.21% | ||
| 45 | Capital International, Inc./CA/ | 85,800 | 5,011,000 | 0.21% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 83,327 | 4,867,000 | 0.20% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 83,100 | 4,853,000 | 0.20% | Call | |
| 48 | BARCLAYS PLC | 79,261 | 4,629,000 | 0.19% | ||
| 49 | NEW YORK STATE COMMON RETIREMENT FUND | 73,191 | 4,274,000 | 0.18% | ||
| 50 | Quantitative Investment Management, LLC | 71,100 | 4,152,000 | 0.17% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
