| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,436,363 | 55,646,000 | 15.51% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,227,561 | 28,037,000 | 7.82% | ||
| 3 | Aisling Capital LLC | 1,222,943 | 27,900,000 | 7.78% | ||
| 4 | JPMORGAN CHASE & CO | 1,085,938 | 24,803,000 | 6.92% | ||
| 5 | Redmile Group, LLC | 895,006 | 20,442,000 | 5.70% | ||
| 6 | Canaan Partners VII LLC | 861,664 | 19,680,000 | 5.49% | ||
| 7 | JANUS HENDERSON INVESTORS US LLC | 842,862 | 19,251,000 | 5.37% | ||
| 8 | SAC Capital Advisors LP | 662,960 | 15,142,000 | 4.22% | ||
| 9 | JENNISON ASSOCIATES LLC | 661,287 | 15,104,000 | 4.21% | ||
| 10 | BlackRock Fund Advisors | 560,620 | 12,805,000 | 3.57% | ||
| 11 | Opaleye Management Inc. | 536,000 | 12,242,000 | 3.41% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 497,523 | 11,363,000 | 3.17% | ||
| 13 | VANGUARD GROUP INC | 449,188 | 10,259,000 | 2.86% | ||
| 14 | EVENTIDE ASSET MANAGEMENT, LLC | 411,900 | 9,408,000 | 2.62% | ||
| 15 | Cormorant Asset Management, LP | 300,000 | 6,852,000 | 1.91% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 286,097 | 6,534,000 | 1.82% | ||
| 17 | MORGAN STANLEY | 155,191 | 3,545,000 | 0.99% | ||
| 18 | PERCEPTIVE ADVISORS LLC | 140,000 | 3,199,000 | 0.89% | ||
| 19 | TWO SIGMA INVESTMENTS, LP | 139,144 | 3,178,000 | 0.89% | ||
| 20 | CITADEL ADVISORS LLC | 138,786 | 3,170,000 | 0.88% | ||
| 21 | STATE STREET CORP | 117,542 | 2,686,000 | 0.75% | ||
| 22 | NORTHERN TRUST CORP | 117,450 | 2,682,000 | 0.75% | ||
| 23 | Bank of New York Mellon Corp | 110,532 | 2,525,000 | 0.70% | ||
| 24 | PUTNAM INVESTMENTS LLC | 100,300 | 2,291,000 | 0.64% | ||
| 25 | CI INVESTMENTS INC. | 98,000 | 2,238,000 | 0.62% | ||
| 26 | Informed Momentum Co LLC | 96,035 | 2,193,000 | 0.61% | ||
| 27 | Nicholas Investment Partners, LP | 92,636 | 2,115,000 | 0.59% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 81,257 | 1,855,000 | 0.52% | ||
| 29 | MARSHALL WACE, LLP | 74,227 | 1,695,000 | 0.47% | ||
| 30 | HIGHLAND CAPITAL MANAGEMENT LP | 70,191 | 1,603,000 | 0.45% | ||
| 31 | WELLINGTON MANAGEMENT GROUP LLP | 68,066 | 1,555,000 | 0.43% | ||
| 32 | HAMILTON LANE ADVISORS LLC | 65,900 | 1,505,000 | 0.42% | ||
| 33 | Biondo Investment Advisors, LLC | 63,675 | 1,454,000 | 0.41% | ||
| 34 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 61,790 | 1,411,000 | 0.39% | ||
| 35 | Tourbillon Capital Partners, L.P. | 59,209 | 1,352,000 | 0.38% | ||
| 36 | RUSSELL FRANK CO/ | 62,230 | 1,198,000 | 0.33% | ||
| 37 | STATE OF MICHIGAN RETIREMENT SYSTEM | 49,133 | 1,122,000 | 0.31% | ||
| 38 | AMERIPRISE FINANCIAL INC | 46,260 | 1,057,000 | 0.29% | ||
| 39 | TWO SIGMA ADVISERS, LP | 44,000 | 1,005,000 | 0.28% | ||
| 40 | ONTARIO TEACHERS PENSION PLAN BOARD | 42,541 | 972,000 | 0.27% | ||
| 41 | DSC Advisors, L.P. | 40,000 | 914,000 | 0.25% | ||
| 42 | Weiss Multi-Strategy Advisers LLC | 40,000 | 914,000 | 0.25% | ||
| 43 | BLACKROCK ADVISORS LLC | 39,896 | 911,000 | 0.25% | ||
| 44 | AXA S.A. | 36,380 | 831,000 | 0.23% | ||
| 45 | DUPONT CAPITAL MANAGEMENT CORP | 31,111 | 798,000 | 0.22% | ||
| 46 | TIAA CREF INVESTMENT MANAGEMENT LLC | 33,222 | 759,000 | 0.21% | ||
| 47 | ProShare Advisors LLC | 28,825 | 658,000 | 0.18% | ||
| 48 | NORTHWESTERN MUTUAL LIFE INSURANCE CO | 28,359 | 648,000 | 0.18% | ||
| 49 | MASON STREET ADVISORS, LLC | 28,359 | 632,000 | 0.18% | ||
| 50 | BlackRock Investment Management, LLC | 23,690 | 541,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
