| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,350,417 | 147,779,000 | 18.53% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,440,517 | 67,407,000 | 8.45% | ||
| 3 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 2,091,658 | 57,771,000 | 7.24% | ||
| 4 | JANUS HENDERSON INVESTORS US LLC | 1,874,728 | 51,780,000 | 6.49% | ||
| 5 | Aisling Capital LLC | 1,522,943 | 42,060,000 | 5.27% | ||
| 6 | Redmile Group, LLC | 1,121,032 | 30,963,000 | 3.88% | ||
| 7 | BlackRock Fund Advisors | 1,079,190 | 29,807,000 | 3.74% | ||
| 8 | STATE STREET CORP | 936,698 | 25,868,000 | 3.24% | ||
| 9 | Point72 Asset Management, L.P. | 900,000 | 24,858,000 | 3.12% | ||
| 10 | VANGUARD GROUP INC | 874,800 | 24,161,000 | 3.03% | ||
| 11 | SECTORAL ASSET MANAGEMENT INC | 842,149 | 23,260,000 | 2.92% | ||
| 12 | JPMORGAN CHASE & CO | 788,741 | 21,784,000 | 2.73% | ||
| 13 | Opaleye Management Inc. | 755,000 | 20,853,100 | 2.61% | ||
| 14 | ORACLE INVESTMENT MANAGEMENT INC | 600,000 | 16,572,000 | 2.08% | ||
| 15 | LOOMIS SAYLES & CO L P | 577,724 | 15,957,000 | 2.00% | ||
| 16 | JENNISON ASSOCIATES LLC | 553,129 | 15,277,000 | 1.92% | ||
| 17 | RS INVESTMENT MANAGEMENT CO LLC | 510,900 | 14,111,000 | 1.77% | ||
| 18 | CITADEL ADVISORS LLC | 475,049 | 13,120,000 | 1.65% | ||
| 19 | EVENTIDE ASSET MANAGEMENT, LLC | 418,600 | 11,562,000 | 1.45% | ||
| 20 | DEERFIELD MANAGEMENT COMPANY, L.P. | 406,100 | 11,216,000 | 1.41% | ||
| 21 | EAGLE ASSET MANAGEMENT INC | 316,382 | 8,738,000 | 1.10% | ||
| 22 | NORTHERN TRUST CORP | 308,842 | 8,530,000 | 1.07% | ||
| 23 | BlackRock Institutional Trust Company, N.A. | 306,460 | 8,464,000 | 1.06% | ||
| 24 | AXA S.A. | 254,978 | 7,042,000 | 0.88% | ||
| 25 | Cormorant Asset Management, LP | 250,000 | 6,905,000 | 0.87% | ||
| 26 | Asset Management One Co., Ltd. | 199,325 | 5,752,000 | 0.72% | ||
| 27 | TURNER INVESTMENTS LLC | 199,060 | 5,498,000 | 0.69% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 171,988 | 4,750,000 | 0.60% | ||
| 29 | Bank of New York Mellon Corp | 162,090 | 4,477,000 | 0.56% | ||
| 30 | MILLENNIUM MANAGEMENT LLC | 143,382 | 3,960,000 | 0.50% | ||
| 31 | PERCEPTIVE ADVISORS LLC | 128,000 | 3,535,000 | 0.44% | ||
| 32 | MORGAN STANLEY | 123,770 | 3,419,000 | 0.43% | ||
| 33 | DEUTSCHE BANK AG\ | 116,613 | 3,220,000 | 0.40% | ||
| 34 | Biondo Investment Advisors, LLC | 115,075 | 3,178,000 | 0.40% | ||
| 35 | PUTNAM INVESTMENTS LLC | 99,700 | 2,754,000 | 0.35% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 95,855 | 2,648,000 | 0.33% | ||
| 37 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 94,600 | 2,613,000 | 0.33% | ||
| 38 | Ghost Tree Capital, LLC | 80,500 | 2,223,000 | 0.28% | ||
| 39 | EverPoint Asset Management, LLC | 80,000 | 2,210,000 | 0.28% | ||
| 40 | Nicholas Investment Partners, LP | 78,560 | 2,170,000 | 0.27% | ||
| 41 | BlackRock Investment Management, LLC | 78,434 | 2,166,000 | 0.27% | ||
| 42 | Iguana Healthcare Management, LLC | 75,000 | 2,072,000 | 0.26% | ||
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 71,618 | 1,979,000 | 0.25% | ||
| 44 | WELLINGTON MANAGEMENT GROUP LLP | 68,236 | 1,885,000 | 0.24% | ||
| 45 | PICTET ASSET MANAGEMENT LTD | 61,200 | 1,690,000 | 0.21% | ||
| 46 | PointState Capital LP | 50,000 | 1,381,000 | 0.17% | ||
| 47 | DSC Advisors, L.P. | 50,000 | 1,381,000 | 0.17% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 49,774 | 1,375,000 | 0.17% | ||
| 49 | Informed Momentum Co LLC | 47,588 | 1,314,000 | 0.16% | ||
| 50 | ALLIANCEBERNSTEIN L.P. | 41,700 | 1,152,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
