| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,928,334 | 38,383,000 | 20.63% | ||
| 2 | Redmile Group, LLC | 3,214,946 | 17,811,000 | 9.57% | ||
| 3 | Numeric Investors LLC | 1,991,074 | 11,031,000 | 5.93% | ||
| 4 | BlackRock Fund Advisors | 1,838,800 | 10,187,000 | 5.48% | ||
| 5 | VANGUARD GROUP INC | 1,511,726 | 8,375,000 | 4.50% | ||
| 6 | JENNISON ASSOCIATES LLC | 1,276,937 | 7,074,000 | 3.80% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 1,097,858 | 6,082,000 | 3.27% | ||
| 8 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 909,773 | 5,040,000 | 2.71% | ||
| 9 | ArrowMark Colorado Holdings LLC | 822,022 | 4,554,000 | 2.45% | ||
| 10 | Opaleye Management Inc. | 780,000 | 4,321,000 | 2.32% | ||
| 11 | STATE STREET CORP | 732,343 | 4,059,000 | 2.18% | ||
| 12 | EcoR1 Capital, LLC | 598,062 | 3,313,000 | 1.78% | ||
| 13 | FARALLON CAPITAL MANAGEMENT LLC | 593,138 | 3,286,000 | 1.77% | ||
| 14 | NORTHERN TRUST CORP | 592,137 | 3,281,000 | 1.76% | ||
| 15 | Rhenman & Partners Asset Management AB | 550,000 | 3,047,000 | 1.64% | ||
| 16 | JPMORGAN CHASE & CO | 545,574 | 3,022,000 | 1.62% | ||
| 17 | Artal Group S.A. | 500,000 | 2,770,000 | 1.49% | ||
| 18 | Aisling Capital LLC | 472,943 | 2,620,000 | 1.41% | ||
| 19 | D. E. Shaw & Co., Inc. | 459,500 | 2,545,000 | 1.37% | ||
| 20 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 443,152 | 2,455,000 | 1.32% | ||
| 21 | MORGAN STANLEY | 439,040 | 2,433,000 | 1.31% | ||
| 22 | GOLDMAN SACHS GROUP INC | 419,055 | 2,322,000 | 1.25% | ||
| 23 | Tekla Capital Management LLC | 308,892 | 1,711,000 | 0.92% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 295,461 | 1,636,000 | 0.88% | ||
| 25 | PANAGORA ASSET MANAGEMENT INC | 287,382 | 1,592,000 | 0.86% | ||
| 26 | PRUDENTIAL FINANCIAL INC | 276,040 | 1,530,000 | 0.82% | ||
| 27 | QS Investors, LLC | 260,916 | 1,445,000 | 0.78% | ||
| 28 | MILLENNIUM MANAGEMENT LLC | 246,067 | 1,363,000 | 0.73% | ||
| 29 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 240,773 | 1,334,000 | 0.72% | ||
| 30 | RENAISSANCE TECHNOLOGIES LLC | 218,860 | 1,212,000 | 0.65% | ||
| 31 | FT OPTIONS LLC | 205,266 | 1,137,000 | 0.61% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 196,450 | 1,088,000 | 0.58% | ||
| 33 | GSA CAPITAL PARTNERS LLP | 188,409 | 1,044,000 | 0.56% | ||
| 34 | BlackRock Investment Management, LLC | 187,449 | 1,038,000 | 0.56% | ||
| 35 | Bank of New York Mellon Corp | 178,069 | 987,000 | 0.53% | ||
| 36 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 173,888 | 963,000 | 0.52% | ||
| 37 | DEUTSCHE BANK AG\ | 170,166 | 941,000 | 0.51% | ||
| 38 | ACADIAN ASSET MANAGEMENT LLC | 166,366 | 922,000 | 0.50% | ||
| 39 | DIMENSIONAL FUND ADVISORS LP | 165,056 | 914,000 | 0.49% | ||
| 40 | PRICE T ROWE ASSOCIATES INC /MD/ | 160,298 | 888,000 | 0.48% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 153,900 | 853,000 | 0.46% | Call | |
| 42 | TWO SIGMA INVESTMENTS, LP | 147,401 | 817,000 | 0.44% | ||
| 43 | AQR CAPITAL MANAGEMENT LLC | 145,609 | 806,000 | 0.43% | ||
| 44 | AXA S.A. | 135,580 | 751,000 | 0.40% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 121,896 | 676,000 | 0.36% | ||
| 46 | CITADEL ADVISORS LLC | 116,575 | 646,000 | 0.35% | ||
| 47 | BAKER BROS. ADVISORS LP | 115,216 | 638,000 | 0.34% | ||
| 48 | SHELL ASSET MANAGEMENT CO | 112,516 | 623,000 | 0.33% | ||
| 49 | EAGLE GLOBAL ADVISORS LLC | 107,230 | 594,000 | 0.32% | ||
| 50 | LOS ANGELES CAPITAL MANAGEMENT LLC | 107,005 | 593,000 | 0.32% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
