| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,906,388 | 263,824,000 | 16.15% | ||
| 2 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 3,351,935 | 128,045,000 | 7.84% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,928,155 | 111,856,000 | 6.85% | ||
| 4 | VANGUARD GROUP INC | 2,820,960 | 107,760,000 | 6.60% | ||
| 5 | JANUS HENDERSON INVESTORS US LLC | 2,351,371 | 89,822,000 | 5.50% | ||
| 6 | BlackRock Fund Advisors | 1,771,639 | 67,677,000 | 4.14% | ||
| 7 | EAGLE ASSET MANAGEMENT INC | 1,187,183 | 45,350,000 | 2.78% | ||
| 8 | STATE STREET CORP | 1,186,354 | 45,316,000 | 2.77% | ||
| 9 | JPMORGAN CHASE & CO | 1,110,149 | 42,407,000 | 2.60% | ||
| 10 | Redmile Group, LLC | 1,067,978 | 40,797,000 | 2.50% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 1,039,708 | 39,717,000 | 2.43% | ||
| 12 | ORBIMED ADVISORS LLC | 1,021,600 | 39,025,000 | 2.39% | ||
| 13 | ORACLE INVESTMENT MANAGEMENT INC | 986,421 | 37,681,000 | 2.31% | ||
| 14 | RS INVESTMENT MANAGEMENT CO LLC | 778,093 | 29,723,000 | 1.82% | ||
| 15 | JENNISON ASSOCIATES LLC | 758,750 | 28,984,000 | 1.77% | ||
| 16 | Aisling Capital LLC | 722,943 | 27,616,000 | 1.69% | ||
| 17 | ALPS ADVISORS INC | 72,108 | 27,545,000 | 1.69% | ||
| 18 | OAK RIDGE INVESTMENTS LLC | 679,859 | 25,971,000 | 1.59% | ||
| 19 | LORD, ABBETT & CO. LLC | 573,660 | 21,914,000 | 1.34% | ||
| 20 | CITADEL ADVISORS LLC | 569,827 | 21,767,000 | 1.33% | ||
| 21 | EVENTIDE ASSET MANAGEMENT, LLC | 534,500 | 20,418,000 | 1.25% | ||
| 22 | NORTHERN TRUST CORP | 504,528 | 19,273,000 | 1.18% | ||
| 23 | SECTORAL ASSET MANAGEMENT INC | 476,500 | 18,202,000 | 1.11% | ||
| 24 | ArrowMark Colorado Holdings LLC | 371,076 | 14,175,000 | 0.87% | ||
| 25 | New Leaf Venture Partners, L.L.C. | 355,007 | 13,561,000 | 0.83% | ||
| 26 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 339,500 | 12,969,000 | 0.79% | ||
| 27 | Tourbillon Capital Partners, L.P. | 335,422 | 12,813,000 | 0.78% | ||
| 28 | LOOMIS SAYLES & CO L P | 335,220 | 12,806,000 | 0.78% | ||
| 29 | Opaleye Management Inc. | 310,000 | 11,842,000 | 0.73% | ||
| 30 | BRIDGER MANAGEMENT, LLC | 307,782 | 11,757,000 | 0.72% | ||
| 31 | MILLENNIUM MANAGEMENT LLC | 286,752 | 10,954,000 | 0.67% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 283,819 | 10,841,000 | 0.66% | ||
| 33 | DEUTSCHE BANK AG\ | 279,117 | 10,660,000 | 0.65% | ||
| 34 | NORGES BANK | 227,364 | 8,685,000 | 0.53% | ||
| 35 | Bank of New York Mellon Corp | 223,790 | 8,549,000 | 0.52% | ||
| 36 | Biondo Investment Advisors, LLC | 223,374 | 8,533,000 | 0.52% | ||
| 37 | C WorldWide Group Holding A/S | 221,950 | 8,478,000 | 0.52% | ||
| 38 | Asset Management One Co., Ltd. | 211,307 | 7,695,000 | 0.47% | ||
| 39 | AXA S.A. | 199,892 | 7,636,000 | 0.47% | ||
| 40 | EMERALD ADVISERS, LLC | 172,599 | 6,593,000 | 0.40% | ||
| 41 | EMERALD MUTUAL FUND ADVISERS TRUST | 170,800 | 6,525,000 | 0.40% | ||
| 42 | TIAA CREF INVESTMENT MANAGEMENT LLC | 159,210 | 6,082,000 | 0.37% | ||
| 43 | BlackRock Investment Management, LLC | 152,321 | 5,819,000 | 0.36% | ||
| 44 | GUGGENHEIM CAPITAL LLC | 150,866 | 5,763,000 | 0.35% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 134,334 | 5,132,000 | 0.31% | ||
| 46 | BAKER BROS. ADVISORS LP | 115,216 | 4,401,000 | 0.27% | ||
| 47 | Invesco Ltd. | 111,947 | 4,276,000 | 0.26% | ||
| 48 | Connor, Clark & Lunn Investment Management Ltd. | 111,900 | 4,275,000 | 0.26% | ||
| 49 | BANK OF AMERICA CORP /DE/ | 99,990 | 3,819,000 | 0.23% | ||
| 50 | FIL Ltd | 96,542 | 3,688,000 | 0.23% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
