| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,923,477 | 35,379,000 | 20.71% | ||
| 2 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 3,256,191 | 16,640,000 | 9.74% | ||
| 3 | VANGUARD GROUP INC | 2,208,614 | 11,286,000 | 6.61% | ||
| 4 | BlackRock Fund Advisors | 1,690,785 | 8,640,000 | 5.06% | ||
| 5 | Numeric Investors LLC | 1,341,170 | 6,853,000 | 4.01% | ||
| 6 | GREAT POINT PARTNERS LLC | 1,300,000 | 6,643,000 | 3.89% | ||
| 7 | JENNISON ASSOCIATES LLC | 1,284,070 | 6,562,000 | 3.84% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 1,217,905 | 6,223,000 | 3.64% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 1,132,524 | 5,787,000 | 3.39% | ||
| 10 | ArrowMark Colorado Holdings LLC | 938,211 | 4,794,000 | 2.81% | ||
| 11 | A.R.T. Advisors, LLC | 866,059 | 4,425,000 | 2.59% | ||
| 12 | STATE STREET CORP | 743,930 | 3,805,000 | 2.23% | ||
| 13 | FARALLON CAPITAL MANAGEMENT LLC | 695,000 | 3,551,000 | 2.08% | ||
| 14 | Opaleye Management Inc. | 675,000 | 3,449,000 | 2.02% | ||
| 15 | RENAISSANCE TECHNOLOGIES LLC | 640,388 | 3,272,000 | 1.92% | ||
| 16 | New Leaf Venture Partners, L.L.C. | 582,904 | 2,979,000 | 1.74% | ||
| 17 | Rhenman & Partners Asset Management AB | 500,000 | 2,555,000 | 1.50% | ||
| 18 | NORTHERN TRUST CORP | 493,410 | 2,521,000 | 1.48% | ||
| 19 | Aisling Capital LLC | 472,943 | 2,417,000 | 1.41% | ||
| 20 | TWO SIGMA INVESTMENTS, LP | 340,791 | 1,741,000 | 1.02% | ||
| 21 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 339,500 | 1,735,000 | 1.02% | ||
| 22 | Tekla Capital Management LLC | 308,892 | 1,578,000 | 0.92% | ||
| 23 | FT OPTIONS LLC | 287,712 | 1,470,000 | 0.86% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 286,085 | 1,461,000 | 0.86% | ||
| 25 | NORGES BANK | 227,364 | 1,162,000 | 0.68% | ||
| 26 | Bank of New York Mellon Corp | 222,543 | 1,137,000 | 0.67% | ||
| 27 | Quantitative Investment Management, LLC | 190,100 | 971,000 | 0.57% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 188,813 | 965,000 | 0.56% | ||
| 29 | QS Investors, LLC | 170,317 | 870,000 | 0.51% | ||
| 30 | MORGAN STANLEY | 167,815 | 857,000 | 0.50% | ||
| 31 | TURNER INVESTMENTS LLC | 163,730 | 837,000 | 0.49% | ||
| 32 | PRICE T ROWE ASSOCIATES INC /MD/ | 160,198 | 819,000 | 0.48% | ||
| 33 | BlackRock Investment Management, LLC | 156,121 | 798,000 | 0.47% | ||
| 34 | DEUTSCHE BANK AG\ | 152,200 | 777,000 | 0.45% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 136,065 | 696,000 | 0.41% | ||
| 36 | BAKER BROS. ADVISORS LP | 115,216 | 589,000 | 0.34% | ||
| 37 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 96,673 | 494,000 | 0.29% | ||
| 38 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 93,500 | 478,000 | 0.28% | ||
| 39 | BARCLAYS PLC | 85,000 | 425,000 | 0.25% | Put | |
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 82,461 | 421,000 | 0.25% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 79,500 | 406,000 | 0.24% | Put | |
| 42 | GROUP ONE TRADING LLC | 78,785 | 403,000 | 0.24% | ||
| 43 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 76,697 | 392,000 | 0.23% | ||
| 44 | DIMENSIONAL FUND ADVISORS LP | 75,508 | 386,000 | 0.23% | ||
| 45 | CITADEL ADVISORS LLC | 72,782 | 372,000 | 0.22% | ||
| 46 | TEACHERS ADVISORS, LLC | 69,074 | 353,000 | 0.21% | ||
| 47 | GOLDMAN SACHS GROUP INC | 68,204 | 349,000 | 0.20% | ||
| 48 | ALLIANCEBERNSTEIN L.P. | 67,000 | 342,000 | 0.20% | ||
| 49 | Trexquant Investment LP | 65,907 | 337,000 | 0.20% | ||
| 50 | Swiss National Bank | 65,800 | 324,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
