| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,162,906 | 232,280,000 | 16.79% | ||
| 2 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 3,402,263 | 128,233,000 | 9.27% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,857,964 | 107,717,000 | 7.79% | ||
| 4 | JANUS HENDERSON INVESTORS US LLC | 1,867,524 | 70,387,000 | 5.09% | ||
| 5 | VANGUARD GROUP INC | 1,675,095 | 63,134,000 | 4.56% | ||
| 6 | EAGLE ASSET MANAGEMENT INC | 1,432,605 | 53,994,000 | 3.90% | ||
| 7 | BlackRock Fund Advisors | 1,351,918 | 50,954,000 | 3.68% | ||
| 8 | JPMORGAN CHASE & CO | 1,288,543 | 48,566,000 | 3.51% | ||
| 9 | Aisling Capital LLC | 1,022,943 | 38,555,000 | 2.79% | ||
| 10 | STATE STREET CORP | 998,729 | 37,641,000 | 2.72% | ||
| 11 | ORACLE INVESTMENT MANAGEMENT INC | 963,898 | 36,329,000 | 2.63% | ||
| 12 | Tourbillon Capital Partners, L.P. | 875,000 | 32,979,000 | 2.38% | ||
| 13 | Redmile Group, LLC | 844,456 | 31,828,000 | 2.30% | ||
| 14 | CITADEL ADVISORS LLC | 751,701 | 28,332,000 | 2.05% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 712,848 | 26,867,000 | 1.94% | ||
| 16 | OAK RIDGE INVESTMENTS LLC | 620,172 | 23,374,000 | 1.69% | ||
| 17 | Opaleye Management Inc. | 565,000 | 21,295,000 | 1.54% | ||
| 18 | JENNISON ASSOCIATES LLC | 534,071 | 20,129,000 | 1.46% | ||
| 19 | BRIDGER MANAGEMENT, LLC | 473,256 | 17,837,000 | 1.29% | ||
| 20 | RS INVESTMENT MANAGEMENT CO LLC | 457,933 | 17,259,000 | 1.25% | ||
| 21 | EVENTIDE ASSET MANAGEMENT, LLC | 444,500 | 16,753,000 | 1.21% | ||
| 22 | ArrowMark Colorado Holdings LLC | 427,716 | 16,121,000 | 1.17% | ||
| 23 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 390,700 | 14,725,000 | 1.06% | ||
| 24 | NORTHERN TRUST CORP | 350,570 | 13,214,000 | 0.96% | ||
| 25 | LOOMIS SAYLES & CO L P | 295,302 | 11,130,000 | 0.80% | ||
| 26 | Asset Management One Co., Ltd. | 272,560 | 10,330,000 | 0.75% | ||
| 27 | New Leaf Venture Partners, L.L.C. | 251,608 | 9,483,000 | 0.69% | ||
| 28 | C WorldWide Group Holding A/S | 245,000 | 9,234,000 | 0.67% | ||
| 29 | Cormorant Asset Management, LP | 229,500 | 8,650,000 | 0.63% | ||
| 30 | BARCLAYS PLC | 218,600 | 8,088,000 | 0.58% | Put | |
| 31 | BARCLAYS PLC | 218,600 | 8,088,000 | 0.58% | Call | |
| 32 | Biondo Investment Advisors, LLC | 213,005 | 8,028,000 | 0.58% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 208,800 | 7,869,000 | 0.57% | ||
| 34 | AXA S.A. | 204,120 | 7,693,000 | 0.56% | ||
| 35 | Bank of New York Mellon Corp | 189,482 | 7,141,000 | 0.52% | ||
| 36 | LORD, ABBETT & CO. LLC | 150,555 | 5,675,000 | 0.41% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 132,600 | 4,998,000 | 0.36% | Call | |
| 38 | GUGGENHEIM CAPITAL LLC | 129,744 | 4,890,000 | 0.35% | ||
| 39 | Connor, Clark & Lunn Investment Management Ltd. | 129,300 | 4,873,000 | 0.35% | ||
| 40 | DEUTSCHE BANK AG\ | 127,213 | 4,792,000 | 0.35% | ||
| 41 | Nuveen Asset Management, LLC | 2,341 | 4,403,000 | 0.32% | ||
| 42 | BAKER BROS. ADVISORS LP | 115,216 | 4,342,000 | 0.31% | ||
| 43 | MORGAN STANLEY | 110,885 | 4,179,000 | 0.30% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 101,905 | 3,841,000 | 0.28% | ||
| 45 | PUTNAM INVESTMENTS LLC | 99,700 | 3,758,000 | 0.27% | ||
| 46 | VICTORY CAPITAL MANAGEMENT INC | 99,050 | 3,733,000 | 0.27% | ||
| 47 | AQR CAPITAL MANAGEMENT LLC | 96,300 | 3,630,000 | 0.26% | ||
| 48 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 92,785 | 3,498,000 | 0.25% | ||
| 49 | Nicholas Investment Partners, LP | 91,637 | 3,454,000 | 0.25% | ||
| 50 | MANAGED ACCOUNT ADVISORS LLC | 89,937 | 3,390,000 | 0.25% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
