| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,943,413 | 31,940,000 | 21.77% | ||
| 2 | Redmile Group, LLC | 3,345,959 | 15,391,000 | 10.49% | ||
| 3 | Numeric Investors LLC | 1,769,449 | 8,139,000 | 5.55% | ||
| 4 | VANGUARD GROUP INC | 1,634,363 | 7,519,000 | 5.12% | ||
| 5 | BlackRock Fund Advisors | 1,431,253 | 6,584,000 | 4.49% | ||
| 6 | EcoR1 Capital, LLC | 1,415,687 | 6,512,000 | 4.44% | ||
| 7 | Opaleye Management Inc. | 1,170,000 | 5,382,000 | 3.67% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 1,094,328 | 5,034,000 | 3.43% | ||
| 9 | ArrowMark Colorado Holdings LLC | 1,045,517 | 4,809,000 | 3.28% | ||
| 10 | STATE STREET CORP | 751,031 | 3,453,000 | 2.35% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 620,414 | 2,854,000 | 1.95% | ||
| 12 | NORTHERN TRUST CORP | 595,668 | 2,740,000 | 1.87% | ||
| 13 | D. E. Shaw & Co., Inc. | 549,706 | 2,529,000 | 1.72% | ||
| 14 | JPMORGAN CHASE & CO | 538,880 | 2,479,000 | 1.69% | ||
| 15 | Artal Group S.A. | 500,000 | 2,300,000 | 1.57% | ||
| 16 | DIMENSIONAL FUND ADVISORS LP | 485,409 | 2,233,000 | 1.52% | ||
| 17 | Aisling Capital LLC | 472,943 | 2,176,000 | 1.48% | ||
| 18 | Rhenman & Partners Asset Management AB | 400,000 | 1,840,000 | 1.25% | ||
| 19 | ACADIAN ASSET MANAGEMENT LLC | 329,655 | 1,516,000 | 1.03% | ||
| 20 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 315,729 | 1,452,000 | 0.99% | ||
| 21 | Tekla Capital Management LLC | 308,892 | 1,421,000 | 0.97% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 305,486 | 1,405,000 | 0.96% | ||
| 23 | TWO SIGMA INVESTMENTS, LP | 290,098 | 1,334,000 | 0.91% | ||
| 24 | PANAGORA ASSET MANAGEMENT INC | 286,590 | 1,318,000 | 0.90% | ||
| 25 | GSA CAPITAL PARTNERS LLP | 261,167 | 1,201,000 | 0.82% | ||
| 26 | PRESCOTT GROUP CAPITAL MANAGEMENT, L.L.C. | 260,936 | 1,200,000 | 0.82% | ||
| 27 | FIRST QUADRANT LLC/CA | 255,333 | 1,175,000 | 0.80% | ||
| 28 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 254,945 | 1,173,000 | 0.80% | ||
| 29 | PRUDENTIAL FINANCIAL INC | 248,740 | 1,144,000 | 0.78% | ||
| 30 | Bank of New York Mellon Corp | 228,963 | 1,054,000 | 0.72% | ||
| 31 | QS Investors, LLC | 226,678 | 1,043,000 | 0.71% | ||
| 32 | FT OPTIONS LLC | 205,266 | 944,000 | 0.64% | ||
| 33 | MORGAN STANLEY | 203,357 | 936,000 | 0.64% | ||
| 34 | BlackRock Investment Management, LLC | 184,679 | 850,000 | 0.58% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 177,185 | 815,000 | 0.56% | ||
| 36 | WELLS FARGO & COMPANY/MN | 142,853 | 657,000 | 0.45% | ||
| 37 | PRICE T ROWE ASSOCIATES INC /MD/ | 139,427 | 641,000 | 0.44% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 127,594 | 587,000 | 0.40% | ||
| 39 | BAKER BROS. ADVISORS LP | 115,216 | 530,000 | 0.36% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 101,418 | 467,000 | 0.32% | ||
| 41 | CITADEL ADVISORS LLC | 96,633 | 445,000 | 0.30% | ||
| 42 | AXA S.A. | 95,580 | 440,000 | 0.30% | ||
| 43 | CIGNA INVESTMENT ADVISORY CO INC | 93,090 | 428,000 | 0.29% | ||
| 44 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 87,916 | 404,000 | 0.28% | ||
| 45 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 80,600 | 371,000 | 0.25% | ||
| 46 | SABBY MANAGEMENT, LLC | 79,900 | 368,000 | 0.25% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 78,700 | 362,000 | 0.25% | Call | |
| 48 | ALLIANCEBERNSTEIN L.P. | 70,300 | 323,000 | 0.22% | ||
| 49 | Invesco Ltd. | 70,016 | 322,000 | 0.22% | ||
| 50 | TEACHERS ADVISORS, LLC | 69,888 | 321,000 | 0.22% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
