| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,918,015 | 61,916,000 | 19.72% | ||
| 2 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 3,099,222 | 27,738,000 | 8.83% | ||
| 3 | VANGUARD GROUP INC | 2,887,776 | 25,845,000 | 8.23% | ||
| 4 | JANUS HENDERSON INVESTORS US LLC | 2,269,016 | 20,308,000 | 6.47% | ||
| 5 | BlackRock Fund Advisors | 1,668,724 | 14,935,000 | 4.76% | ||
| 6 | JENNISON ASSOCIATES LLC | 1,273,779 | 11,400,000 | 3.63% | ||
| 7 | STATE STREET CORP | 1,184,337 | 10,597,000 | 3.37% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 1,093,817 | 9,790,000 | 3.12% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 938,953 | 8,404,000 | 2.68% | ||
| 10 | BRIDGER MANAGEMENT, LLC | 841,898 | 7,535,000 | 2.40% | ||
| 11 | ORACLE INVESTMENT MANAGEMENT INC | 736,421 | 6,591,000 | 2.10% | ||
| 12 | RS INVESTMENT MANAGEMENT CO LLC | 700,000 | 6,265,000 | 2.00% | ||
| 13 | JPMORGAN CHASE & CO | 603,172 | 5,399,000 | 1.72% | ||
| 14 | SECTORAL ASSET MANAGEMENT INC | 550,100 | 4,923,000 | 1.57% | ||
| 15 | NORTHERN TRUST CORP | 504,266 | 4,514,000 | 1.44% | ||
| 16 | Aisling Capital LLC | 472,943 | 4,233,000 | 1.35% | ||
| 17 | BARCLAYS PLC | 499,000 | 3,992,000 | 1.27% | Put | |
| 18 | ArrowMark Colorado Holdings LLC | 439,722 | 3,936,000 | 1.25% | ||
| 19 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 339,500 | 3,039,000 | 0.97% | ||
| 20 | FARALLON CAPITAL MANAGEMENT LLC | 325,000 | 2,909,000 | 0.93% | ||
| 21 | AXA S.A. | 296,981 | 2,658,000 | 0.85% | ||
| 22 | ALLIANCEBERNSTEIN L.P. | 67,000 | 2,559,000 | 0.81% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 283,330 | 2,535,000 | 0.81% | ||
| 24 | DEUTSCHE BANK AG\ | 277,162 | 2,479,000 | 0.79% | ||
| 25 | Rhenman & Partners Asset Management AB | 256,000 | 2,291,000 | 0.73% | ||
| 26 | TWO SIGMA INVESTMENTS, LP | 244,761 | 2,191,000 | 0.70% | ||
| 27 | Numeric Investors LLC | 232,000 | 2,076,000 | 0.66% | ||
| 28 | NORGES BANK | 227,364 | 2,035,000 | 0.65% | ||
| 29 | New Leaf Venture Partners, L.L.C. | 220,533 | 1,974,000 | 0.63% | ||
| 30 | Bank of New York Mellon Corp | 196,038 | 1,755,000 | 0.56% | ||
| 31 | MORGAN STANLEY | 187,163 | 1,674,000 | 0.53% | ||
| 32 | Asset Management One Co., Ltd. | 213,406 | 1,572,000 | 0.50% | ||
| 33 | PICTET ASSET MANAGEMENT LTD | 167,552 | 1,500,000 | 0.48% | ||
| 34 | PRICE T ROWE ASSOCIATES INC /MD/ | 160,198 | 1,434,000 | 0.46% | ||
| 35 | Gruss Capital Management LP | 160,000 | 1,432,000 | 0.46% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 155,318 | 1,390,000 | 0.44% | ||
| 37 | FT OPTIONS LLC | 154,100 | 1,379,000 | 0.44% | ||
| 38 | BlackRock Investment Management, LLC | 153,444 | 1,373,000 | 0.44% | ||
| 39 | Spark Investment Management LLC | 152,200 | 1,362,000 | 0.43% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 141,181 | 1,264,000 | 0.40% | ||
| 41 | C WorldWide Group Holding A/S | 132,000 | 1,181,000 | 0.38% | ||
| 42 | Trexquant Investment LP | 131,184 | 1,174,000 | 0.37% | ||
| 43 | GUGGENHEIM CAPITAL LLC | 121,120 | 1,084,000 | 0.35% | ||
| 44 | Invesco Ltd. | 119,451 | 1,069,000 | 0.34% | ||
| 45 | MILLENNIUM MANAGEMENT LLC | 117,900 | 1,055,000 | 0.34% | Put | |
| 46 | BAKER BROS. ADVISORS LP | 115,216 | 1,031,000 | 0.33% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 114,600 | 1,026,000 | 0.33% | Call | |
| 48 | EverPoint Asset Management, LLC | 100,000 | 895,000 | 0.29% | ||
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 99,600 | 891,000 | 0.28% | Put | |
| 50 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 99,200 | 888,000 | 0.28% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
