| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,928,070 | 27,227,000 | 21.93% | ||
| 2 | Redmile Group, LLC | 3,288,376 | 12,923,000 | 10.41% | ||
| 3 | Numeric Investors LLC | 2,073,774 | 8,150,000 | 6.57% | ||
| 4 | BlackRock Fund Advisors | 1,687,552 | 6,632,000 | 5.34% | ||
| 5 | VANGUARD GROUP INC | 1,635,630 | 6,427,000 | 5.18% | ||
| 6 | JENNISON ASSOCIATES LLC | 1,282,604 | 5,041,000 | 4.06% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 1,121,005 | 4,406,000 | 3.55% | ||
| 8 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 991,481 | 3,897,000 | 3.14% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 923,327 | 3,629,000 | 2.92% | ||
| 10 | STATE STREET CORP | 727,515 | 2,861,000 | 2.30% | ||
| 11 | Opaleye Management Inc. | 675,000 | 2,653,000 | 2.14% | ||
| 12 | FARALLON CAPITAL MANAGEMENT LLC | 593,138 | 2,331,000 | 1.88% | ||
| 13 | Rhenman & Partners Asset Management AB | 550,000 | 2,162,000 | 1.74% | ||
| 14 | NORTHERN TRUST CORP | 507,672 | 1,995,000 | 1.61% | ||
| 15 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 496,676 | 1,951,000 | 1.57% | ||
| 16 | ArrowMark Colorado Holdings LLC | 483,261 | 1,899,000 | 1.53% | ||
| 17 | TWO SIGMA INVESTMENTS, LP | 474,323 | 1,864,000 | 1.50% | ||
| 18 | Aisling Capital LLC | 472,943 | 1,859,000 | 1.50% | ||
| 19 | PANAGORA ASSET MANAGEMENT INC | 467,870 | 1,839,000 | 1.48% | ||
| 20 | Tekla Capital Management LLC | 308,892 | 1,214,000 | 0.98% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 289,897 | 1,139,000 | 0.92% | ||
| 22 | RENAISSANCE TECHNOLOGIES LLC | 265,265 | 1,042,000 | 0.84% | ||
| 23 | TIAA CREF INVESTMENT MANAGEMENT LLC | 227,506 | 894,000 | 0.72% | ||
| 24 | QS Investors, LLC | 221,053 | 869,000 | 0.70% | ||
| 25 | FT OPTIONS LLC | 220,266 | 866,000 | 0.70% | ||
| 26 | A.R.T. Advisors, LLC | 196,238 | 771,000 | 0.62% | ||
| 27 | Bank of New York Mellon Corp | 186,311 | 732,000 | 0.59% | ||
| 28 | BlackRock Investment Management, LLC | 185,972 | 731,000 | 0.59% | ||
| 29 | CITADEL ADVISORS LLC | 178,046 | 700,000 | 0.56% | ||
| 30 | DEUTSCHE BANK AG\ | 166,804 | 653,000 | 0.53% | ||
| 31 | PRICE T ROWE ASSOCIATES INC /MD/ | 160,298 | 630,000 | 0.51% | ||
| 32 | DIMENSIONAL FUND ADVISORS LP | 153,408 | 603,000 | 0.49% | ||
| 33 | MORGAN STANLEY | 139,796 | 550,000 | 0.44% | ||
| 34 | AXA S.A. | 138,980 | 546,000 | 0.44% | ||
| 35 | AQR CAPITAL MANAGEMENT LLC | 124,667 | 490,000 | 0.39% | ||
| 36 | BAKER BROS. ADVISORS LP | 115,216 | 453,000 | 0.36% | ||
| 37 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 98,258 | 386,000 | 0.31% | ||
| 38 | TWO SIGMA ADVISERS, LP | 91,500 | 360,000 | 0.29% | ||
| 39 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 90,600 | 356,000 | 0.29% | ||
| 40 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 89,516 | 352,000 | 0.28% | ||
| 41 | GSA CAPITAL PARTNERS LLP | 88,931 | 349,000 | 0.28% | ||
| 42 | Trexquant Investment LP | 85,613 | 336,000 | 0.27% | ||
| 43 | BARCLAYS PLC | 85,000 | 334,000 | 0.27% | Put | |
| 44 | D. E. Shaw & Co., Inc. | 83,679 | 329,000 | 0.27% | ||
| 45 | LOS ANGELES CAPITAL MANAGEMENT LLC | 81,945 | 322,000 | 0.26% | ||
| 46 | ALLIANCEBERNSTEIN L.P. | 80,300 | 316,000 | 0.25% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 79,586 | 313,000 | 0.25% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 74,400 | 292,000 | 0.24% | Call | |
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 73,400 | 288,000 | 0.23% | Put | |
| 50 | HAMILTON LANE ADVISORS LLC | 58,379 | 286,000 | 0.23% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
