| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,134,891 | 112,660,000 | 20.28% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,402,280 | 52,706,000 | 9.49% | ||
| 3 | JANUS HENDERSON INVESTORS US LLC | 1,790,058 | 39,274,000 | 7.07% | ||
| 4 | Aisling Capital LLC | 1,522,943 | 33,410,000 | 6.01% | ||
| 5 | Redmile Group, LLC | 1,337,150 | 29,337,000 | 5.28% | ||
| 6 | Point72 Asset Management, L.P. | 1,147,100 | 25,167,000 | 4.53% | ||
| 7 | BlackRock Fund Advisors | 1,069,948 | 23,475,000 | 4.22% | ||
| 8 | JPMORGAN CHASE & CO | 1,015,511 | 22,279,000 | 4.01% | ||
| 9 | Canaan Partners VII LLC | 861,664 | 18,905,000 | 3.40% | ||
| 10 | Opaleye Management Inc. | 790,000 | 17,333,000 | 3.12% | ||
| 11 | VANGUARD GROUP INC | 767,383 | 16,836,000 | 3.03% | ||
| 12 | SECTORAL ASSET MANAGEMENT INC | 631,894 | 13,864,000 | 2.50% | ||
| 13 | JENNISON ASSOCIATES LLC | 616,822 | 13,533,000 | 2.44% | ||
| 14 | LOOMIS SAYLES & CO L P | 593,003 | 13,010,000 | 2.34% | ||
| 15 | RS INVESTMENT MANAGEMENT CO LLC | 559,700 | 12,280,000 | 2.21% | ||
| 16 | EVENTIDE ASSET MANAGEMENT, LLC | 418,600 | 9,184,000 | 1.65% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 327,963 | 7,196,000 | 1.30% | ||
| 18 | STATE STREET CORP | 325,563 | 7,144,000 | 1.29% | ||
| 19 | CITADEL ADVISORS LLC | 321,701 | 7,058,000 | 1.27% | ||
| 20 | Cormorant Asset Management, LP | 300,000 | 6,582,000 | 1.18% | ||
| 21 | AXA S.A. | 220,000 | 4,827,000 | 0.87% | ||
| 22 | MILLENNIUM MANAGEMENT LLC | 200,236 | 4,393,000 | 0.79% | ||
| 23 | Private Capital Advisors, Inc. | 199,293 | 4,372,000 | 0.79% | ||
| 24 | NORTHERN TRUST CORP | 178,041 | 3,907,000 | 0.70% | ||
| 25 | Bank of New York Mellon Corp | 156,949 | 3,443,000 | 0.62% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 155,106 | 3,403,000 | 0.61% | ||
| 27 | PERCEPTIVE ADVISORS LLC | 148,000 | 3,241,000 | 0.58% | ||
| 28 | MORGAN STANLEY | 131,465 | 2,884,000 | 0.52% | ||
| 29 | EverPoint Asset Management, LLC | 120,000 | 2,633,000 | 0.47% | ||
| 30 | Nicholas Investment Partners, LP | 114,451 | 2,511,000 | 0.45% | ||
| 31 | TIAA CREF INVESTMENT MANAGEMENT LLC | 101,131 | 2,219,000 | 0.40% | ||
| 32 | PUTNAM INVESTMENTS LLC | 100,300 | 2,201,000 | 0.40% | ||
| 33 | CI INVESTMENTS INC. | 98,000 | 2,150,000 | 0.39% | ||
| 34 | Biondo Investment Advisors, LLC | 80,800 | 1,773,000 | 0.32% | ||
| 35 | TFS CAPITAL LLC | 78,693 | 1,727,000 | 0.31% | ||
| 36 | BlackRock Investment Management, LLC | 77,617 | 1,703,000 | 0.31% | ||
| 37 | REGENTS OF THE UNIVERSITY OF CALIFORNIA | 70,818 | 1,554,000 | 0.28% | ||
| 38 | WELLINGTON MANAGEMENT GROUP LLP | 68,066 | 1,493,000 | 0.27% | ||
| 39 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 64,713 | 1,420,000 | 0.26% | ||
| 40 | HIGHLAND CAPITAL MANAGEMENT LP | 54,440 | 1,194,000 | 0.21% | ||
| 41 | Hutchin Hill Capital, LP | 50,000 | 1,097,000 | 0.20% | ||
| 42 | DSC Advisors, L.P. | 50,000 | 1,097,000 | 0.20% | ||
| 43 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 49,191 | 1,079,000 | 0.19% | ||
| 44 | BLACKROCK ADVISORS LLC | 47,622 | 1,045,000 | 0.19% | ||
| 45 | PICTET ASSET MANAGEMENT LTD | 45,900 | 1,007,000 | 0.18% | ||
| 46 | Weiss Multi-Strategy Advisers LLC | 45,000 | 987,000 | 0.18% | ||
| 47 | ALLIANCEBERNSTEIN L.P. | 41,700 | 915,000 | 0.16% | ||
| 48 | TD ASSET MANAGEMENT INC | 41,400 | 908,000 | 0.16% | ||
| 49 | CREDIT SUISSE AG/ | 40,294 | 885,000 | 0.16% | ||
| 50 | TEACHERS ADVISORS, LLC | 37,978 | 833,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
