| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,017,763 | 242,275,000 | 16.39% | ||
| 2 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 3,141,925 | 126,495,000 | 8.56% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,417,262 | 97,319,000 | 6.58% | ||
| 4 | JANUS HENDERSON INVESTORS US LLC | 1,583,537 | 63,753,000 | 4.31% | ||
| 5 | Aisling Capital LLC | 1,522,943 | 61,314,000 | 4.15% | ||
| 6 | EAGLE ASSET MANAGEMENT INC | 1,394,462 | 56,141,000 | 3.80% | ||
| 7 | BlackRock Fund Advisors | 1,322,947 | 53,262,000 | 3.60% | ||
| 8 | JPMORGAN CHASE & CO | 1,254,353 | 50,500,000 | 3.42% | ||
| 9 | Redmile Group, LLC | 1,157,184 | 46,588,000 | 3.15% | ||
| 10 | New Leaf Venture Partners, L.L.C. | 1,068,300 | 43,010,000 | 2.91% | ||
| 11 | ROYAL LONDON ASSET MANAGEMENT LTD | 109,800 | 41,570,000 | 2.81% | ||
| 12 | VANGUARD GROUP INC | 1,010,914 | 40,700,000 | 2.75% | ||
| 13 | ORACLE INVESTMENT MANAGEMENT INC | 969,400 | 39,028,000 | 2.64% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 941,606 | 37,909,000 | 2.56% | ||
| 15 | STATE STREET CORP | 915,583 | 36,859,000 | 2.49% | ||
| 16 | Opaleye Management Inc. | 805,000 | 32,409,000 | 2.19% | ||
| 17 | CITADEL ADVISORS LLC | 641,345 | 25,821,000 | 1.75% | ||
| 18 | RS INVESTMENT MANAGEMENT CO LLC | 625,850 | 25,197,000 | 1.70% | ||
| 19 | JENNISON ASSOCIATES LLC | 530,994 | 21,378,000 | 1.45% | ||
| 20 | ArrowMark Colorado Holdings LLC | 523,464 | 21,075,000 | 1.43% | ||
| 21 | BlackRock Institutional Trust Company, N.A. | 504,245 | 20,301,000 | 1.37% | ||
| 22 | Point72 Asset Management, L.P. | 488,482 | 19,666,000 | 1.33% | ||
| 23 | Tourbillon Capital Partners, L.P. | 450,000 | 18,117,000 | 1.23% | ||
| 24 | EVENTIDE ASSET MANAGEMENT, LLC | 418,600 | 16,853,000 | 1.14% | ||
| 25 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 418,600 | 16,853,000 | 1.14% | ||
| 26 | Cormorant Asset Management, LP | 400,000 | 16,104,000 | 1.09% | ||
| 27 | BRIDGER MANAGEMENT, LLC | 395,712 | 15,931,000 | 1.08% | ||
| 28 | LOOMIS SAYLES & CO L P | 367,420 | 14,793,000 | 1.00% | ||
| 29 | NORTHERN TRUST CORP | 338,556 | 13,630,000 | 0.92% | ||
| 30 | Asset Management One Co., Ltd. | 260,516 | 9,962,000 | 0.67% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 231,761 | 9,330,000 | 0.63% | ||
| 32 | Biondo Investment Advisors, LLC | 195,305 | 7,863,000 | 0.53% | ||
| 33 | Bank of New York Mellon Corp | 190,034 | 7,650,000 | 0.52% | ||
| 34 | AXA S.A. | 189,705 | 7,638,000 | 0.52% | ||
| 35 | BAKER BROS. ADVISORS LP | 172,414 | 6,941,000 | 0.47% | ||
| 36 | Nicholas Investment Partners, LP | 126,695 | 5,101,000 | 0.35% | ||
| 37 | Connor, Clark & Lunn Investment Management Ltd. | 120,300 | 4,843,000 | 0.33% | ||
| 38 | MORGAN STANLEY | 116,388 | 4,686,000 | 0.32% | ||
| 39 | GUGGENHEIM CAPITAL LLC | 110,820 | 4,462,000 | 0.30% | ||
| 40 | LORD, ABBETT & CO. LLC | 104,915 | 4,224,000 | 0.29% | ||
| 41 | DEUTSCHE BANK AG\ | 103,260 | 4,156,000 | 0.28% | ||
| 42 | PUTNAM INVESTMENTS LLC | 99,700 | 4,014,000 | 0.27% | ||
| 43 | TIAA CREF INVESTMENT MANAGEMENT LLC | 96,249 | 3,875,000 | 0.26% | ||
| 44 | MANAGED ACCOUNT ADVISORS LLC | 88,216 | 3,551,000 | 0.24% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 88,100 | 3,547,000 | 0.24% | ||
| 46 | BlackRock Investment Management, LLC | 86,716 | 3,491,000 | 0.24% | ||
| 47 | BNP Paribas Asset Management Holding S.A. | 86,240 | 3,472,000 | 0.23% | ||
| 48 | Iguana Healthcare Management, LLC | 75,000 | 3,020,000 | 0.20% | ||
| 49 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 74,783 | 2,966,000 | 0.20% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 70,700 | 2,846,000 | 0.19% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
