| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,843,796 | 316,183,000 | 16.56% | ||
| 2 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 3,579,386 | 165,369,000 | 8.66% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,005,422 | 138,850,000 | 7.27% | ||
| 4 | VANGUARD GROUP INC | 2,498,229 | 115,418,000 | 6.05% | ||
| 5 | JANUS HENDERSON INVESTORS US LLC | 2,387,650 | 110,309,000 | 5.78% | ||
| 6 | BlackRock Fund Advisors | 1,552,891 | 71,744,000 | 3.76% | ||
| 7 | EAGLE ASSET MANAGEMENT INC | 1,427,319 | 65,942,000 | 3.45% | ||
| 8 | STATE STREET CORP | 1,221,014 | 56,409,000 | 2.95% | ||
| 9 | JPMORGAN CHASE & CO | 1,052,153 | 48,609,000 | 2.55% | ||
| 10 | ORACLE INVESTMENT MANAGEMENT INC | 1,025,921 | 47,398,000 | 2.48% | ||
| 11 | Aisling Capital LLC | 1,022,943 | 47,260,000 | 2.48% | ||
| 12 | ORBIMED ADVISORS LLC | 1,021,600 | 47,198,000 | 2.47% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 808,917 | 37,372,000 | 1.96% | ||
| 14 | JENNISON ASSOCIATES LLC | 763,186 | 35,259,000 | 1.85% | ||
| 15 | Redmile Group, LLC | 699,425 | 32,313,000 | 1.69% | ||
| 16 | RS INVESTMENT MANAGEMENT CO LLC | 658,833 | 30,438,000 | 1.59% | ||
| 17 | OAK RIDGE INVESTMENTS LLC | 654,841 | 30,253,000 | 1.58% | ||
| 18 | CITADEL ADVISORS LLC | 588,591 | 27,193,000 | 1.42% | ||
| 19 | Tourbillon Capital Partners, L.P. | 525,000 | 24,255,000 | 1.27% | ||
| 20 | EVENTIDE ASSET MANAGEMENT, LLC | 490,800 | 22,675,000 | 1.19% | ||
| 21 | ArrowMark Colorado Holdings LLC | 484,171 | 22,369,000 | 1.17% | ||
| 22 | SECTORAL ASSET MANAGEMENT INC | 474,900 | 21,940,000 | 1.15% | ||
| 23 | Opaleye Management Inc. | 440,000 | 20,328,000 | 1.06% | ||
| 24 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 390,700 | 18,050,000 | 0.95% | ||
| 25 | NORTHERN TRUST CORP | 356,992 | 16,493,000 | 0.86% | ||
| 26 | LOOMIS SAYLES & CO L P | 331,630 | 15,321,000 | 0.80% | ||
| 27 | New Leaf Venture Partners, L.L.C. | 320,608 | 14,812,000 | 0.78% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 275,819 | 12,742,000 | 0.67% | ||
| 29 | C WorldWide Group Holding A/S | 274,000 | 12,659,000 | 0.66% | ||
| 30 | Asset Management One Co., Ltd. | 266,309 | 11,922,000 | 0.62% | ||
| 31 | Bank of New York Mellon Corp | 239,074 | 11,045,000 | 0.58% | ||
| 32 | Biondo Investment Advisors, LLC | 222,422 | 10,276,000 | 0.54% | ||
| 33 | LORD, ABBETT & CO. LLC | 212,153 | 9,801,000 | 0.51% | ||
| 34 | NORGES BANK | 207,745 | 9,598,000 | 0.50% | ||
| 35 | AXA S.A. | 204,120 | 9,430,000 | 0.49% | ||
| 36 | MILLENNIUM MANAGEMENT LLC | 173,571 | 8,019,000 | 0.42% | ||
| 37 | EMERALD ADVISERS, LLC | 168,865 | 7,802,000 | 0.41% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 168,300 | 7,775,000 | 0.41% | Call | |
| 39 | GUGGENHEIM CAPITAL LLC | 157,245 | 7,265,000 | 0.38% | ||
| 40 | DEUTSCHE BANK AG\ | 143,513 | 6,628,000 | 0.35% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 140,920 | 6,511,000 | 0.34% | ||
| 42 | BlackRock Investment Management, LLC | 139,755 | 6,457,000 | 0.34% | ||
| 43 | EMERALD MUTUAL FUND ADVISERS TRUST | 133,920 | 6,187,000 | 0.32% | ||
| 44 | Connor, Clark & Lunn Investment Management Ltd. | 121,000 | 5,590,000 | 0.29% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 116,525 | 5,384,000 | 0.28% | ||
| 46 | BAKER BROS. ADVISORS LP | 115,216 | 5,323,000 | 0.28% | ||
| 47 | MORGAN STANLEY | 107,332 | 4,959,000 | 0.26% | ||
| 48 | PUTNAM INVESTMENTS LLC | 100,200 | 4,629,000 | 0.24% | ||
| 49 | AQR CAPITAL MANAGEMENT LLC | 94,994 | 4,389,000 | 0.23% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 93,500 | 4,320,000 | 0.23% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
