| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,655,916 | 72,679,000 | 19.89% | ||
| 2 | BVF INC/IL | 4,260,836 | 54,752,000 | 14.98% | ||
| 3 | BlackRock Finance, Inc. | 3,041,882 | 39,089,000 | 10.70% | ||
| 4 | LANSDOWNE PARTNERS (UK) LLP | 2,321,865 | 29,836,000 | 8.16% | ||
| 5 | VANGUARD GROUP INC | 1,949,345 | 25,049,000 | 6.85% | ||
| 6 | WASATCH ADVISORS LP | 1,492,698 | 19,181,000 | 5.25% | ||
| 7 | WELLINGTON MANAGEMENT GROUP LLP | 1,350,009 | 17,347,000 | 4.75% | ||
| 8 | STATE STREET CORP | 932,426 | 11,981,000 | 3.28% | ||
| 9 | CITIGROUP INC | 728,660 | 9,363,000 | 2.56% | ||
| 10 | BALYASNY ASSET MANAGEMENT L.P. | 507,500 | 6,521,000 | 1.78% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 404,428 | 5,197,000 | 1.42% | ||
| 12 | NORTHERN TRUST CORP | 380,427 | 4,889,000 | 1.34% | ||
| 13 | ACADIAN ASSET MANAGEMENT LLC | 334,806 | 4,302,000 | 1.18% | ||
| 14 | GEODE CAPITAL MANAGEMENT, LLC | 296,683 | 3,812,000 | 1.04% | ||
| 15 | MORGAN STANLEY | 282,311 | 3,628,000 | 0.99% | ||
| 16 | HIGHLAND CAPITAL MANAGEMENT LP | 215,000 | 2,763,000 | 0.76% | ||
| 17 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 208,781 | 2,682,000 | 0.73% | ||
| 18 | OXFORD ASSET MANAGEMENT LLP | 193,868 | 2,491,000 | 0.68% | ||
| 19 | TWO SIGMA INVESTMENTS, LP | 181,418 | 2,331,000 | 0.64% | ||
| 20 | D. E. Shaw & Co., Inc. | 167,102 | 2,148,000 | 0.59% | ||
| 21 | RUSSELL INVESTMENTS GROUP, LTD. | 166,329 | 2,137,000 | 0.58% | ||
| 22 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 159,096 | 2,045,000 | 0.56% | ||
| 23 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 156,990 | 2,017,000 | 0.55% | ||
| 24 | SPHERA FUNDS MANAGEMENT LTD. | 152,200 | 1,956,000 | 0.54% | ||
| 25 | Bank of New York Mellon Corp | 149,645 | 1,923,000 | 0.53% | ||
| 26 | GSA CAPITAL PARTNERS LLP | 131,502 | 1,690,000 | 0.46% | ||
| 27 | Palo Alto Investors LP | 123,686 | 1,589,000 | 0.43% | ||
| 28 | IRONWOOD INVESTMENT MANAGEMENT LLC | 118,102 | 1,518,000 | 0.42% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 107,548 | 1,382,000 | 0.38% | ||
| 30 | Invesco Ltd. | 99,897 | 1,284,000 | 0.35% | ||
| 31 | TFS CAPITAL LLC | 95,987 | 1,233,000 | 0.34% | ||
| 32 | ClariVest Asset Management LLC | 89,176 | 1,145,000 | 0.31% | ||
| 33 | Allianz Asset Management GmbH | 84,476 | 1,086,000 | 0.30% | ||
| 34 | PNC FINANCIAL SERVICES GROUP, INC. | 83,821 | 1,078,000 | 0.30% | ||
| 35 | DEUTSCHE BANK AG\ | 83,994 | 1,077,000 | 0.29% | ||
| 36 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 82,675 | 1,062,000 | 0.29% | ||
| 37 | Timpani Capital Management LLC | 67,551 | 868,000 | 0.24% | ||
| 38 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 66,708 | 857,000 | 0.23% | ||
| 39 | Spark Investment Management LLC | 65,700 | 844,000 | 0.23% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 65,200 | 838,000 | 0.23% | Call | |
| 41 | Trexquant Investment LP | 62,381 | 802,000 | 0.22% | ||
| 42 | TEACHERS ADVISORS, LLC | 60,326 | 775,000 | 0.21% | ||
| 43 | GOLDMAN SACHS GROUP INC | 51,430 | 661,000 | 0.18% | ||
| 44 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 51,066 | 656,000 | 0.18% | ||
| 45 | Gotham Asset Management, LLC | 49,907 | 641,000 | 0.18% | ||
| 46 | SIMPLEX TRADING, LLC | 48,194 | 619,000 | 0.17% | ||
| 47 | Piermont Capital Management Inc. | 47,618 | 612,000 | 0.17% | ||
| 48 | SHELL ASSET MANAGEMENT CO | 42,875 | 551,000 | 0.15% | ||
| 49 | Airain ltd | 41,748 | 536,000 | 0.15% | ||
| 50 | TWO SIGMA ADVISERS, LP | 40,500 | 520,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
