| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PERCEPTIVE ADVISORS LLC | 4,407,317 | 76,907,000 | 15.57% | ||
| 2 | FMR LLC | 3,842,476 | 67,051,000 | 13.57% | ||
| 3 | BlackRock Finance, Inc. | 2,381,977 | 41,565,000 | 8.41% | ||
| 4 | Aisling Capital LLC | 2,024,465 | 35,327,000 | 7.15% | ||
| 5 | BAKER BROS. ADVISORS LP | 1,660,593 | 28,977,000 | 5.87% | ||
| 6 | SOFINNOVA MANAGEMENT VIII, L.L.C. | 1,563,260 | 27,279,000 | 5.52% | ||
| 7 | FEDERATED HERMES, INC. | 1,452,150 | 25,340,000 | 5.13% | ||
| 8 | New Leaf Venture Partners, L.L.C. | 1,448,296 | 25,273,000 | 5.12% | ||
| 9 | VANGUARD GROUP INC | 1,121,401 | 19,569,000 | 3.96% | ||
| 10 | JPMORGAN CHASE & CO | 1,079,187 | 18,832,000 | 3.81% | ||
| 11 | STATE STREET CORP | 556,718 | 9,716,000 | 1.97% | ||
| 12 | ArrowMark Colorado Holdings LLC | 464,851 | 8,112,000 | 1.64% | ||
| 13 | NORTHERN TRUST CORP | 420,553 | 7,339,000 | 1.49% | ||
| 14 | SPHERA FUNDS MANAGEMENT LTD. | 377,524 | 6,588,000 | 1.33% | ||
| 15 | RENAISSANCE TECHNOLOGIES LLC | 362,510 | 6,326,000 | 1.28% | ||
| 16 | Artal Group S.A. | 350,000 | 6,108,000 | 1.24% | ||
| 17 | LORD, ABBETT & CO. LLC | 319,854 | 5,582,000 | 1.13% | ||
| 18 | TIAA CREF INVESTMENT MANAGEMENT LLC | 288,960 | 5,042,000 | 1.02% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 261,506 | 4,563,000 | 0.92% | ||
| 20 | NF TRINITY CAPITAL (HONG KONG) LTD | 244,897 | 4,273,000 | 0.86% | ||
| 21 | DRIEHAUS CAPITAL MANAGEMENT LLC | 211,079 | 3,683,000 | 0.75% | ||
| 22 | PRINCIPAL FINANCIAL GROUP INC | 187,600 | 3,274,000 | 0.66% | ||
| 23 | DLD ASSET MANAGEMENT, LP | 173,900 | 3,029,000 | 0.61% | Call | |
| 24 | MILLENNIUM MANAGEMENT LLC | 153,345 | 2,676,000 | 0.54% | ||
| 25 | Bank of New York Mellon Corp | 152,247 | 2,657,000 | 0.54% | ||
| 26 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 117,043 | 2,042,000 | 0.41% | ||
| 27 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 109,409 | 1,910,000 | 0.39% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 105,800 | 1,846,000 | 0.37% | Call | |
| 29 | ClariVest Asset Management LLC | 105,758 | 1,845,000 | 0.37% | ||
| 30 | SECTORAL ASSET MANAGEMENT INC | 104,757 | 1,828,000 | 0.37% | ||
| 31 | GOLDMAN SACHS GROUP INC | 103,044 | 1,798,000 | 0.36% | ||
| 32 | DEUTSCHE BANK AG\ | 98,400 | 1,716,000 | 0.35% | ||
| 33 | EMORY UNIVERSITY | 97,944 | 1,709,000 | 0.35% | ||
| 34 | AMERIPRISE FINANCIAL INC | 87,690 | 1,530,000 | 0.31% | ||
| 35 | SECOR Capital Advisors, LP | 86,972 | 1,518,000 | 0.31% | ||
| 36 | Allianz Asset Management GmbH | 83,482 | 1,457,000 | 0.29% | ||
| 37 | BANK OF MONTREAL /CAN/ | 78,468 | 1,369,000 | 0.28% | ||
| 38 | ALLIANCEBERNSTEIN L.P. | 75,210 | 1,312,000 | 0.27% | ||
| 39 | TEACHERS ADVISORS, LLC | 71,317 | 1,244,000 | 0.25% | ||
| 40 | CITADEL ADVISORS LLC | 67,714 | 1,182,000 | 0.24% | ||
| 41 | NEW YORK STATE COMMON RETIREMENT FUND | 67,415 | 1,176,000 | 0.24% | ||
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 57,795 | 1,009,000 | 0.20% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 52,800 | 921,000 | 0.19% | Put | |
| 44 | SCHONFELD STRATEGIC ADVISORS LLC | 50,000 | 873,000 | 0.18% | ||
| 45 | ACUTA CAPITAL PARTNERS, LLC | 49,100 | 857,000 | 0.17% | Put | |
| 46 | WELLINGTON MANAGEMENT GROUP LLP | 43,631 | 761,000 | 0.15% | ||
| 47 | Nationwide Fund Advisors | 42,829 | 747,000 | 0.15% | ||
| 48 | STRS OHIO | 42,300 | 738,000 | 0.15% | ||
| 49 | JACOBS LEVY EQUITY MANAGEMENT, INC | 41,678 | 727,000 | 0.15% | ||
| 50 | Swiss National Bank | 40,200 | 701,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
