| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FRANKLIN RESOURCES INC | 6,076,879 | 27,650,000 | 24.28% | ||
| 2 | FMR LLC | 4,391,885 | 19,983,000 | 17.55% | ||
| 3 | EcoR1 Capital, LLC | 2,537,026 | 11,543,000 | 10.14% | ||
| 4 | Polaris Venture Management Co. V, L.L.C. | 2,473,186 | 11,253,000 | 9.88% | ||
| 5 | BVF INC/IL | 1,945,245 | 8,851,000 | 7.77% | ||
| 6 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,711,958 | 7,789,000 | 6.84% | ||
| 7 | Redmile Group, LLC | 1,419,058 | 6,457,000 | 5.67% | ||
| 8 | VANGUARD GROUP INC | 1,155,679 | 5,258,000 | 4.62% | ||
| 9 | MORGAN STANLEY | 611,646 | 2,783,000 | 2.44% | ||
| 10 | 683 Capital Management, LLC | 470,000 | 2,139,000 | 1.88% | ||
| 11 | RENAISSANCE TECHNOLOGIES LLC | 295,700 | 1,345,000 | 1.18% | ||
| 12 | WELLS FARGO & COMPANY/MN | 281,111 | 1,279,000 | 1.12% | ||
| 13 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 250,000 | 1,138,000 | 1.00% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 195,928 | 891,000 | 0.78% | ||
| 15 | Telemetry Investments, L.L.C. | 150,000 | 682,000 | 0.60% | ||
| 16 | GOLDMAN SACHS GROUP INC | 144,053 | 655,000 | 0.58% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 119,514 | 543,000 | 0.48% | ||
| 18 | BlackRock Finance, Inc. | 86,289 | 392,000 | 0.34% | ||
| 19 | Neuberger Berman Group LLC | 68,600 | 312,000 | 0.27% | ||
| 20 | JACOBS LEVY EQUITY MANAGEMENT, INC | 60,704 | 276,000 | 0.24% | ||
| 21 | Bank of New York Mellon Corp | 59,510 | 271,000 | 0.24% | ||
| 22 | TFS CAPITAL LLC | 54,598 | 248,000 | 0.22% | ||
| 23 | Connor, Clark & Lunn Investment Management Ltd. | 41,300 | 188,000 | 0.17% | ||
| 24 | Segantii Capital Management Ltd | 39,999 | 182,000 | 0.16% | ||
| 25 | Hillsdale Investment Management Inc. | 35,200 | 160,000 | 0.14% | ||
| 26 | NORTHERN TRUST CORP | 34,455 | 157,000 | 0.14% | ||
| 27 | DRIEHAUS CAPITAL MANAGEMENT LLC | 31,790 | 145,000 | 0.13% | ||
| 28 | PANAGORA ASSET MANAGEMENT INC | 29,510 | 134,000 | 0.12% | ||
| 29 | Squarepoint Ops LLC | 28,900 | 131,000 | 0.12% | ||
| 30 | BARCLAYS PLC | 25,143 | 115,000 | 0.10% | ||
| 31 | Virtu KCG Holdings LLC | 24,480 | 111,000 | 0.10% | ||
| 32 | Creative Planning | 23,000 | 105,000 | 0.09% | ||
| 33 | Dynamic Technology Lab Private Ltd | 21,654 | 99,000 | 0.09% | ||
| 34 | GLG Partners LP | 20,754 | 94,000 | 0.08% | ||
| 35 | BlueCrest Capital Management Ltd | 17,728 | 81,000 | 0.07% | ||
| 36 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 15,000 | 68,000 | 0.06% | ||
| 37 | CERITY PARTNERS LLC | 13,920 | 63,000 | 0.06% | ||
| 38 | CITADEL ADVISORS LLC | 13,746 | 63,000 | 0.06% | ||
| 39 | Invesco Ltd. | 12,465 | 57,000 | 0.05% | ||
| 40 | CREDIT SUISSE AG/ | 12,372 | 56,000 | 0.05% | ||
| 41 | ACROSPIRE INVESTMENT MANAGEMENT LLC | 8,822 | 40,000 | 0.04% | ||
| 42 | Community Bank, N.A. | 6,500 | 30,000 | 0.03% | ||
| 43 | IFP ADVISORS, INC | 5,400 | 25,000 | 0.02% | ||
| 44 | JPMORGAN CHASE & CO | 2,166 | 10,000 | 0.01% | ||
| 45 | ADVISOR GROUP, INC. | 2,000 | 9,000 | 0.01% | ||
| 46 | FIRST MANHATTAN CO. LLC. | 1,250 | 5,000 | 0.00% | ||
| 47 | Vigilant Capital Management, LLC | 1,000 | 5,000 | 0.00% | ||
| 48 | FEDERATED HERMES, INC. | 1,170 | 5,000 | 0.00% | ||
| 49 | D.A. DAVIDSON & CO. | 720 | 3,000 | 0.00% | ||
| 50 | TCI Wealth Advisors, Inc. | 500 | 2,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
