| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 13,659,264 | 480,806,000 | 46.35% | ||
| 2 | Camber Capital Management LP | 2,458,100 | 86,525,000 | 8.34% | ||
| 3 | BAILLIE GIFFORD & CO | 1,429,209 | 50,309,000 | 4.85% | ||
| 4 | MILLENNIUM MANAGEMENT LLC | 1,306,004 | 45,971,000 | 4.43% | ||
| 5 | VANGUARD GROUP INC | 1,289,850 | 45,403,000 | 4.38% | ||
| 6 | BlackRock Fund Advisors | 813,704 | 28,642,000 | 2.76% | ||
| 7 | DEERFIELD MANAGEMENT COMPANY, L.P. | 809,432 | 28,492,000 | 2.75% | ||
| 8 | FMR LLC | 570,348 | 20,076,000 | 1.94% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 562,234 | 19,791,000 | 1.91% | ||
| 10 | BLACKROCK ADVISORS LLC | 526,413 | 18,530,000 | 1.79% | ||
| 11 | STATE STREET CORP | 478,108 | 16,830,000 | 1.62% | ||
| 12 | RENAISSANCE TECHNOLOGIES LLC | 289,600 | 10,194,000 | 0.98% | ||
| 13 | TPG Group Holdings (SBS) Advisors, Inc. | 260,273 | 9,162,000 | 0.88% | ||
| 14 | STATE FARM MUTUAL AUTOMOBILE INSURANCE CO | 260,181 | 9,158,000 | 0.88% | ||
| 15 | NORTHERN TRUST CORP | 220,864 | 7,775,000 | 0.75% | ||
| 16 | BlackRock Group LTD | 183,075 | 6,445,000 | 0.62% | ||
| 17 | Tributary Capital Management, LLC | 178,769 | 6,293,000 | 0.61% | ||
| 18 | MARSHALL WACE, LLP | 173,219 | 6,097,000 | 0.59% | ||
| 19 | CASDIN CAPITAL, LLC | 165,000 | 5,808,000 | 0.56% | ||
| 20 | Mitsubishi UFJ Trust & Banking Corp | 161,670 | 5,691,000 | 0.55% | ||
| 21 | OPPENHEIMER & CO INC | 146,379 | 5,153,000 | 0.50% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 139,433 | 4,907,000 | 0.47% | ||
| 23 | Motley Fool Asset Management LLC | 131,935 | 4,644,000 | 0.45% | ||
| 24 | LORD, ABBETT & CO. LLC | 131,464 | 4,628,000 | 0.45% | ||
| 25 | Candriam S.C.A. | 128,000 | 4,506,000 | 0.43% | ||
| 26 | TWO SIGMA INVESTMENTS, LP | 127,369 | 4,483,000 | 0.43% | ||
| 27 | MORGAN STANLEY | 115,434 | 4,064,000 | 0.39% | ||
| 28 | GSA CAPITAL PARTNERS LLP | 112,260 | 3,952,000 | 0.38% | ||
| 29 | Motley Fool Wealth Management, LLC | 106,180 | 3,738,000 | 0.36% | ||
| 30 | NORGES BANK | 105,192 | 3,703,000 | 0.36% | ||
| 31 | Visium Asset Management, LP | 102,100 | 3,594,000 | 0.35% | ||
| 32 | RUSSELL FRANK CO/ | 99,754 | 3,517,000 | 0.34% | ||
| 33 | Zweig-DiMenna Associates LLC | 93,759 | 3,300,000 | 0.32% | ||
| 34 | TWO SIGMA ADVISERS, LP | 89,773 | 3,160,000 | 0.30% | ||
| 35 | BlackRock Investment Management, LLC | 88,934 | 3,130,000 | 0.30% | ||
| 36 | Bank of New York Mellon Corp | 81,491 | 2,868,000 | 0.28% | ||
| 37 | ACADIAN ASSET MANAGEMENT LLC | 80,532 | 2,834,000 | 0.27% | ||
| 38 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 77,200 | 2,717,000 | 0.26% | ||
| 39 | SKANDINAVISKA ENSKILDA BANKEN AB (PUBL) | 75,600 | 2,661,000 | 0.26% | ||
| 40 | JACOBS LEVY EQUITY MANAGEMENT, INC | 69,883 | 2,460,000 | 0.24% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 68,016 | 2,394,000 | 0.23% | ||
| 42 | ROYCE & ASSOCIATES LP | 66,500 | 2,341,000 | 0.23% | ||
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 65,765 | 2,315,000 | 0.22% | ||
| 44 | TFS CAPITAL LLC | 62,222 | 2,190,000 | 0.21% | ||
| 45 | Connor, Clark & Lunn Investment Management Ltd. | 60,100 | 2,116,000 | 0.20% | ||
| 46 | Spark Investment Management LLC | 57,300 | 2,016,000 | 0.19% | ||
| 47 | MACQUARIE GROUP LTD | 55,000 | 1,936,000 | 0.19% | ||
| 48 | WELLS FARGO & COMPANY/MN | 53,186 | 1,873,000 | 0.18% | ||
| 49 | CORRADO ADVISORS, LLC | 48,695 | 1,714,000 | 0.17% | ||
| 50 | BlackRock Finance, Inc. | 46,272 | 1,629,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
