| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRICE T ROWE ASSOCIATES INC /MD/ | 7,050,858 | 318,910,000 | 14.31% | ||
| 2 | FMR LLC | 5,203,915 | 235,373,000 | 10.56% | ||
| 3 | BB BIOTECH AG | 5,038,799 | 227,905,000 | 10.23% | ||
| 4 | MPM ASSET MANAGEMENT LLC | 3,887,502 | 175,832,000 | 7.89% | ||
| 5 | FARALLON CAPITAL MANAGEMENT LLC | 3,686,300 | 166,731,000 | 7.48% | ||
| 6 | VANGUARD GROUP INC | 3,145,717 | 142,281,000 | 6.39% | ||
| 7 | BlackRock Finance, Inc. | 2,893,641 | 130,881,000 | 5.87% | ||
| 8 | STATE STREET CORP | 1,867,531 | 84,473,000 | 3.79% | ||
| 9 | Tourbillon Capital Partners, L.P. | 1,439,821 | 65,123,000 | 2.92% | ||
| 10 | Rock Springs Capital Management LP | 910,250 | 41,171,000 | 1.85% | ||
| 11 | CITADEL ADVISORS LLC | 815,522 | 36,886,000 | 1.66% | ||
| 12 | ORBIMED ADVISORS LLC | 704,100 | 31,846,000 | 1.43% | ||
| 13 | PERCEPTIVE ADVISORS LLC | 645,873 | 29,212,000 | 1.31% | ||
| 14 | TimesSquare Capital Management, LLC | 565,750 | 25,589,000 | 1.15% | ||
| 15 | VOYA INVESTMENT MANAGEMENT LLC | 552,315 | 24,982,000 | 1.12% | ||
| 16 | Bank of New York Mellon Corp | 529,865 | 23,965,000 | 1.08% | ||
| 17 | RA CAPITAL MANAGEMENT, L.P. | 497,157 | 22,486,000 | 1.01% | ||
| 18 | PICTET ASSET MANAGEMENT LTD | 641,388 | 22,205,000 | 1.00% | ||
| 19 | MILLENNIUM MANAGEMENT LLC | 489,444 | 22,138,000 | 0.99% | ||
| 20 | Bain Capital Public Equity Management, LLC | 457,437 | 20,690,000 | 0.93% | ||
| 21 | FRANKLIN RESOURCES INC | 432,600 | 19,566,000 | 0.88% | ||
| 22 | NORTHERN TRUST CORP | 430,835 | 19,487,000 | 0.87% | ||
| 23 | ROYAL BANK OF CANADA | 405,825 | 18,356,000 | 0.82% | ||
| 24 | Fiera Capital Corp | 394,672 | 17,851,000 | 0.80% | ||
| 25 | MILLENNIUM MANAGEMENT LLC | 350,000 | 15,831,000 | 0.71% | Call | |
| 26 | ALLIANCEBERNSTEIN L.P. | 345,494 | 15,627,000 | 0.70% | ||
| 27 | DEUTSCHE BANK AG\ | 337,376 | 15,257,000 | 0.68% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 320,740 | 14,507,000 | 0.65% | ||
| 29 | CREDIT AGRICOLE S A | 272,900 | 12,343,000 | 0.55% | ||
| 30 | NORGES BANK | 246,050 | 11,128,000 | 0.50% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 240,000 | 10,855,000 | 0.49% | Call | |
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 210,200 | 9,507,000 | 0.43% | Put | |
| 33 | PERCEPTIVE ADVISORS LLC | 200,000 | 9,046,000 | 0.41% | Put | |
| 34 | Artal Group S.A. | 200,000 | 9,046,000 | 0.41% | Call | |
| 35 | BANK OF AMERICA CORP /DE/ | 196,175 | 8,873,000 | 0.40% | ||
| 36 | GOLDMAN SACHS GROUP INC | 170,049 | 7,692,000 | 0.35% | ||
| 37 | Artal Group S.A. | 150,000 | 6,785,000 | 0.30% | ||
| 38 | CAPITAL FUND MANAGEMENT S.A. | 148,809 | 6,731,000 | 0.30% | ||
| 39 | TD ASSET MANAGEMENT INC | 145,970 | 6,602,000 | 0.30% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 140,895 | 6,373,000 | 0.29% | ||
| 41 | MORGAN STANLEY | 129,325 | 5,850,000 | 0.26% | ||
| 42 | FOLGER HILL ASSET MANAGEMENT LP | 125,976 | 5,698,000 | 0.26% | ||
| 43 | JPMORGAN CHASE & CO | 120,554 | 5,452,000 | 0.24% | ||
| 44 | Candriam S.C.A. | 115,000 | 5,202,000 | 0.23% | ||
| 45 | INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 114,799 | 5,194,000 | 0.23% | ||
| 46 | TIAA CREF INVESTMENT MANAGEMENT LLC | 100,526 | 4,547,000 | 0.20% | ||
| 47 | Camber Capital Management LP | 100,000 | 4,523,000 | 0.20% | ||
| 48 | NEW YORK STATE COMMON RETIREMENT FUND | 95,082 | 4,301,000 | 0.19% | ||
| 49 | Allianz Asset Management GmbH | 76,055 | 3,415,000 | 0.15% | ||
| 50 | Rhenman & Partners Asset Management AB | 75,000 | 3,392,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
