| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 11,375,395 | 168,811,000 | 15.97% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 10,255,239 | 152,188,000 | 14.40% | ||
| 3 | ORBIMED ADVISORS LLC | 4,675,700 | 69,364,000 | 6.56% | ||
| 4 | PERCEPTIVE ADVISORS LLC | 4,599,867 | 68,262,000 | 6.46% | ||
| 5 | BB BIOTECH AG | 3,086,552 | 45,789,000 | 4.33% | ||
| 6 | BlackRock Fund Advisors | 2,577,323 | 38,235,000 | 3.62% | ||
| 7 | VANGUARD GROUP INC | 2,215,157 | 32,873,000 | 3.11% | ||
| 8 | FRANKLIN RESOURCES INC | 2,204,200 | 32,710,000 | 3.10% | ||
| 9 | STATE STREET CORP | 2,171,880 | 32,232,000 | 3.05% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 2,079,490 | 30,849,000 | 2.92% | ||
| 11 | Visium Asset Management, LP | 1,784,421 | 26,481,000 | 2.51% | ||
| 12 | ArrowMark Colorado Holdings LLC | 1,656,673 | 24,577,000 | 2.33% | ||
| 13 | GREAT POINT PARTNERS LLC | 1,512,103 | 22,432,000 | 2.12% | ||
| 14 | Capital World Investors | 1,150,200 | 17,069,000 | 1.62% | ||
| 15 | LOOMIS SAYLES & CO L P | 1,058,233 | 15,704,000 | 1.49% | ||
| 16 | BLACKROCK ADVISORS LLC | 1,037,829 | 15,396,000 | 1.46% | ||
| 17 | NORTHERN TRUST CORP | 914,299 | 13,563,000 | 1.28% | ||
| 18 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 889,898 | 13,206,000 | 1.25% | ||
| 19 | WELLINGTON MANAGEMENT GROUP LLP | 851,163 | 12,631,000 | 1.20% | ||
| 20 | DEUTSCHE BANK AG\ | 842,366 | 12,495,000 | 1.18% | ||
| 21 | Tekla Capital Management LLC | 790,490 | 11,731,000 | 1.11% | ||
| 22 | JANUS HENDERSON INVESTORS US LLC | 721,488 | 10,707,000 | 1.01% | ||
| 23 | THRIVENT FINANCIAL FOR LUTHERANS | 671,563 | 9,963,000 | 0.94% | ||
| 24 | GOLDMAN SACHS GROUP INC | 622,079 | 9,229,000 | 0.87% | ||
| 25 | BAKER BROS. ADVISORS LP | 554,590 | 8,230,000 | 0.78% | ||
| 26 | AMUNDI ASSET MANAGEMENT US, INC. | 511,617 | 7,592,000 | 0.72% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 414,096 | 6,145,000 | 0.58% | ||
| 28 | MILLENNIUM MANAGEMENT LLC | 408,941 | 6,067,000 | 0.57% | ||
| 29 | Bank of New York Mellon Corp | 370,318 | 5,493,000 | 0.52% | ||
| 30 | AXA S.A. | 362,145 | 5,374,000 | 0.51% | ||
| 31 | LORD, ABBETT & CO. LLC | 316,368 | 4,695,000 | 0.44% | ||
| 32 | Rock Springs Capital Management LP | 310,000 | 4,600,000 | 0.44% | ||
| 33 | TIAA CREF INVESTMENT MANAGEMENT LLC | 308,762 | 4,582,000 | 0.43% | ||
| 34 | TURNER INVESTMENTS LLC | 303,950 | 4,509,000 | 0.43% | ||
| 35 | VHCP Management, LLC | 303,503 | 4,502,000 | 0.43% | ||
| 36 | Cormorant Asset Management, LP | 300,000 | 4,451,000 | 0.42% | ||
| 37 | Allianz Asset Management GmbH | 278,210 | 4,127,000 | 0.39% | ||
| 38 | CITADEL ADVISORS LLC | 268,134 | 3,979,000 | 0.38% | ||
| 39 | BlackRock Investment Management, LLC | 262,825 | 3,899,000 | 0.37% | ||
| 40 | EMERALD MUTUAL FUND ADVISERS TRUST | 259,363 | 3,848,000 | 0.36% | ||
| 41 | EMERALD ADVISERS, LLC | 239,990 | 3,560,000 | 0.34% | ||
| 42 | BlackRock Group LTD | 238,829 | 3,543,000 | 0.34% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 220,200 | 3,268,000 | 0.31% | Call | |
| 44 | TD ASSET MANAGEMENT INC | 206,900 | 3,070,000 | 0.29% | ||
| 45 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 205,300 | 3,047,000 | 0.29% | Put | |
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 200,019 | 2,969,000 | 0.28% | ||
| 47 | AQR CAPITAL MANAGEMENT LLC | 194,000 | 2,879,000 | 0.27% | ||
| 48 | GUGGENHEIM CAPITAL LLC | 189,727 | 2,816,000 | 0.27% | ||
| 49 | CREDIT SUISSE AG/ | 176,921 | 2,625,000 | 0.25% | ||
| 50 | QS BATTERYMARCH FINANCIAL MANAGEMENT, INC | 151,421 | 2,247,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
