| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 11,298,586 | 181,907,000 | 16.01% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 10,256,939 | 165,137,000 | 14.53% | ||
| 3 | ORBIMED ADVISORS LLC | 5,451,000 | 87,761,000 | 7.72% | ||
| 4 | PERCEPTIVE ADVISORS LLC | 4,619,367 | 74,372,000 | 6.54% | ||
| 5 | BB BIOTECH AG | 2,996,552 | 48,244,000 | 4.25% | ||
| 6 | BlackRock Fund Advisors | 2,808,536 | 45,217,000 | 3.98% | ||
| 7 | STATE STREET CORP | 2,243,649 | 36,124,000 | 3.18% | ||
| 8 | VANGUARD GROUP INC | 2,221,142 | 35,760,000 | 3.15% | ||
| 9 | FRANKLIN RESOURCES INC | 2,204,200 | 35,488,000 | 3.12% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 2,083,849 | 33,550,000 | 2.95% | ||
| 11 | Visium Asset Management, LP | 2,000,935 | 32,216,000 | 2.84% | ||
| 12 | ArrowMark Colorado Holdings LLC | 1,256,421 | 20,228,000 | 1.78% | ||
| 13 | RA CAPITAL MANAGEMENT, L.P. | 1,169,084 | 18,822,000 | 1.66% | ||
| 14 | Capital World Investors | 1,150,200 | 18,518,000 | 1.63% | ||
| 15 | BLACKROCK ADVISORS LLC | 1,064,000 | 17,131,000 | 1.51% | ||
| 16 | NORTHERN TRUST CORP | 996,182 | 16,039,000 | 1.41% | ||
| 17 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 889,898 | 14,327,000 | 1.26% | ||
| 18 | LOOMIS SAYLES & CO L P | 869,364 | 13,996,000 | 1.23% | ||
| 19 | GOLDMAN SACHS GROUP INC | 741,570 | 11,939,000 | 1.05% | ||
| 20 | DEUTSCHE BANK AG\ | 736,883 | 11,861,000 | 1.04% | ||
| 21 | JANUS HENDERSON INVESTORS US LLC | 673,664 | 10,846,000 | 0.95% | ||
| 22 | THRIVENT FINANCIAL FOR LUTHERANS | 671,990 | 10,819,000 | 0.95% | ||
| 23 | GREAT POINT PARTNERS LLC | 620,000 | 9,982,000 | 0.88% | ||
| 24 | WELLINGTON MANAGEMENT GROUP LLP | 566,643 | 9,123,000 | 0.80% | ||
| 25 | TURNER INVESTMENTS LLC | 544,770 | 8,770,000 | 0.77% | ||
| 26 | AQR CAPITAL MANAGEMENT LLC | 454,964 | 7,325,000 | 0.64% | ||
| 27 | BAKER BROS. ADVISORS LP | 447,874 | 7,211,000 | 0.63% | ||
| 28 | AMUNDI ASSET MANAGEMENT US, INC. | 434,514 | 6,996,000 | 0.62% | ||
| 29 | Tekla Capital Management LLC | 427,790 | 6,887,000 | 0.61% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 405,729 | 6,532,000 | 0.57% | ||
| 31 | Bank of New York Mellon Corp | 366,996 | 5,909,000 | 0.52% | ||
| 32 | AXA S.A. | 307,468 | 4,950,000 | 0.44% | ||
| 33 | VHCP Management, LLC | 303,503 | 4,886,000 | 0.43% | ||
| 34 | Rock Springs Capital Management LP | 300,000 | 4,830,000 | 0.43% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 294,036 | 4,734,000 | 0.42% | ||
| 36 | Allianz Asset Management GmbH | 281,400 | 4,531,000 | 0.40% | ||
| 37 | BlackRock Group LTD | 248,936 | 4,008,000 | 0.35% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 242,300 | 3,901,000 | 0.34% | Call | |
| 39 | CREDIT SUISSE AG/ | 238,628 | 3,842,000 | 0.34% | ||
| 40 | EMERALD MUTUAL FUND ADVISERS TRUST | 238,560 | 3,841,000 | 0.34% | ||
| 41 | EMERALD ADVISERS, LLC | 238,410 | 3,838,000 | 0.34% | ||
| 42 | LORD, ABBETT & CO. LLC | 237,141 | 3,818,000 | 0.34% | ||
| 43 | GUGGENHEIM CAPITAL LLC | 226,130 | 3,641,000 | 0.32% | ||
| 44 | TD ASSET MANAGEMENT INC | 216,800 | 3,490,000 | 0.31% | ||
| 45 | BlackRock Investment Management, LLC | 207,747 | 3,345,000 | 0.29% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 187,631 | 3,021,000 | 0.27% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 174,000 | 2,801,000 | 0.25% | Put | |
| 48 | QS BATTERYMARCH FINANCIAL MANAGEMENT, INC | 171,921 | 2,768,000 | 0.24% | ||
| 49 | JPMORGAN CHASE & CO | 140,449 | 2,261,000 | 0.20% | ||
| 50 | GOLDMAN SACHS GROUP INC | 140,400 | 2,260,000 | 0.20% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
