| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 12,880,978 | 512,534,000 | 14.99% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 8,770,009 | 348,959,000 | 10.21% | ||
| 3 | VANGUARD GROUP INC | 5,762,338 | 229,284,000 | 6.71% | ||
| 4 | ORBIMED ADVISORS LLC | 3,816,050 | 151,841,000 | 4.44% | ||
| 5 | BlackRock Fund Advisors | 3,342,688 | 133,006,000 | 3.89% | ||
| 6 | BB BIOTECH AG | 3,171,552 | 126,196,000 | 3.69% | ||
| 7 | PERCEPTIVE ADVISORS LLC | 2,942,967 | 117,101,000 | 3.43% | ||
| 8 | Visium Asset Management, LP | 2,199,505 | 87,518,000 | 2.56% | ||
| 9 | Invesco Ltd. | 2,184,320 | 86,915,000 | 2.54% | ||
| 10 | STATE STREET CORP | 2,019,393 | 80,354,000 | 2.35% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 1,972,180 | 78,473,000 | 2.30% | ||
| 12 | JANUS HENDERSON INVESTORS US LLC | 1,562,649 | 62,178,000 | 1.82% | ||
| 13 | ALPS ADVISORS INC | 134,411 | 53,482,000 | 1.56% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 1,325,374 | 52,737,000 | 1.54% | ||
| 15 | Capital World Investors | 1,242,500 | 49,439,000 | 1.45% | ||
| 16 | FRANKLIN RESOURCES INC | 1,240,700 | 49,367,000 | 1.44% | ||
| 17 | WESTFIELD CAPITAL MANAGEMENT CO LP | 1,145,845 | 45,593,000 | 1.33% | ||
| 18 | EAGLE ASSET MANAGEMENT INC | 1,112,132 | 44,251,000 | 1.29% | ||
| 19 | DEUTSCHE BANK AG\ | 1,035,518 | 41,200,000 | 1.21% | ||
| 20 | NORTHERN TRUST CORP | 1,025,218 | 40,793,000 | 1.19% | ||
| 21 | JENNISON ASSOCIATES LLC | 871,419 | 34,674,000 | 1.01% | ||
| 22 | RS INVESTMENT MANAGEMENT CO LLC | 838,960 | 33,382,000 | 0.98% | ||
| 23 | BLACKROCK ADVISORS LLC | 833,599 | 33,169,000 | 0.97% | ||
| 24 | BAKER BROS. ADVISORS LP | 750,739 | 29,872,000 | 0.87% | ||
| 25 | Cormorant Asset Management, LP | 718,900 | 28,605,000 | 0.84% | ||
| 26 | NORGES BANK | 715,388 | 28,466,000 | 0.83% | ||
| 27 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 614,059 | 24,433,000 | 0.71% | ||
| 28 | PointState Capital LP | 587,662 | 23,383,000 | 0.68% | ||
| 29 | VOYA INVESTMENT MANAGEMENT LLC | 577,430 | 22,976,000 | 0.67% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 535,797 | 21,319,000 | 0.62% | ||
| 31 | ArrowMark Colorado Holdings LLC | 533,022 | 21,209,000 | 0.62% | ||
| 32 | LORD, ABBETT & CO. LLC | 528,182 | 21,016,000 | 0.61% | ||
| 33 | MILLENNIUM MANAGEMENT LLC | 500,000 | 19,895,000 | 0.58% | Call | |
| 34 | CITADEL ADVISORS LLC | 478,198 | 19,028,000 | 0.56% | ||
| 35 | D. E. Shaw & Co., Inc. | 474,552 | 18,882,000 | 0.55% | ||
| 36 | COLUMBUS CIRCLE INVESTORS | 463,055 | 18,425,000 | 0.54% | ||
| 37 | Tourbillon Capital Partners, L.P. | 452,090 | 17,989,000 | 0.53% | ||
| 38 | Bank of New York Mellon Corp | 417,388 | 16,608,000 | 0.49% | ||
| 39 | WELLINGTON MANAGEMENT GROUP LLP | 386,804 | 15,391,000 | 0.45% | ||
| 40 | Tekla Capital Management LLC | 375,860 | 14,955,000 | 0.44% | ||
| 41 | Rock Springs Capital Management LP | 374,000 | 14,881,000 | 0.44% | ||
| 42 | CADIAN CAPITAL MANAGEMENT, LP | 360,397 | 14,340,000 | 0.42% | ||
| 43 | TEACHERS ADVISORS, LLC | 333,424 | 13,267,000 | 0.39% | ||
| 44 | BlackRock Investment Management, LLC | 326,012 | 12,972,000 | 0.38% | ||
| 45 | GOLDMAN SACHS GROUP INC | 321,974 | 12,812,000 | 0.37% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 315,854 | 12,568,000 | 0.37% | ||
| 47 | CAPITAL FUND MANAGEMENT S.A. | 309,709 | 12,323,000 | 0.36% | ||
| 48 | GOLDMAN SACHS GROUP INC | 305,400 | 12,152,000 | 0.36% | Call | |
| 49 | TIAA CREF INVESTMENT MANAGEMENT LLC | 305,177 | 12,143,000 | 0.36% | ||
| 50 | LOOMIS SAYLES & CO L P | 292,691 | 11,646,000 | 0.34% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
