| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 12,696,807 | 577,070,000 | 14.67% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 9,194,854 | 417,906,000 | 10.62% | ||
| 3 | VANGUARD GROUP INC | 6,079,369 | 276,307,000 | 7.02% | ||
| 4 | BB BIOTECH AG | 3,121,552 | 141,875,000 | 3.61% | ||
| 5 | PERCEPTIVE ADVISORS LLC | 2,797,967 | 127,167,000 | 3.23% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 2,166,573 | 98,469,000 | 2.50% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 2,014,672 | 91,567,000 | 2.33% | ||
| 8 | BlackRock Fund Advisors | 1,944,712 | 88,387,000 | 2.25% | ||
| 9 | STATE STREET CORP | 1,916,402 | 87,101,000 | 2.21% | ||
| 10 | ORBIMED ADVISORS LLC | 1,815,474 | 82,513,000 | 2.10% | ||
| 11 | Invesco Ltd. | 1,603,961 | 72,900,000 | 1.85% | ||
| 12 | FRANKLIN RESOURCES INC | 1,541,446 | 70,059,000 | 1.78% | ||
| 13 | Capital World Investors | 1,481,000 | 67,311,000 | 1.71% | ||
| 14 | WESTFIELD CAPITAL MANAGEMENT CO LP | 1,275,575 | 57,975,000 | 1.47% | ||
| 15 | DEUTSCHE BANK AG\ | 1,263,091 | 57,405,000 | 1.46% | ||
| 16 | JPMORGAN CHASE & CO | 1,246,904 | 56,671,000 | 1.44% | ||
| 17 | ALLIANCEBERNSTEIN L.P. | 1,104,515 | 50,200,000 | 1.28% | ||
| 18 | SECTORAL ASSET MANAGEMENT INC | 1,012,206 | 46,005,000 | 1.17% | ||
| 19 | BLACKROCK ADVISORS LLC | 960,256 | 43,644,000 | 1.11% | ||
| 20 | EAGLE ASSET MANAGEMENT INC | 941,653 | 42,798,000 | 1.09% | ||
| 21 | CITADEL ADVISORS LLC | 933,545 | 42,430,000 | 1.08% | ||
| 22 | NORGES BANK | 898,654 | 40,844,000 | 1.04% | ||
| 23 | BAKER BROS. ADVISORS LP | 895,422 | 40,697,000 | 1.03% | ||
| 24 | Senator Investment Group LP | 850,000 | 38,632,000 | 0.98% | ||
| 25 | OppenheimerFunds, Inc. | 831,868 | 37,808,000 | 0.96% | ||
| 26 | AMERICAN CENTURY COMPANIES INC | 821,527 | 37,338,000 | 0.95% | ||
| 27 | PICTET ASSET MANAGEMENT LTD | 705,229 | 35,015,000 | 0.89% | ||
| 28 | Tekla Capital Management LLC | 767,022 | 34,861,000 | 0.89% | ||
| 29 | ArrowMark Colorado Holdings LLC | 761,460 | 34,608,000 | 0.88% | ||
| 30 | GOLDMAN SACHS GROUP INC | 640,639 | 29,117,000 | 0.74% | ||
| 31 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 617,677 | 28,073,000 | 0.71% | ||
| 32 | FIRST TRUST ADVISORS LP | 617,037 | 28,044,000 | 0.71% | ||
| 33 | MILLENNIUM MANAGEMENT LLC | 614,576 | 27,932,000 | 0.71% | ||
| 34 | GEODE CAPITAL MANAGEMENT, LLC | 553,431 | 25,153,000 | 0.64% | ||
| 35 | Avoro Capital Advisors LLC | 509,330 | 23,149,000 | 0.59% | ||
| 36 | ROYAL BANK OF CANADA | 477,152 | 21,686,000 | 0.55% | ||
| 37 | GREAT POINT PARTNERS LLC | 470,000 | 21,362,000 | 0.54% | ||
| 38 | Alyeska Investment Group, L.P. | 461,132 | 20,958,000 | 0.53% | ||
| 39 | WELLINGTON MANAGEMENT GROUP LLP | 460,074 | 20,910,000 | 0.53% | ||
| 40 | NORTHERN TRUST CORP | 455,366 | 20,696,000 | 0.53% | ||
| 41 | HealthCor Management, L.P. | 450,000 | 20,453,000 | 0.52% | ||
| 42 | LORD, ABBETT & CO. LLC | 444,887 | 20,220,000 | 0.51% | ||
| 43 | TimesSquare Capital Management, LLC | 437,300 | 19,875,000 | 0.51% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 422,300 | 19,194,000 | 0.49% | Call | |
| 45 | Bank of New York Mellon Corp | 415,550 | 18,886,000 | 0.48% | ||
| 46 | Rock Springs Capital Management LP | 409,500 | 18,612,000 | 0.47% | ||
| 47 | VOYA INVESTMENT MANAGEMENT LLC | 399,555 | 18,160,000 | 0.46% | ||
| 48 | Cormorant Asset Management, LP | 398,301 | 18,103,000 | 0.46% | ||
| 49 | JENNISON ASSOCIATES LLC | 369,812 | 16,808,000 | 0.43% | ||
| 50 | BlackRock Group LTD | 352,103 | 16,003,000 | 0.41% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
