| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 12,967,607 | 512,869,000 | 14.69% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 9,575,744 | 378,721,000 | 10.85% | ||
| 3 | VANGUARD GROUP INC | 6,086,722 | 240,730,000 | 6.90% | ||
| 4 | BlackRock Fund Advisors | 3,223,549 | 127,491,000 | 3.65% | ||
| 5 | BB BIOTECH AG | 3,121,552 | 123,457,000 | 3.54% | ||
| 6 | PERCEPTIVE ADVISORS LLC | 2,720,967 | 107,614,000 | 3.08% | ||
| 7 | STATE STREET CORP | 2,682,064 | 106,077,000 | 3.04% | ||
| 8 | ORBIMED ADVISORS LLC | 2,653,874 | 104,961,000 | 3.01% | ||
| 9 | Invesco Ltd. | 2,382,901 | 94,244,000 | 2.70% | ||
| 10 | JANUS HENDERSON INVESTORS US LLC | 2,231,585 | 88,262,000 | 2.53% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 2,031,667 | 80,352,000 | 2.30% | ||
| 12 | Visium Asset Management, LP | 1,864,222 | 73,731,000 | 2.11% | ||
| 13 | CITADEL ADVISORS LLC | 1,811,663 | 71,651,000 | 2.05% | ||
| 14 | SECTORAL ASSET MANAGEMENT INC | 1,649,963 | 65,256,000 | 1.87% | ||
| 15 | Capital World Investors | 1,481,000 | 58,574,000 | 1.68% | ||
| 16 | WESTFIELD CAPITAL MANAGEMENT CO LP | 1,318,500 | 52,147,000 | 1.49% | ||
| 17 | FRANKLIN RESOURCES INC | 1,160,605 | 45,902,000 | 1.31% | ||
| 18 | MILLENNIUM MANAGEMENT LLC | 1,088,915 | 43,067,000 | 1.23% | ||
| 19 | NORTHERN TRUST CORP | 1,052,533 | 41,628,000 | 1.19% | ||
| 20 | EAGLE ASSET MANAGEMENT INC | 1,019,217 | 40,310,000 | 1.15% | ||
| 21 | BLACKROCK ADVISORS LLC | 1,017,883 | 40,257,000 | 1.15% | ||
| 22 | DEUTSCHE BANK AG\ | 908,775 | 35,939,000 | 1.03% | ||
| 23 | BAKER BROS. ADVISORS LP | 895,422 | 35,414,000 | 1.01% | ||
| 24 | GOLDMAN SACHS GROUP INC | 783,239 | 30,977,000 | 0.89% | ||
| 25 | ArrowMark Colorado Holdings LLC | 725,110 | 28,678,000 | 0.82% | ||
| 26 | HealthCor Management, L.P. | 725,000 | 28,674,000 | 0.82% | ||
| 27 | NORGES BANK | 717,413 | 28,374,000 | 0.81% | ||
| 28 | JPMORGAN CHASE & CO | 656,355 | 25,957,000 | 0.74% | ||
| 29 | FIRST TRUST ADVISORS LP | 638,287 | 25,244,000 | 0.72% | ||
| 30 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 628,260 | 24,847,000 | 0.71% | ||
| 31 | Cormorant Asset Management, LP | 603,900 | 23,884,000 | 0.68% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 582,969 | 23,056,000 | 0.66% | ||
| 33 | VOYA INVESTMENT MANAGEMENT LLC | 559,530 | 22,129,000 | 0.63% | ||
| 34 | OppenheimerFunds, Inc. | 522,560 | 20,667,000 | 0.59% | ||
| 35 | ROYAL BANK OF CANADA | 462,703 | 18,298,000 | 0.52% | ||
| 36 | Bank of New York Mellon Corp | 451,798 | 17,867,000 | 0.51% | ||
| 37 | WELLINGTON MANAGEMENT GROUP LLP | 420,172 | 16,618,000 | 0.48% | ||
| 38 | Avoro Capital Advisors LLC | 405,320 | 16,030,000 | 0.46% | ||
| 39 | Rock Springs Capital Management LP | 404,500 | 15,998,000 | 0.46% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 395,970 | 15,661,000 | 0.45% | ||
| 41 | JENNISON ASSOCIATES LLC | 370,240 | 14,643,000 | 0.42% | ||
| 42 | BLUE JAY CAPITAL MANAGEMENT, LLC | 356,510 | 14,100,000 | 0.40% | ||
| 43 | TIAA CREF INVESTMENT MANAGEMENT LLC | 351,198 | 13,890,000 | 0.40% | ||
| 44 | BlackRock Investment Management, LLC | 349,094 | 13,807,000 | 0.40% | ||
| 45 | Alyeska Investment Group, L.P. | 341,693 | 13,514,000 | 0.39% | ||
| 46 | GREAT POINT PARTNERS LLC | 325,300 | 12,866,000 | 0.37% | ||
| 47 | EMERALD ADVISERS, LLC | 313,544 | 12,401,000 | 0.36% | ||
| 48 | BlackRock Group LTD | 311,971 | 12,338,000 | 0.35% | ||
| 49 | Tekla Capital Management LLC | 311,460 | 12,318,000 | 0.35% | ||
| 50 | BROWN ADVISORY INC | 309,489 | 12,240,000 | 0.35% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
