| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 11,400,773 | 254,693,000 | 14.49% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 10,069,239 | 224,947,000 | 12.80% | ||
| 3 | ORBIMED ADVISORS LLC | 5,968,600 | 133,339,000 | 7.59% | ||
| 4 | PERCEPTIVE ADVISORS LLC | 3,565,267 | 79,648,000 | 4.53% | ||
| 5 | BB BIOTECH AG | 3,086,552 | 68,954,000 | 3.92% | ||
| 6 | BlackRock Fund Advisors | 2,849,268 | 63,653,000 | 3.62% | ||
| 7 | Visium Asset Management, LP | 2,461,840 | 54,999,000 | 3.13% | ||
| 8 | VANGUARD GROUP INC | 2,361,579 | 52,758,000 | 3.00% | ||
| 9 | STATE STREET CORP | 2,087,694 | 46,639,000 | 2.65% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 2,038,516 | 45,540,000 | 2.59% | ||
| 11 | FRANKLIN RESOURCES INC | 1,926,000 | 43,027,000 | 2.45% | ||
| 12 | Capital World Investors | 1,150,200 | 38,716,000 | 2.20% | ||
| 13 | PERCEPTIVE ADVISORS LLC | 1,600,000 | 35,744,000 | 2.03% | Put | |
| 14 | ArrowMark Colorado Holdings LLC | 1,473,489 | 32,918,000 | 1.87% | ||
| 15 | JANUS HENDERSON INVESTORS US LLC | 1,276,364 | 28,514,000 | 1.62% | ||
| 16 | MILLENNIUM MANAGEMENT LLC | 1,221,666 | 27,292,000 | 1.55% | ||
| 17 | CITADEL ADVISORS LLC | 1,118,226 | 24,981,000 | 1.42% | ||
| 18 | DEUTSCHE BANK AG\ | 1,006,421 | 22,482,000 | 1.28% | ||
| 19 | Tekla Capital Management LLC | 1,000,350 | 22,348,000 | 1.27% | ||
| 20 | Cormorant Asset Management, LP | 1,000,000 | 22,340,000 | 1.27% | ||
| 21 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 960,198 | 21,451,000 | 1.22% | ||
| 22 | BLACKROCK ADVISORS LLC | 906,835 | 20,259,000 | 1.15% | ||
| 23 | NORTHERN TRUST CORP | 895,889 | 20,013,000 | 1.14% | ||
| 24 | JENNISON ASSOCIATES LLC | 882,155 | 19,707,000 | 1.12% | ||
| 25 | WELLINGTON MANAGEMENT GROUP LLP | 818,918 | 18,295,000 | 1.04% | ||
| 26 | PointState Capital LP | 750,000 | 16,755,000 | 0.95% | ||
| 27 | THRIVENT FINANCIAL FOR LUTHERANS | 645,413 | 14,419,000 | 0.82% | ||
| 28 | FRED ALGER MANAGEMENT, LLC | 625,811 | 13,981,000 | 0.80% | ||
| 29 | COLUMBUS CIRCLE INVESTORS | 565,843 | 12,641,000 | 0.72% | ||
| 30 | BAKER BROS. ADVISORS LP | 554,590 | 12,390,000 | 0.71% | ||
| 31 | EMERALD ADVISERS, LLC | 540,973 | 12,085,000 | 0.69% | ||
| 32 | LOOMIS SAYLES & CO L P | 475,840 | 10,630,000 | 0.60% | ||
| 33 | Allianz Asset Management GmbH | 460,420 | 10,285,000 | 0.59% | ||
| 34 | EMERALD MUTUAL FUND ADVISERS TRUST | 454,857 | 10,162,000 | 0.58% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 426,208 | 9,521,000 | 0.54% | ||
| 36 | GOLDMAN SACHS GROUP INC | 413,613 | 9,240,000 | 0.53% | ||
| 37 | Bank of New York Mellon Corp | 388,208 | 8,672,000 | 0.49% | ||
| 38 | D. E. Shaw & Co., Inc. | 369,470 | 8,254,000 | 0.47% | ||
| 39 | Rock Springs Capital Management LP | 360,000 | 8,042,000 | 0.46% | ||
| 40 | AXA S.A. | 342,153 | 7,644,000 | 0.43% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 278,300 | 6,217,000 | 0.35% | Call | |
| 42 | TIAA CREF INVESTMENT MANAGEMENT LLC | 268,377 | 5,996,000 | 0.34% | ||
| 43 | BlackRock Investment Management, LLC | 258,054 | 5,765,000 | 0.33% | ||
| 44 | CREDIT SUISSE AG/ | 253,213 | 5,655,000 | 0.32% | ||
| 45 | FIRST MANHATTAN CO. LLC. | 243,105 | 5,430,000 | 0.31% | ||
| 46 | UBS Group AG | 240,200 | 5,366,000 | 0.31% | Call | |
| 47 | AMUNDI ASSET MANAGEMENT US, INC. | 238,621 | 5,331,000 | 0.30% | ||
| 48 | LORD, ABBETT & CO. LLC | 233,867 | 5,225,000 | 0.30% | ||
| 49 | Asset Management One Co., Ltd. | 221,687 | 4,965,000 | 0.28% | ||
| 50 | BlackRock Group LTD | 220,192 | 4,919,000 | 0.28% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
