| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 11,061,940 | 528,318,000 | 13.07% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 9,793,739 | 467,749,000 | 11.57% | ||
| 3 | VANGUARD GROUP INC | 5,362,428 | 256,109,000 | 6.34% | ||
| 4 | ORBIMED ADVISORS LLC | 5,094,500 | 243,313,000 | 6.02% | ||
| 5 | PERCEPTIVE ADVISORS LLC | 3,284,467 | 156,866,000 | 3.88% | ||
| 6 | BB BIOTECH AG | 3,221,552 | 153,861,000 | 3.81% | ||
| 7 | BlackRock Fund Advisors | 3,175,283 | 151,652,000 | 3.75% | ||
| 8 | PointState Capital LP | 2,285,300 | 109,146,000 | 2.70% | ||
| 9 | Invesco Ltd. | 2,066,074 | 98,675,000 | 2.44% | ||
| 10 | STATE STREET CORP | 2,039,297 | 97,398,000 | 2.41% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 2,024,108 | 96,671,000 | 2.39% | ||
| 12 | Visium Asset Management, LP | 2,007,183 | 95,864,000 | 2.37% | ||
| 13 | JANUS HENDERSON INVESTORS US LLC | 1,742,429 | 83,218,000 | 2.06% | ||
| 14 | Capital World Investors | 1,412,700 | 67,471,000 | 1.67% | ||
| 15 | FRANKLIN RESOURCES INC | 1,354,400 | 64,686,000 | 1.60% | ||
| 16 | EAGLE ASSET MANAGEMENT INC | 1,326,069 | 63,333,000 | 1.57% | ||
| 17 | WESTFIELD CAPITAL MANAGEMENT CO LP | 1,173,440 | 56,043,000 | 1.39% | ||
| 18 | MILLENNIUM MANAGEMENT LLC | 1,156,887 | 55,253,000 | 1.37% | ||
| 19 | DEUTSCHE BANK AG\ | 1,003,927 | 47,946,000 | 1.19% | ||
| 20 | NORTHERN TRUST CORP | 940,760 | 44,931,000 | 1.11% | ||
| 21 | BLACKROCK ADVISORS LLC | 878,635 | 41,964,000 | 1.04% | ||
| 22 | JENNISON ASSOCIATES LLC | 875,731 | 41,825,000 | 1.03% | ||
| 23 | CITADEL ADVISORS LLC | 812,484 | 38,804,000 | 0.96% | ||
| 24 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 796,643 | 38,048,000 | 0.94% | ||
| 25 | ArrowMark Colorado Holdings LLC | 722,849 | 34,523,000 | 0.85% | ||
| 26 | Cormorant Asset Management, LP | 718,900 | 34,335,000 | 0.85% | ||
| 27 | RS INVESTMENT MANAGEMENT CO LLC | 711,010 | 33,958,000 | 0.84% | ||
| 28 | WELLINGTON MANAGEMENT GROUP LLP | 572,498 | 27,342,000 | 0.68% | ||
| 29 | LORD, ABBETT & CO. LLC | 568,182 | 27,136,000 | 0.67% | ||
| 30 | BAKER BROS. ADVISORS LP | 542,236 | 25,897,000 | 0.64% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 528,187 | 25,226,000 | 0.62% | ||
| 32 | Bank of New York Mellon Corp | 472,979 | 22,589,000 | 0.56% | ||
| 33 | NORGES BANK | 467,986 | 22,351,000 | 0.55% | ||
| 34 | EMERALD ADVISERS, LLC | 465,446 | 22,230,000 | 0.55% | ||
| 35 | VOYA INVESTMENT MANAGEMENT LLC | 388,719 | 18,565,000 | 0.46% | ||
| 36 | Rock Springs Capital Management LP | 376,000 | 17,958,000 | 0.44% | ||
| 37 | Tekla Capital Management LLC | 375,860 | 17,951,000 | 0.44% | ||
| 38 | OppenheimerFunds, Inc. | 347,780 | 16,610,000 | 0.41% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 343,400 | 16,401,000 | 0.41% | Call | |
| 40 | BlackRock Investment Management, LLC | 335,516 | 16,024,000 | 0.40% | ||
| 41 | TEACHERS ADVISORS, LLC | 333,440 | 15,925,000 | 0.39% | ||
| 42 | CREDIT SUISSE AG/ | 331,529 | 15,834,000 | 0.39% | ||
| 43 | EMERALD MUTUAL FUND ADVISERS TRUST | 308,678 | 14,742,000 | 0.36% | ||
| 44 | MILLENNIUM MANAGEMENT LLC | 300,000 | 14,328,000 | 0.35% | Call | |
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 291,479 | 13,921,000 | 0.34% | ||
| 46 | AXA S.A. | 289,707 | 13,836,000 | 0.34% | ||
| 47 | LOOMIS SAYLES & CO L P | 288,800 | 13,793,000 | 0.34% | ||
| 48 | FRED ALGER MANAGEMENT, LLC | 286,309 | 13,674,000 | 0.34% | ||
| 49 | JPMORGAN CHASE & CO | 277,796 | 13,268,000 | 0.33% | ||
| 50 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 247,745 | 11,833,000 | 0.29% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
