| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 12,929,143 | 731,401,000 | 15.41% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 9,633,687 | 544,978,000 | 11.48% | ||
| 3 | VANGUARD GROUP INC | 5,938,031 | 335,915,000 | 7.08% | ||
| 4 | BlackRock Fund Advisors | 3,170,412 | 179,350,000 | 3.78% | ||
| 5 | BB BIOTECH AG | 3,121,552 | 176,586,000 | 3.72% | ||
| 6 | ORBIMED ADVISORS LLC | 2,514,974 | 142,272,000 | 3.00% | ||
| 7 | PERCEPTIVE ADVISORS LLC | 2,496,167 | 141,208,000 | 2.97% | ||
| 8 | Visium Asset Management, LP | 2,201,850 | 124,558,000 | 2.62% | ||
| 9 | STATE STREET CORP | 2,182,377 | 123,456,000 | 2.60% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 2,030,765 | 114,880,000 | 2.42% | ||
| 11 | JANUS HENDERSON INVESTORS US LLC | 1,954,908 | 110,589,000 | 2.33% | ||
| 12 | Invesco Ltd. | 1,947,631 | 110,178,000 | 2.32% | ||
| 13 | Capital World Investors | 1,242,500 | 70,288,000 | 1.48% | ||
| 14 | WESTFIELD CAPITAL MANAGEMENT CO LP | 1,221,642 | 69,108,000 | 1.46% | ||
| 15 | FRANKLIN RESOURCES INC | 1,200,300 | 67,901,000 | 1.43% | ||
| 16 | CITADEL ADVISORS LLC | 1,134,824 | 64,197,000 | 1.35% | ||
| 17 | EAGLE ASSET MANAGEMENT INC | 1,103,080 | 62,401,000 | 1.31% | ||
| 18 | BLACKROCK ADVISORS LLC | 1,069,299 | 60,490,000 | 1.27% | ||
| 19 | MILLENNIUM MANAGEMENT LLC | 1,057,623 | 59,830,000 | 1.26% | ||
| 20 | NORTHERN TRUST CORP | 1,037,476 | 58,690,000 | 1.24% | ||
| 21 | DEUTSCHE BANK AG\ | 967,191 | 54,711,000 | 1.15% | ||
| 22 | BAKER BROS. ADVISORS LP | 850,739 | 48,126,000 | 1.01% | ||
| 23 | NORGES BANK | 749,307 | 42,389,000 | 0.89% | ||
| 24 | COLUMBUS CIRCLE INVESTORS | 640,417 | 36,228,000 | 0.76% | ||
| 25 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 611,762 | 34,608,000 | 0.73% | ||
| 26 | RS INVESTMENT MANAGEMENT CO LLC | 609,950 | 34,505,000 | 0.73% | ||
| 27 | Cormorant Asset Management, LP | 603,900 | 34,163,000 | 0.72% | ||
| 28 | LORD, ABBETT & CO. LLC | 584,280 | 33,053,000 | 0.70% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 554,800 | 31,385,000 | 0.66% | ||
| 30 | JPMORGAN CHASE & CO | 553,725 | 31,325,000 | 0.66% | ||
| 31 | VOYA INVESTMENT MANAGEMENT LLC | 535,230 | 30,278,000 | 0.64% | ||
| 32 | PointState Capital LP | 525,000 | 29,699,000 | 0.63% | ||
| 33 | CADIAN CAPITAL MANAGEMENT, LP | 499,872 | 28,278,000 | 0.60% | ||
| 34 | JENNISON ASSOCIATES LLC | 494,607 | 27,980,000 | 0.59% | ||
| 35 | ArrowMark Colorado Holdings LLC | 490,108 | 27,725,000 | 0.58% | ||
| 36 | Bank of New York Mellon Corp | 443,913 | 25,112,000 | 0.53% | ||
| 37 | WELLINGTON MANAGEMENT GROUP LLP | 422,922 | 23,925,000 | 0.50% | ||
| 38 | SECTORAL ASSET MANAGEMENT INC | 416,680 | 23,572,000 | 0.50% | ||
| 39 | ROYAL BANK OF CANADA | 408,272 | 23,096,000 | 0.49% | ||
| 40 | Rock Springs Capital Management LP | 377,500 | 21,355,000 | 0.45% | ||
| 41 | BlackRock Group LTD | 358,755 | 20,295,000 | 0.43% | ||
| 42 | BlackRock Investment Management, LLC | 342,529 | 19,377,000 | 0.41% | ||
| 43 | TEACHERS ADVISORS, LLC | 339,170 | 19,187,000 | 0.40% | ||
| 44 | LOOMIS SAYLES & CO L P | 337,714 | 19,104,000 | 0.40% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 332,166 | 18,791,000 | 0.40% | ||
| 46 | TIAA CREF INVESTMENT MANAGEMENT LLC | 326,356 | 18,462,000 | 0.39% | ||
| 47 | D. E. Shaw & Co., Inc. | 313,467 | 17,733,000 | 0.37% | ||
| 48 | Tekla Capital Management LLC | 311,460 | 17,619,000 | 0.37% | ||
| 49 | EMERALD ADVISERS, LLC | 303,207 | 17,152,000 | 0.36% | ||
| 50 | OppenheimerFunds, Inc. | 300,338 | 16,990,000 | 0.36% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
