| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 11,387,910 | 178,449,000 | 15.13% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 9,983,639 | 156,444,000 | 13.27% | ||
| 3 | ORBIMED ADVISORS LLC | 5,793,600 | 90,786,000 | 7.70% | ||
| 4 | PERCEPTIVE ADVISORS LLC | 4,565,267 | 71,538,000 | 6.07% | ||
| 5 | BB BIOTECH AG | 3,116,552 | 48,836,000 | 4.14% | ||
| 6 | BlackRock Fund Advisors | 2,557,379 | 40,074,000 | 3.40% | ||
| 7 | VANGUARD GROUP INC | 2,283,836 | 35,788,000 | 3.03% | ||
| 8 | STATE STREET CORP | 2,215,134 | 34,714,000 | 2.94% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 2,075,742 | 32,527,000 | 2.76% | ||
| 10 | FRANKLIN RESOURCES INC | 1,838,400 | 28,808,000 | 2.44% | ||
| 11 | Visium Asset Management, LP | 1,787,261 | 28,007,000 | 2.37% | ||
| 12 | ArrowMark Colorado Holdings LLC | 1,544,579 | 24,204,000 | 2.05% | ||
| 13 | Tekla Capital Management LLC | 1,281,950 | 20,088,000 | 1.70% | ||
| 14 | GREAT POINT PARTNERS LLC | 1,161,739 | 18,204,000 | 1.54% | ||
| 15 | Capital World Investors | 1,150,200 | 18,024,000 | 1.53% | ||
| 16 | LOOMIS SAYLES & CO L P | 1,034,359 | 16,208,000 | 1.37% | ||
| 17 | JANUS HENDERSON INVESTORS US LLC | 999,155 | 15,657,000 | 1.33% | ||
| 18 | DEUTSCHE BANK AG\ | 953,370 | 14,938,000 | 1.27% | ||
| 19 | BLACKROCK ADVISORS LLC | 945,411 | 14,815,000 | 1.26% | ||
| 20 | CITADEL ADVISORS LLC | 935,308 | 14,656,000 | 1.24% | ||
| 21 | NORTHERN TRUST CORP | 930,925 | 14,587,000 | 1.24% | ||
| 22 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 929,398 | 14,564,000 | 1.23% | ||
| 23 | WELLINGTON MANAGEMENT GROUP LLP | 865,603 | 13,564,000 | 1.15% | ||
| 24 | Cormorant Asset Management, LP | 850,000 | 13,320,000 | 1.13% | ||
| 25 | THRIVENT FINANCIAL FOR LUTHERANS | 656,063 | 10,280,000 | 0.87% | ||
| 26 | PERCEPTIVE ADVISORS LLC | 653,000 | 10,233,000 | 0.87% | Put | |
| 27 | GOLDMAN SACHS GROUP INC | 617,432 | 9,675,000 | 0.82% | ||
| 28 | FRED ALGER MANAGEMENT, LLC | 595,830 | 9,337,000 | 0.79% | ||
| 29 | BAKER BROS. ADVISORS LP | 554,590 | 8,690,000 | 0.74% | ||
| 30 | AMUNDI ASSET MANAGEMENT US, INC. | 503,938 | 7,897,000 | 0.67% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 415,673 | 6,513,000 | 0.55% | ||
| 32 | Bank of New York Mellon Corp | 389,488 | 6,103,000 | 0.52% | ||
| 33 | GOLDMAN SACHS GROUP INC | 379,500 | 5,947,000 | 0.50% | Call | |
| 34 | AXA S.A. | 359,835 | 5,639,000 | 0.48% | ||
| 35 | MILLENNIUM MANAGEMENT LLC | 341,926 | 5,358,000 | 0.45% | ||
| 36 | EMERALD ADVISERS, LLC | 334,183 | 5,237,000 | 0.44% | ||
| 37 | LORD, ABBETT & CO. LLC | 321,788 | 5,042,000 | 0.43% | ||
| 38 | Rock Springs Capital Management LP | 315,000 | 4,936,000 | 0.42% | ||
| 39 | EMERALD MUTUAL FUND ADVISERS TRUST | 303,909 | 4,762,000 | 0.40% | ||
| 40 | VHCP Management, LLC | 303,503 | 4,756,000 | 0.40% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 301,411 | 4,723,000 | 0.40% | ||
| 42 | D. E. Shaw & Co., Inc. | 295,902 | 4,636,000 | 0.39% | ||
| 43 | Tekla Capital Management LLC | 281,600 | 4,413,000 | 0.37% | Call | |
| 44 | BlackRock Investment Management, LLC | 262,580 | 4,115,000 | 0.35% | ||
| 45 | Allianz Asset Management GmbH | 255,210 | 4,000,000 | 0.34% | ||
| 46 | FIRST MANHATTAN CO. LLC. | 243,105 | 3,809,000 | 0.32% | ||
| 47 | BlackRock Group LTD | 241,578 | 3,785,000 | 0.32% | ||
| 48 | CREDIT SUISSE AG/ | 227,929 | 3,573,000 | 0.30% | ||
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 213,400 | 3,344,000 | 0.28% | Put | |
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 207,100 | 3,245,000 | 0.28% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
