| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 11,890,154 | 472,158,000 | 13.82% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 9,877,839 | 392,249,000 | 11.48% | ||
| 3 | ORBIMED ADVISORS LLC | 5,833,600 | 231,652,000 | 6.78% | ||
| 4 | VANGUARD GROUP INC | 3,942,855 | 156,571,000 | 4.58% | ||
| 5 | PERCEPTIVE ADVISORS LLC | 3,741,267 | 148,566,000 | 4.35% | ||
| 6 | BlackRock Fund Advisors | 3,250,342 | 129,071,000 | 3.78% | ||
| 7 | BB BIOTECH AG | 3,201,552 | 127,134,000 | 3.72% | ||
| 8 | Visium Asset Management, LP | 3,019,877 | 119,919,000 | 3.51% | ||
| 9 | PointState Capital LP | 2,633,400 | 104,572,000 | 3.06% | ||
| 10 | WESTFIELD CAPITAL MANAGEMENT CO LP | 2,288,350 | 90,870,000 | 2.66% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 2,139,496 | 84,959,000 | 2.49% | ||
| 12 | STATE STREET CORP | 1,996,739 | 79,292,000 | 2.32% | ||
| 13 | Invesco Ltd. | 1,837,826 | 72,980,000 | 2.14% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 1,472,873 | 58,488,000 | 1.71% | ||
| 15 | Capital World Investors | 1,465,200 | 58,183,000 | 1.70% | ||
| 16 | FRANKLIN RESOURCES INC | 1,354,400 | 53,783,000 | 1.57% | ||
| 17 | JANUS HENDERSON INVESTORS US LLC | 1,344,601 | 53,394,000 | 1.56% | ||
| 18 | EAGLE ASSET MANAGEMENT INC | 1,298,434 | 51,560,000 | 1.51% | ||
| 19 | DEUTSCHE BANK AG\ | 1,053,574 | 41,835,000 | 1.22% | ||
| 20 | NORTHERN TRUST CORP | 990,964 | 39,351,000 | 1.15% | ||
| 21 | LORD, ABBETT & CO. LLC | 987,584 | 39,217,000 | 1.15% | ||
| 22 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 889,998 | 35,342,000 | 1.03% | ||
| 23 | JENNISON ASSOCIATES LLC | 869,668 | 34,535,000 | 1.01% | ||
| 24 | BLACKROCK ADVISORS LLC | 792,354 | 31,464,000 | 0.92% | ||
| 25 | ArrowMark Colorado Holdings LLC | 761,330 | 30,232,000 | 0.88% | ||
| 26 | Cormorant Asset Management, LP | 718,900 | 28,548,000 | 0.84% | ||
| 27 | RS INVESTMENT MANAGEMENT CO LLC | 596,880 | 23,702,000 | 0.69% | ||
| 28 | WELLINGTON MANAGEMENT GROUP LLP | 587,168 | 23,317,000 | 0.68% | ||
| 29 | GOLDMAN SACHS GROUP INC | 568,608 | 22,579,000 | 0.66% | ||
| 30 | BAKER BROS. ADVISORS LP | 542,236 | 21,532,000 | 0.63% | ||
| 31 | Tekla Capital Management LLC | 501,150 | 19,901,000 | 0.58% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 494,234 | 19,626,000 | 0.57% | ||
| 33 | BANK OF MONTREAL /CAN/ | 447,200 | 17,758,000 | 0.52% | ||
| 34 | EMERALD ADVISERS, LLC | 462,253 | 17,464,000 | 0.51% | ||
| 35 | Bank of New York Mellon Corp | 436,911 | 17,349,000 | 0.51% | ||
| 36 | Alberta Investment Management Corp | 399,877 | 15,879,000 | 0.46% | ||
| 37 | CITADEL ADVISORS LLC | 392,550 | 15,588,000 | 0.46% | ||
| 38 | FRED ALGER MANAGEMENT, LLC | 389,770 | 15,478,000 | 0.45% | ||
| 39 | Rock Springs Capital Management LP | 375,000 | 14,891,000 | 0.44% | ||
| 40 | EMERALD MUTUAL FUND ADVISERS TRUST | 347,627 | 13,133,000 | 0.38% | ||
| 41 | TEACHERS ADVISORS, LLC | 320,701 | 12,735,000 | 0.37% | ||
| 42 | D. E. Shaw & Co., Inc. | 297,292 | 11,805,000 | 0.35% | ||
| 43 | AXA S.A. | 289,707 | 11,504,000 | 0.34% | ||
| 44 | CREDIT SUISSE AG/ | 287,779 | 11,426,000 | 0.33% | ||
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 285,900 | 11,353,000 | 0.33% | ||
| 46 | BlackRock Investment Management, LLC | 274,916 | 10,917,000 | 0.32% | ||
| 47 | Allianz Asset Management GmbH | 267,539 | 10,624,000 | 0.31% | ||
| 48 | LOOMIS SAYLES & CO L P | 249,963 | 9,926,000 | 0.29% | ||
| 49 | TD ASSET MANAGEMENT INC | 243,100 | 9,654,000 | 0.28% | ||
| 50 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 240,237 | 9,540,000 | 0.28% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
